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Protein

Putative histone-lysine N-methyltransferase PRDM6

Gene

PRDM6

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression.By similarity

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri468 – 490C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri496 – 518C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri524 – 546C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri552 – 574C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Methyltransferase, Repressor, Transferase
Biological processTranscription, Transcription regulation
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative histone-lysine N-methyltransferase PRDM6 (EC:2.1.1.43)
Alternative name(s):
PR domain zinc finger protein 6
PR domain-containing protein 6
Gene namesi
Name:PRDM6
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003639581 – 590Putative histone-lysine N-methyltransferase PRDM6Add BLAST590

Proteomic databases

PaxDbiA6QPM3.

Expressioni

Gene expression databases

BgeeiENSBTAG00000020578.

Interactioni

Subunit structurei

Interacts with HDAC1, HDAC2, HDAC3, CBX1 and EP300.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027421.

Structurei

3D structure databases

ProteinModelPortaliA6QPM3.
SMRiA6QPM3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini241 – 360SETPROSITE-ProRule annotationAdd BLAST120

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi30 – 33Poly-Gly4
Compositional biasi43 – 70Pro-richAdd BLAST28
Compositional biasi94 – 106Poly-AlaAdd BLAST13
Compositional biasi223 – 227Poly-Ala5

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri468 – 490C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri496 – 518C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri524 – 546C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri552 – 574C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
KOG2461. Eukaryota.
ENOG410XRVC. LUCA.
GeneTreeiENSGT00830000128284.
HOGENOMiHOG000090218.
HOVERGENiHBG108289.
InParanoidiA6QPM3.
KOiK20795.
OMAiPPEIPEW.
OrthoDBiEOG091G0A5R.
TreeFamiTF106403.

Family and domain databases

InterProiView protein in InterPro
IPR001214. SET_dom.
IPR013087. Znf_C2H2_type.
PfamiView protein in Pfam
PF00856. SET. 1 hit.
SMARTiView protein in SMART
SM00317. SET. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
SUPFAMiSSF57667. SSF57667. 2 hits.
PROSITEiView protein in PROSITE
PS50280. SET. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.

Sequencei

Sequence statusi: Complete.

A6QPM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKPGDPGGS AFLKVDPAYL QHWQQLFPHG GGGPLKGGGA AGPLGAPQPL
60 70 80 90 100
QPPPPPERAE PQPDSLRPRP ASLSSASSTP ASSSTSASSA SSCAAAAAAA
110 120 130 140 150
AAAALAGLSA LPVAQLPVFA PLATVAAEPL PPKDLCLGAT SGPGPSKCGG
160 170 180 190 200
SGGDGRGVPR FRCSAEELDY YLYGQQRMEI IPLNQHTSDP NNRCDMCADN
210 220 230 240 250
RNGECPMHGP LHSLRRLVGT SSAAAAAPPP ELPEWLRDLP REVCLCTSTV
260 270 280 290 300
PGLAYGICAA QRIQQGTWIG PFQGVLLPPE KVQAGAVRNT QHLWEIYDQD
310 320 330 340 350
GTLQHFIDGG EPSKSSWMRY IRCARHCGEQ NLTVVQYRSN IFYRACIDIP
360 370 380 390 400
RGTELLVWYN DSYTSFFGIP LQCIAQDENL NVPSTVMEAM CRQDALQPFN
410 420 430 440 450
KSSKLSQAPQ QRSVVFPQTP CGRNFSLLDK SGPLESGFNQ ISVKNQRVLA
460 470 480 490 500
SPTSTSQLHS EFSDWHLWKC GQCFKTFTQR ILLQMHVCTQ NPDRPYQCGH
510 520 530 540 550
CSQSFSQPSE LRNHVVTHSS DRPFKCGYCG RAFAGATTLN NHIRTHTGEK
560 570 580 590
PFKCERCERS FTQATQLSRH QRMPNECKPI TESPESIEVD
Length:590
Mass (Da):63,989
Last modified:August 21, 2007 - v1
Checksum:iB7D55FF617059231
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC149387 mRNA. Translation: AAI49388.1.
RefSeqiNP_001096725.1. NM_001103255.2.
UniGeneiBt.36375.

Genome annotation databases

EnsembliENSBTAT00000027421; ENSBTAP00000027421; ENSBTAG00000020578.
GeneIDi519857.
KEGGibta:519857.

Similar proteinsi

Entry informationi

Entry nameiPRDM6_BOVIN
AccessioniPrimary (citable) accession number: A6QPM3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: August 21, 2007
Last modified: August 30, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families