Reviewed, UniProtKB/Swiss-Prot A6QQ74 (PROD2_BOVIN)

Names and origin

Protein names

Recommended name:
    Probable proline dehydrogenase 2
    EC=1.5.99.8

Gene names

Name:

PRODH2

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	461 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Converts proline to delta-1-pyrroline-5-carboxylate Probable.
Catalytic activity	L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor.
Cofactor	FAD By similarity.
Pathway	Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.
Sequence similarities	Belongs to the proline oxidase family.

Ontologies

Keywords
Biological process	Proline metabolism
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	glutamate biosynthetic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW proline catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	proline dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 461	461	Probable proline dehydrogenase 2		PRO_0000308622

Sequences

	Sequence		Length	Mass (Da)
	A6QQ74-1 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: DF3E394E3AF6356E	FASTA	461	51,262
	10 20 30 40 50 60 MLQACRVLRS RAGPSPGSWQ PLSFDGGAFH LKSIGELTRA LLVLRLCAWP PLVTHGLALQ 70 80 90 100 110 120 AWSQRLLGSR LSGALLRASI YGQFVAGETA EEVRSCVLQL QNLGLRPLLA VPTEEEPDSA 130 140 150 160 170 180 VKTGEAWYEG NLSAMLRCVD LSRGLLETPD PTGNALMQLK MTALMSTRLC KQLTSWVRRP 190 200 210 220 230 240 GDSLELSPER LAEAMDSGQD LQVSCLNTEQ TRHLQASLSR LHRVVQHARA QRVRLLVDAE 250 260 270 280 290 300 YTSLNPALSL LVAALATRWN SSGEGGPWVW NTYQAYLKDT YERLRWDAEA ADRAGLAFGV 310 320 330 340 350 360 KLVRGAYLDK ERETARLQGT EDPTQPDYEA TSQSYSRCLE LMLTQVSHRG PMCHLMVASH 370 380 390 400 410 420 NEDSVRQATK RMWELGIPPD GPVCFGQLLG MCDHVSLALG QAGYAVYKSI PYGSLEEVIP 430 440 450 460 YLIRRAQENR SVLRGARREQ ELLSQELRRR LLGRGLRVSP H

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC149682 mRNA. Translation: AAI49683.1.
RefSeq	NP_001098437.1.
UniGene	Bt.5124
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000031772. Bos taurus. [Contig view]
GeneID	508542.
KEGG	bta:508542.
Family and domain databases
InterPro	IPR002872. Proline_DHase. IPR015659. Proline_oxidase. [Graphical view]
PANTHER	PTHR13914. Proline_oxidase. 1 hit.
Pfam	PF01619. Pro_dh. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PROD2_BOVIN

Accession

Primary (citable) accession number: A6QQ74

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	August 21, 2007
Last modified:	November 25, 2008
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)