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Protein

Endoplasmic reticulum aminopeptidase 2

Gene

ERAP2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys (By similarity).By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei194SubstrateBy similarity1
Metal bindingi364Zinc; catalyticPROSITE-ProRule annotation1
Active sitei365Proton acceptorPROSITE-ProRule annotation1
Metal bindingi368Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi387Zinc; catalyticPROSITE-ProRule annotation1
Sitei449Transition state stabilizerBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminopeptidase, Hydrolase, Metalloprotease, Protease
Biological processAdaptive immunity, Immunity
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-BTA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Protein family/group databases

MEROPSiM01.024

Names & Taxonomyi

Protein namesi
Recommended name:
Endoplasmic reticulum aminopeptidase 2 (EC:3.4.11.-)
Gene namesi
Name:ERAP2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Organism-specific databases

VGNCiVGNC:28561 ERAP2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicSequence analysis7
Transmembranei8 – 28Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini29 – 954LumenalSequence analysisAdd BLAST926

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003157181 – 954Endoplasmic reticulum aminopeptidase 2Add BLAST954

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi79N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi113N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi399N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi415 ↔ 454By similarity
Glycosylationi644N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi753 ↔ 760By similarity

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6QPT7
PRIDEiA6QPT7

Expressioni

Gene expression databases

BgeeiENSBTAG00000039275

Interactioni

Subunit structurei

Heterodimer with ERAP1.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001164

Structurei

3D structure databases

ProteinModelPortaliA6QPT7
SMRiA6QPT7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni328 – 332Substrate bindingBy similarity5

Sequence similaritiesi

Belongs to the peptidase M1 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1046 Eukaryota
COG0308 LUCA
GeneTreeiENSGT00760000119082
HOGENOMiHOG000106482
HOVERGENiHBG108296
InParanoidiA6QPT7
KOiK13723
OMAiAKNDDLW
OrthoDBiEOG091G01GH
TreeFamiTF300395

Family and domain databases

CDDicd09601 M1_APN_2, 1 hit
InterProiView protein in InterPro
IPR024571 ERAP1-like_C_dom
IPR033528 ERAP2
IPR034016 M1_APN-typ
IPR001930 Peptidase_M1
IPR014782 Peptidase_M1_N
PANTHERiPTHR11533 PTHR11533, 1 hit
PTHR11533:SF239 PTHR11533:SF239, 1 hit
PfamiView protein in Pfam
PF11838 ERAP1_C, 1 hit
PF01433 Peptidase_M1, 1 hit
PRINTSiPR00756 ALADIPTASE
PROSITEiView protein in PROSITE
PS00142 ZINC_PROTEASE, 1 hit

Sequencei

Sequence statusi: Complete.

A6QPT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANSCRKLIF NIYVVFYCSA VIMPQICICS QFTSSPIDQF NKDPKAFPVA
60 70 80 90 100
TNGEIFPWHE LRLPTVVIPL HYDLLIHPNL TSLDFVASEK IEVLVRDATQ
110 120 130 140 150
FIILHSKDLE ILNASLQSEE DVRYKKPGEN LTVLSYPAHQ QIALLVPEKL
160 170 180 190 200
RAHLRYSVAI DFQAKLADGF EGFYKSTYRT LGGETRTIAV TDFEPTEARM
210 220 230 240 250
AFPCFDEPLF KANFSIKIRR ESRHIALSNM PKVKTIELEG GLLEDHFETT
260 270 280 290 300
VRMSTYLVAY IVCDFTSVSG TASSGVKVSI YASPDKWSQT HYALEASVKL
310 320 330 340 350
LDFYENYFDI HYPLPKLDLV AIPDFASGAM ENWGLITYRE TSLLFDPKTS
360 370 380 390 400
STSDKLWVTK VIAHELAHQW FGNLVTMEWW NDIWLNEGFA RYMELISLNI
410 420 430 440 450
TYPELQFDDS FSNTCFEVIK RDSLNSSHPI SNEAKTATQI KEMFDAVSYN
460 470 480 490 500
KGACILNMLK DFLSEETFRK GIIHYLKKFT YRNAKNDDLW HSLSNNCLEG
510 520 530 540 550
DSTSGGFCYS DSRKTSNTLA FLRENVELKE MMATWTLQKG IPLVVVKREG
560 570 580 590 600
RSLRLQQERF LSGVFKEDPE WGTLQERYLW HIPVTYSTSS SQAIHRHILK
610 620 630 640 650
LKTDTVDLSE KTDWVKFNVD SSGYYIVHYE GQGWDELITL LNQNHTLLRP
660 670 680 690 700
KDRLGLIHDA FQLVSAGRLT LDKALDLTRY LQHETSIPAL LKGLEYLELF
710 720 730 740 750
YRMVERRNIS DVTENLKHYL LQYFKPVIDT QSWLDEGSVW DRMLRSTVLK
760 770 780 790 800
LACYLNHAPC IQKATELFSQ WMESSGKLNI PADVLTIVYS VGAQTTAGWN
810 820 830 840 850
YLLEQYELSL SGAEKNKILY ALSTSKHQEK LMKLIELGME GKVIKTQDLA
860 870 880 890 900
TLLFTTARNP KGQQLAWNFV KENWTHLLKK FELGSFPIRM IISGTTSHFS
910 920 930 940 950
SKDELQEVKL FFESLKAQGS HLDIFQIILE TISKNIKWLE KNLPTLRKWL

LTSI
Length:954
Mass (Da):109,719
Last modified:August 21, 2007 - v1
Checksum:iCC9F28CB1EBFBE2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC149475 mRNA Translation: AAI49476.1
RefSeqiNP_001069096.2, NM_001075628.2
XP_005209817.1, XM_005209760.3
UniGeneiBt.59451

Genome annotation databases

EnsembliENSBTAT00000001164; ENSBTAP00000001164; ENSBTAG00000039275
GeneIDi513572
KEGGibta:513572

Similar proteinsi

Entry informationi

Entry nameiERAP2_BOVIN
AccessioniPrimary (citable) accession number: A6QPT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: March 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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