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Protein

DNA excision repair protein ERCC-6-like

Gene

ERCC6L

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi122 – 129ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Helicase, Hydrolase
Biological processCell cycle, Cell division, Mitosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-BTA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-BTA-2467813 Separation of Sister Chromatids
R-BTA-2500257 Resolution of Sister Chromatid Cohesion
R-BTA-5663220 RHO GTPases Activate Formins
R-BTA-68877 Mitotic Prometaphase

Names & Taxonomyi

Protein namesi
Recommended name:
DNA excision repair protein ERCC-6-like (EC:3.6.4.12By similarity)
Alternative name(s):
ATP-dependent helicase ERCC6-like
Gene namesi
Name:ERCC6L
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome X

Organism-specific databases

VGNCiVGNC:28573 ERCC6L

Subcellular locationi

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003288301 – 1242DNA excision repair protein ERCC-6-likeAdd BLAST1242

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineBy similarity1
Modified residuei755PhosphoserineBy similarity1
Modified residuei773PhosphoserineBy similarity1
Modified residuei815PhosphothreonineBy similarity1
Modified residuei963PhosphoserineBy similarity1
Modified residuei989PhosphoserineBy similarity1
Modified residuei998PhosphoserineBy similarity1
Modified residuei1021PhosphoserineBy similarity1
Modified residuei1055PhosphothreonineBy similarity1
Modified residuei1061PhosphoserineBy similarity1
Modified residuei1090PhosphoserineBy similarity1
Modified residuei1110PhosphoserineBy similarity1
Modified residuei1173PhosphoserineBy similarity1
Modified residuei1180PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation by PLK1 prevents the association with chromosome arms and restricts its localization to the kinetochore-centromere region.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA6QQR4
PRIDEiA6QQR4

Expressioni

Gene expression databases

BgeeiENSBTAG00000005607

Interactioni

Subunit structurei

Interacts with PLK1, which phosphorylates it. Both proteins are mutually dependent on each other for correct subcellular localization. Interacts (via N-terminal TPR repeat) with BEND3 (via BEN domains 1 and 3); the interaction is direct.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007362

Structurei

3D structure databases

ProteinModelPortaliA6QQR4
SMRiA6QQR4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati21 – 54TPR 1Add BLAST34
Domaini109 – 277Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST169
Domaini466 – 626Helicase C-terminalPROSITE-ProRule annotationAdd BLAST161
Repeati1192 – 1225TPR 2Add BLAST34

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi228 – 231DEAH box4

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0387 Eukaryota
ENOG410XP4Z LUCA
GeneTreeiENSGT00590000083118
HOGENOMiHOG000074172
HOVERGENiHBG107854
InParanoidiA6QQR4
KOiK20093
OMAiICEMPSL
OrthoDBiEOG091G058Q
TreeFamiTF332843

Family and domain databases

CDDicd00079 HELICc, 1 hit
Gene3Di3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
PfamiView protein in Pfam
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 3 hits
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

Sequencei

Sequence statusi: Complete.

A6QQR4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVSRGFAEA GALSPEQAAS YLRYVKEAKE ATKNGDLEQA LKLFNLAKDI
60 70 80 90 100
FPNEKVMSRI QKIQEALEEL AEHGDDEFID VCNSGLLLYQ ELHNQLYEYQ
110 120 130 140 150
KEGIAFLYSL YRDGRRGGIL ADDMGLGKTV QIIAFLSGMF DASLVNHVLL
160 170 180 190 200
IMPTSLISTW LREFVKWTPG MRVKTFHGPS KDERTRNLCR IQQRNGVIIT
210 220 230 240 250
TYQMLINNWQ QLSSLNGQEF LWDYVILDEA HKIKSSSTKS AICARAIPAS
260 270 280 290 300
NRILLTGTPI QNNLQELWSL FDFACQGSLL GTLRTFKMEY ENPITRAREK
310 320 330 340 350
DATPGEKALG FKISENLMAI IKPYFLRRTK EEVQKKKSSN PEVQLSEKSP
360 370 380 390 400
DVGAICEMPS LSRKNDLIIW IRLVPLQEEI YRKFVSLDHI KELLMETRSP
410 420 430 440 450
LAELGVLKKL CDHPRLLSAR ACGLLNLGAA KFSVQDEIEG EDSSDVDHID
460 470 480 490 500
QISDDTLMEE SGKMLFLMDL LKKLRDEGHQ TLVFSQSRRI LNIIERLLKN
510 520 530 540 550
RHFKILRIDG TITHLVEREK RISLFQQNKD YSVFLLTTQV GGVGLTLTAA
560 570 580 590 600
SRVVIFDPSW NPATDAQAVD RVYRIGQKEN VVVYRLITCG TVEEKIYRRQ
610 620 630 640 650
VFKDSLIRQT TGDKKNPFRY FSKQELRELF TIEDFQNSAT QLQLQSLHAA
660 670 680 690 700
QRRSDKNLDE HIAFLHSLRI AGISDHDLMY TRDLSVKEEL DVIEDSHYIQ
710 720 730 740 750
QRVQKAQFLV ESESQNTELL MERQKMGNEG IWLREPVYQT KKKRPKVNKP
760 770 780 790 800
QPQPSSHLPV YHTQEEISSL MASIIIDDLP KEDEKDLSRI KLNDTIPQDG
810 820 830 840 850
RHPCVITLND DFVTTLPKGC GDVEEIFPDS LSGMALQKEA SQEGFMQESE
860 870 880 890 900
QESPLASFNY LPSKSARVDL GPNLDQLEDD EVLHHCNPSP ANPKTKEYQR
910 920 930 940 950
PESNVSVIKI ADDDLTAAHS ALQDAQANEA KLEEEPLASS GQYACDFNLF
960 970 980 990 1000
LEDSADNGQN LSSQFLEHVE KENSLCGSAA NSRAESVHSK ACLSVDLSEE
1010 1020 1030 1040 1050
DDEPEEVVNV KIRRKARRID SDNEDEHTFK DTSSTNPFNT SPFPFLSVKQ
1060 1070 1080 1090 1100
FDASTPKNDI SLPERFFSPK ISDSINKSVN SRRSLASRRS LINVVLDHVE
1110 1120 1130 1140 1150
DMEERLDNSS EAKVVEDHLE EGAEESGDEA PEHTKEDPSR ETLSSENKSS
1160 1170 1180 1190 1200
QLSTSKPGAL AQETSPGDPE PLSDGQLVDS PQDEAMEAVN DYDTLVLHGK
1210 1220 1230 1240
ELKECGKIQE ALDCLVKALD IKSSDPEVML MTLSLYKQLN KT
Length:1,242
Mass (Da):140,510
Last modified:August 21, 2007 - v1
Checksum:iFF6F937D56CA8C6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC149963 mRNA Translation: AAI49964.1
BT026201 mRNA Translation: ABG67040.1
RefSeqiNP_001096000.1, NM_001102530.2
UniGeneiBt.74729

Genome annotation databases

EnsembliENSBTAT00000007362; ENSBTAP00000007362; ENSBTAG00000005607
GeneIDi782916
KEGGibta:782916

Similar proteinsi

Entry informationi

Entry nameiERC6L_BOVIN
AccessioniPrimary (citable) accession number: A6QQR4
Secondary accession number(s): Q0V8L7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: August 21, 2007
Last modified: April 25, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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