Reviewed, UniProtKB/Swiss-Prot A6QQT9 (ILVBL_BOVIN)

Names and origin

Protein names

Recommended name:
    Acetolactate synthase-like protein
    EC=2.2.1.-
Alternative name(s):
    IlvB-like protein

Gene names

Name:

ILVBL

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	632 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Cofactor	Binds 1 magnesium ion per subunit By similarity. Binds 1 thiamine pyrophosphate per subunit By similarity.
Subcellular location	Membrane; Single-pass membrane protein.
Sequence similarities	Belongs to the TPP enzyme family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane
Ligand	Magnesium Metal-binding Thiamine pyrophosphate
Molecular function	Transferase
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW thiamin pyrophosphate binding Inferred from electronic annotation. Source: InterPro transferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 632	632	Acetolactate synthase-like protein		PRO_0000314824
Regions
	Transmembrane	10 – 30	21	Potential
	Region	470 – 550	81	Thiamine pyrophosphate binding By similarity
Sites
	Metal binding	521	1	Magnesium By similarity
	Metal binding	547	1	Magnesium By similarity
	Binding site	98	1	Thiamine pyrophosphate By similarity
Experimental info
	Sequence conflict	10	1	A → V in AAX08821. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	A6QQT9-1 [UniParc]. Last modified January 15, 2008. Version 2. Checksum: 13BC87555BF24616	FASTA	632	68,110
	10 20 30 40 50 60 METAVAAAPA WGFFSSFLLL AFGTLVAALL GAAHRLGLFY QLMHKVDTAS TRHGGENVAA 70 80 90 100 110 120 VLKAHGVRFL FTLVGGHISP LLVACEKLGI RVVDTRHEVT AVFAADAVAR LTGTVGVAAV 130 140 150 160 170 180 TAGPGLTNTV TAVKNAQIAQ SPVLLLGGAA STLLQNRGAL QAIDQIALFR PLCKFCASVR 190 200 210 220 230 240 RVRDIIPTLR AAMAAAQSGT PGPVFVELPL DVLYPYFMVQ KEMVPAKPPK GLMSRAVHWY 250 260 270 280 290 300 LANSLANLFA GAWEPQPEGP LPLDIPQASP QQVQRCVEIL SRAKKPLMLI GSQALLPPTS 310 320 330 340 350 360 SDKLRVAVET LGIPCFLAGM ARGLLGRNHP LHFRQNRRAA LKKADVVVLA GAVCDFRLSY 370 380 390 400 410 420 GRVLSRSSKI IVVNRDRKEM LINSDIFWKP QEAVQGDVGS FVVKLVEGLR GQMWASDWAE 430 440 450 460 470 480 ELRQADQQKE QAFREKALMP VAQHLNPVRV LQLVEDTLPD NSILVVDGGD FVGTAAYLVQ 490 500 510 520 530 540 PRGPLRWLDP GAFGTLGVGA GFALGAKLCR PDAEVWCLFG DGAFGYSLIE FDTFVRHKIP 550 560 570 580 590 600 VMALIGNDAG WTQISREQVP SLGSNVACGL AYTDYHKAAQ GLGAQGLLLS RENEDQVVKV 610 620 630 LRDAQQWCQD GHPVVVNILI GRTDFRDGSI AM

References

[1]	"Characterization of 954 bovine full-CDS cDNA sequences." Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L. BMC Genomics 6:166-166(2005) [PubMed: 16305752] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Hypothalamus.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BT020804 mRNA. Translation: AAX08821.1. Different initiation. BC149989 mRNA. Translation: AAI49990.1. Different initiation.
IPI	IPI00712673.
RefSeq	NP_001015535.1.
UniGene	Bt.24640
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000015186. Bos taurus. [Contig view]
GeneID	506955.
KEGG	bta:506955.
Family and domain databases
InterPro	IPR000399. TPP_bd_CS. IPR012001. TPP_bd_enzyme_N. IPR011766. TPP_enzyme_bd_C. IPR012000. TPP_enzyme_M. [Graphical view]
Pfam	PF02775. TPP_enzyme_C. 1 hit. PF00205. TPP_enzyme_M. 1 hit. PF02776. TPP_enzyme_N. 1 hit. [Graphical view]
PROSITE	PS00187. TPP_ENZYMES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ILVBL_BOVIN

Accession

Primary (citable) accession number: A6QQT9
Secondary accession number(s): Q5E9W6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 15, 2008
Last modified:	June 16, 2009
This is version 14 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)