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Protein

Ribonuclease ZC3H12A

Gene

ZC3H12A

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Has RNase activity and selectively degrades specific target mRNA species. Modulates the immune response and inflammation by regulating the decay of specific mRNA molecules. Recognizes the 3'-untranslated region (UTR) of the mRNA for IL6, CALCR and IL12B. Required for normal decay of IL6 mRNA. Triggers apoptosis and promotes angiogenesis in response to the binding of CCL2 to CCR2. Regulates expression of CDH12 and CHD19 (By similarity).By similarity

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi210 – 2101MagnesiumBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri284 – 30926C3H1-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

Angiogenesis, Apoptosis, Differentiation

Keywords - Ligandi

Magnesium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease ZC3H12A (EC:3.1.-.-)
Alternative name(s):
Zinc finger CCCH domain-containing protein 12A
Gene namesi
Name:ZC3H12ABy similarity
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 583583Ribonuclease ZC3H12APRO_0000341511Add
BLAST

Proteomic databases

PaxDbiA6QQJ8.
PRIDEiA6QQJ8.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015041.

Structurei

3D structure databases

ProteinModelPortaliA6QQJ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni96 – 297202RNaseBy similarityAdd
BLAST
Regioni198 – 2047RNA bindingBy similarity

Sequence similaritiesi

Belongs to the ZC3H12 family.Curated
Contains 1 C3H1-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri284 – 30926C3H1-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3777. Eukaryota.
ENOG410ZNK1. LUCA.
GeneTreeiENSGT00750000117218.
HOGENOMiHOG000060218.
HOVERGENiHBG108758.
InParanoidiA6QQJ8.
KOiK18668.
OMAiFPPREYW.
OrthoDBiEOG7NSB2F.
TreeFamiTF315783.

Family and domain databases

InterProiIPR021869. RNase_Zc3h12_NYN.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF11977. RNase_Zc3h12a. 1 hit.
[Graphical view]
PROSITEiPS50103. ZF_C3H1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6QQJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLWELEDRR SCQGTPRPAQ EPTAEEATTA ELQMKVDFFR KLGYSSAEIH
60 70 80 90 100
SVLQKLGIQA DTNTVLGELV KHGSAAERER QASPDPCPQL PLVPRGGGTP
110 120 130 140 150
KAPTVETYPP EEDKEGSDLR PIVIDGSNVA MSHGNKDVFS CRGILLAVNW
160 170 180 190 200
FLERGHTDIT VFVPSWRKEQ PRPDVPITDQ HILRDLEKKK ILVFTPSRRV
210 220 230 240 250
GGKRVVCYDD RFIVKLAFES DGIVVSNDTY RDLQGERQEW KRFIEERLLM
260 270 280 290 300
YSFVNDKFMP PDDPLGRHGP SLDNFLRKKP LTSEHKKQPC PYGRKCTYGI
310 320 330 340 350
KCRFLHPERP SRPQRSVADE LRANALLPPS RAASKDKNSR RPSPSSQPGS
360 370 380 390 400
LPTEHEQCSP DRKKLGAQAS PGTPREGLMQ TFAPTGRSLP PSGSSGGSFG
410 420 430 440 450
PSEWFPQTLD SLPYASQDCL DSGIGSLESQ MSELWGVRGG GPGEPGPPRG
460 470 480 490 500
PYAGYCTYGA ELPATPAFSA FSRALGAGHF SVPADYAPPP AAFPPREYWS
510 520 530 540 550
EPYQLPPPTQ RLQEPQAPGP GADRGPWGGA GRLAKERASV YTKLCGVFPP
560 570 580
HLVEAVMSRF PQLLDPQQLA AEILSYKSQH LSE
Length:583
Mass (Da):64,263
Last modified:August 21, 2007 - v1
Checksum:iA9258510092CD5D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC149867 mRNA. Translation: AAI49868.1.
RefSeqiNP_001095657.1. NM_001102187.1.
XP_005204850.1. XM_005204793.3.
UniGeneiBt.8745.

Genome annotation databases

EnsembliENSBTAT00000015041; ENSBTAP00000015041; ENSBTAG00000011316.
GeneIDi535344.
KEGGibta:535344.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC149867 mRNA. Translation: AAI49868.1.
RefSeqiNP_001095657.1. NM_001102187.1.
XP_005204850.1. XM_005204793.3.
UniGeneiBt.8745.

3D structure databases

ProteinModelPortaliA6QQJ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015041.

Proteomic databases

PaxDbiA6QQJ8.
PRIDEiA6QQJ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000015041; ENSBTAP00000015041; ENSBTAG00000011316.
GeneIDi535344.
KEGGibta:535344.

Organism-specific databases

CTDi80149.

Phylogenomic databases

eggNOGiKOG3777. Eukaryota.
ENOG410ZNK1. LUCA.
GeneTreeiENSGT00750000117218.
HOGENOMiHOG000060218.
HOVERGENiHBG108758.
InParanoidiA6QQJ8.
KOiK18668.
OMAiFPPREYW.
OrthoDBiEOG7NSB2F.
TreeFamiTF315783.

Family and domain databases

InterProiIPR021869. RNase_Zc3h12_NYN.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF11977. RNase_Zc3h12a. 1 hit.
[Graphical view]
PROSITEiPS50103. ZF_C3H1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: HerefordImported.
    Tissue: HippocampusImported.

Entry informationi

Entry nameiZC12A_BOVIN
AccessioniPrimary (citable) accession number: A6QQJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: August 21, 2007
Last modified: June 8, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.