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Protein

S-adenosylmethionine mitochondrial carrier protein

Gene

SLC25A26

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Specifically mediates the transport of S-adenosylmethionine (SAM) into the mitochondria (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
S-adenosylmethionine mitochondrial carrier protein
Alternative name(s):
Mitochondrial S-adenosylmethionine transporter
Solute carrier family 25 member 26
Gene namesi
Name:SLC25A26
Synonyms:SAMC
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 25Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei49 – 69Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei85 – 105Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei182 – 202Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003175861 – 274S-adenosylmethionine mitochondrial carrier proteinAdd BLAST274

Proteomic databases

PaxDbiA6QR09
PRIDEiA6QR09

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000050467

Structurei

3D structure databases

ProteinModelPortaliA6QR09
SMRiA6QR09
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati4 – 77Solcar 1Add BLAST74
Repeati86 – 168Solcar 2Add BLAST83
Repeati177 – 265Solcar 3Add BLAST89

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0768 Eukaryota
ENOG4110BII LUCA
HOGENOMiHOG000038810
HOVERGENiHBG108456
InParanoidiA6QR09
KOiK15111

Family and domain databases

Gene3Di1.50.40.10, 2 hits
InterProiView protein in InterPro
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 4 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

A6QR09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRPGFTASL VAGGVAGVSV DLILFPLDTI KTRLQSPQGF YKAGGFYGVY
60 70 80 90 100
AGVPSTAIGS FPNAAAFFVT YEYVKWILHT DSSSYLMPVT HMLAASVGEV
110 120 130 140 150
VACLIRVPSE VVKQRAQVSA SSGTFHIFSN ILCQEGIQGL YRGYKSTVLR
160 170 180 190 200
EIPFSLVQFP LWESLKALWS WRQDRVVDSW QAAVCGAFAG GFAAAVTTPL
210 220 230 240 250
DVAKTRIMLA KAGSSTASGN ILSALHAVWR TQGLSGLFAG VFPRMAAISL
260 270
GGFIFLGVYD QTRSFLLELG RESP
Length:274
Mass (Da):29,409
Last modified:August 21, 2007 - v1
Checksum:iD0B86C6672135784
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC150067 mRNA Translation: AAI50068.1
RefSeqiNP_001096767.1, NM_001103297.1
UniGeneiBt.88477

Genome annotation databases

GeneIDi614713
KEGGibta:614713

Similar proteinsi

Entry informationi

Entry nameiSAMC_BOVIN
AccessioniPrimary (citable) accession number: A6QR09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 21, 2007
Last modified: February 28, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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