Protein arginine N-methyltransferase 7

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A6QQV6 (ANM7_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 35. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Protein arginine N-methyltransferase 7
EC=2.1.1.-

Alternative name(s):
Histone-arginine N-methyltransferase PRMT7
EC=2.1.1.125
[Myelin basic protein]-arginine N-methyltransferase PRMT7
EC=2.1.1.126

Gene names

Name:

PRMT7

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	695 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo By similarity.
Catalytic activity	S-adenosyl-L-methionine + arginine-[histone] = S-adenosyl-L-homocysteine + N(omega)-methyl-arginine-[histone]. S-adenosyl-L-methionine + [myelin basic protein]-arginine = S-adenosyl-L-homocysteine + [myelin basic protein]-N(omega)-methyl-arginine.
Subunit structure	Homodimer and heterodimer. Interacts with CTCFL, PRMT5 and SNRPD3 By similarity.
Subcellular location	Cytoplasm › cytosol By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the protein arginine N-methyltransferase family. PRMT7 subfamily.

Ontologies

Keywords
Biological process	Differentiation Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Ligand	S-adenosyl-L-methionine
Molecular function	Chromatin regulator Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	DNA methylation involved in gamete generation Inferred from sequence or structural similarity. Source: UniProtKB cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW regulation of gene expression by genetic imprinting Inferred from sequence or structural similarity. Source: UniProtKB regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW spliceosomal snRNP assembly Inferred from sequence or structural similarity. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytosol Inferred from sequence or structural similarity. Source: UniProtKB nucleus Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	[myelin basic protein]-arginine N-methyltransferase activity Inferred from electronic annotation. Source: EC histone methyltransferase activity (H4-R3 specific) Inferred from sequence or structural similarity. Source: UniProtKB protein-arginine omega-N symmetric methyltransferase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 695

695

Protein arginine N-methyltransferase 7

PRO_0000373901

Sequences

Sequence

Length

Mass (Da)

Tools

A6QQV6 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: D668901147C94E95
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FASTA

695

78,654

        10         20         30         40         50         60 
MKVFCGRANP TTGSVEWLEE DEHYDYHQEI ARSSYADMLH DKDRNMKYYQ GIRAAVSRVK 

        70         80         90        100        110        120 
DRGQKALVLD IGTGTGLLSM MAVTAGADFC YAIEVFKPMA DAAVKIVEKN GFSDKIKVIN 

       130        140        150        160        170        180 
KHSTEVTVGP DGDMPCRANI LITELFDTEL IGEGALPSYE HAHRHLVQAN CEAVPHRATV 

       190        200        210        220        230        240 
YAQLVESRRM WSWNKLFPIR VQTSRGERVI IPPLELERCP GAPSVCDIQL NQVSPADFTI 

       250        260        270        280        290        300 
LSDVLPMFSV DFSKQVSSSA ACHSRQFEPL VSGRAQVVLS WWDIEMDPEG KIKCTMAPSW 

       310        320        330        340        350        360 
AHSDPEELQW RDHWMQCVYF LPQEEPVVQG LALCLVAYHD DYCVWYSLQK TSPEKNGRVH 

       370        380        390        400        410        420 
PVRPVCDCQA HLLWNRPRFG EINDRNRTDQ YIQALRTVLK PDSVCLCVSD GSLLSMLAYH 

       430        440        450        460        470        480 
LGVEQVFTIE NSAVSHRLMK KIFKANHLED KINIIEKRPE LLTPADLEGK KVSLLLGEPF 

       490        500        510        520        530        540 
FTTSLLPWHN LYFWYVRTAV DQHLGPGAVV MPQAASLHVV VVEFRDLWRI RSPCGDCEGF 

       550        560        570        580        590        600 
DVHIMDDMIK RALDFRESKE AEPHPLWEYP CSSLSEPQQI LTFDFRQPVP LQPIHAEGTI 

       610        620        630        640        650        660 
ELRRCGRSHG AVLWMEYHLT ADSTVSTGLL KSAEDEGDCC WNPHCKQAVY FFNTTLDPRA 

       670        680        690 
PPGSSQTVTY TVEFHPHTGD ITMDFTLSDA LDSGC

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References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Thymus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC150009 mRNA. Translation: AAI50010.1.
IPI	IPI00867369.
RefSeq	NP_001095460.1. NM_001101990.1.
UniGene	Bt.21927.
3D structure databases
ProteinModelPortal	A6QQV6.
ModBase	Search...
Protein-protein interaction databases
STRING	A6QQV6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	514202.
KEGG	bta:514202.
Organism-specific databases
CTD	54496.
Phylogenomic databases
eggNOG	maNOG09829.
GeneTree	ENSGT00530000063495.
InParanoid	A6QQV6.
OrthoDB	EOG48KR9T.
Family and domain databases
InterPro	IPR014644. Arg_N-MeTrfase. IPR010456. Ribosomal-L11_MeTrfase_PrmA. [Graphical view]
KO	K11438.
Pfam	PF06325. PrmA. 1 hit. [Graphical view]
PIRSF	PIRSF036946. Arg_N-mtase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ANM7_BOVIN

Accession

Primary (citable) accession number: A6QQV6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 5, 2009
Last sequence update:	August 21, 2007
Last modified:	November 16, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents