Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ribonuclease ZC3H12A

Gene

ZC3H12A

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Has RNase activity and selectively degrades specific target mRNA species. Modulates the immune response and inflammation by regulating the decay of specific mRNA molecules. Recognizes the 3'-untranslated region (UTR) of the mRNA for IL6, CALCR and IL12B. Required for normal decay of IL6 mRNA. Triggers apoptosis and promotes angiogenesis in response to the binding of CCL2 to CCR2. Regulates expression of CDH12 and CHD19 (By similarity).By similarity

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi210MagnesiumBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri284 – 309C3H1-typePROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Endonuclease, Hydrolase, Nuclease
Biological processAngiogenesis, Apoptosis, Differentiation
LigandMagnesium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease ZC3H12A (EC:3.1.-.-)
Alternative name(s):
Zinc finger CCCH domain-containing protein 12A
Gene namesi
Name:ZC3H12ABy similarity
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Organism-specific databases

VGNCiVGNC:37097 ZC3H12A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003415111 – 583Ribonuclease ZC3H12AAdd BLAST583

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei83PhosphoserineBy similarity1
Modified residuei422PhosphoserineBy similarity1
Modified residuei426PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA6QQJ8
PRIDEiA6QQJ8

Expressioni

Gene expression databases

BgeeiENSBTAG00000011316

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015041

Structurei

3D structure databases

ProteinModelPortaliA6QQJ8
SMRiA6QQJ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni96 – 297RNaseBy similarityAdd BLAST202
Regioni198 – 204RNA bindingBy similarity7

Sequence similaritiesi

Belongs to the ZC3H12 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri284 – 309C3H1-typePROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3777 Eukaryota
ENOG410ZNK1 LUCA
GeneTreeiENSGT00750000117218
HOGENOMiHOG000060218
HOVERGENiHBG108758
InParanoidiA6QQJ8
KOiK18668
OMAiFPPREYW
OrthoDBiEOG091G03B2
TreeFamiTF315783

Family and domain databases

InterProiView protein in InterPro
IPR021869 RNase_Zc3h12_NYN
IPR000571 Znf_CCCH
PfamiView protein in Pfam
PF11977 RNase_Zc3h12a, 1 hit
PROSITEiView protein in PROSITE
PS50103 ZF_C3H1, 1 hit

Sequencei

Sequence statusi: Complete.

A6QQJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLWELEDRR SCQGTPRPAQ EPTAEEATTA ELQMKVDFFR KLGYSSAEIH
60 70 80 90 100
SVLQKLGIQA DTNTVLGELV KHGSAAERER QASPDPCPQL PLVPRGGGTP
110 120 130 140 150
KAPTVETYPP EEDKEGSDLR PIVIDGSNVA MSHGNKDVFS CRGILLAVNW
160 170 180 190 200
FLERGHTDIT VFVPSWRKEQ PRPDVPITDQ HILRDLEKKK ILVFTPSRRV
210 220 230 240 250
GGKRVVCYDD RFIVKLAFES DGIVVSNDTY RDLQGERQEW KRFIEERLLM
260 270 280 290 300
YSFVNDKFMP PDDPLGRHGP SLDNFLRKKP LTSEHKKQPC PYGRKCTYGI
310 320 330 340 350
KCRFLHPERP SRPQRSVADE LRANALLPPS RAASKDKNSR RPSPSSQPGS
360 370 380 390 400
LPTEHEQCSP DRKKLGAQAS PGTPREGLMQ TFAPTGRSLP PSGSSGGSFG
410 420 430 440 450
PSEWFPQTLD SLPYASQDCL DSGIGSLESQ MSELWGVRGG GPGEPGPPRG
460 470 480 490 500
PYAGYCTYGA ELPATPAFSA FSRALGAGHF SVPADYAPPP AAFPPREYWS
510 520 530 540 550
EPYQLPPPTQ RLQEPQAPGP GADRGPWGGA GRLAKERASV YTKLCGVFPP
560 570 580
HLVEAVMSRF PQLLDPQQLA AEILSYKSQH LSE
Length:583
Mass (Da):64,263
Last modified:August 21, 2007 - v1
Checksum:iA9258510092CD5D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC149867 mRNA Translation: AAI49868.1
RefSeqiNP_001095657.1, NM_001102187.1
XP_005204850.1, XM_005204793.3
UniGeneiBt.8745

Genome annotation databases

EnsembliENSBTAT00000015041; ENSBTAP00000015041; ENSBTAG00000011316
GeneIDi535344
KEGGibta:535344

Similar proteinsi

Entry informationi

Entry nameiZC12A_BOVIN
AccessioniPrimary (citable) accession number: A6QQJ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: August 21, 2007
Last modified: April 25, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health