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Protein
Submitted name:

CBLC protein

Gene

CBLC

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. signal transducer activity Source: InterPro
  3. ubiquitin-protein transferase activity Source: Ensembl
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. cell surface receptor signaling pathway Source: InterPro
  2. negative regulation of epidermal growth factor-activated receptor activity Source: Ensembl
  3. negative regulation of MAP kinase activity Source: Ensembl
  4. protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
CBLC proteinImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:CBLCImported
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 18

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. nucleus Source: InterPro
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000041264.

Structurei

3D structure databases

SMRiA6QPZ5. Positions 13-319.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Zinc-fingerUniRule annotation

Phylogenomic databases

eggNOGiNOG318595.
GeneTreeiENSGT00390000011617.
HOGENOMiHOG000294176.
HOVERGENiHBG005255.
InParanoidiA6QPZ5.
KOiK04707.
OMAiGQKDGFY.
OrthoDBiEOG73BVCF.
TreeFamiTF314210.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.20.930.20. 1 hit.
3.30.40.10. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR024162. Adaptor_Cbl.
IPR014741. Adaptor_Cbl_EF_hand-like.
IPR003153. Adaptor_Cbl_N_hlx.
IPR014742. Adaptor_Cbl_SH2-like.
IPR024159. Cbl_PTB.
IPR011992. EF-hand-dom_pair.
IPR000980. SH2.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PANTHERiPTHR23007. PTHR23007. 1 hit.
PfamiPF02262. Cbl_N. 1 hit.
PF02761. Cbl_N2. 1 hit.
PF02762. Cbl_N3. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF47668. SSF47668. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS51506. CBL_PTB. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6QPZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAALRGRQ WGESRAFGRA VRLLQRLEEQ CGDPRLSSSP PSLRDLLPRT
60 70 80 90 100
AQLLRQVAQA RREAGGGVPE GPGGPWDFLM VYLANLEAKS RQVAALLPPH
110 120 130 140 150
GRKIANDELF REGSRLRRQL AKLALIFSYM HAELDALFPG GRYCGHTYQL
160 170 180 190 200
TKVSAHTFWR ERCGARCVLP WAEFEAVLCI CHPVEPGSTA LALRSTIDLT
210 220 230 240 250
CSGHVSIFEF DIFTRLFQPW PTLLKNWQLL AVNHPGYMAF LTYDEVQARL
260 270 280 290 300
QTFRDKPGSY IFRPSCTRLG KWAIGYVSSD GSILQTIPLN KPLFQVLLEG
310 320 330 340 350
QKEGFYLYPD GKNHNPDLTE LCHMEPHQHI HVSEEQLQLY WAMDSTFELC
360 370 380 390 400
KICAESNKDV KIEPCGHLLC SRCLAAWLCS DSQTCPFCRC EIKGQEAVSI
410 420 430 440 450
HQFHVSATVE DPEHSSDEEE LEQMAPSGPP LPPRLDLCPK SPSSKGHLNV
460 470 480 490
APPTLPRLRA PLPLPRFWTA ASAPWEVTSS PQAREGARGN S
Length:491
Mass (Da):54,955
Last modified:August 20, 2007 - v1
Checksum:iC3B9DD5706F88E66
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02047337 Genomic DNA. No translation available.
BC149567 mRNA. Translation: AAI49568.1.
RefSeqiNP_001094718.1. NM_001101248.2.
UniGeneiBt.21193.

Genome annotation databases

EnsembliENSBTAT00000043713; ENSBTAP00000041264; ENSBTAG00000009494.
GeneIDi615866.
KEGGibta:615866.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02047337 Genomic DNA. No translation available.
BC149567 mRNA. Translation: AAI49568.1.
RefSeqiNP_001094718.1. NM_001101248.2.
UniGeneiBt.21193.

3D structure databases

SMRiA6QPZ5. Positions 13-319.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000041264.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000043713; ENSBTAP00000041264; ENSBTAG00000009494.
GeneIDi615866.
KEGGibta:615866.

Organism-specific databases

CTDi23624.

Phylogenomic databases

eggNOGiNOG318595.
GeneTreeiENSGT00390000011617.
HOGENOMiHOG000294176.
HOVERGENiHBG005255.
InParanoidiA6QPZ5.
KOiK04707.
OMAiGQKDGFY.
OrthoDBiEOG73BVCF.
TreeFamiTF314210.

Miscellaneous databases

NextBioi20899833.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.20.930.20. 1 hit.
3.30.40.10. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR024162. Adaptor_Cbl.
IPR014741. Adaptor_Cbl_EF_hand-like.
IPR003153. Adaptor_Cbl_N_hlx.
IPR014742. Adaptor_Cbl_SH2-like.
IPR024159. Cbl_PTB.
IPR011992. EF-hand-dom_pair.
IPR000980. SH2.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PANTHERiPTHR23007. PTHR23007. 1 hit.
PfamiPF02262. Cbl_N. 1 hit.
PF02761. Cbl_N2. 1 hit.
PF02762. Cbl_N3. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF47668. SSF47668. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS51506. CBL_PTB. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: HerefordImported.
    Tissue: ThymusImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HerefordImported.
  3. Ensembl
    Submitted (JAN-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: HerefordImported.

Entry informationi

Entry nameiA6QPZ5_BOVIN
AccessioniPrimary (citable) accession number: A6QPZ5
Entry historyi
Integrated into UniProtKB/TrEMBL: August 20, 2007
Last sequence update: August 20, 2007
Last modified: March 31, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.