ID   A6QNZ2_BOVIN            Unreviewed;       595 AA.
AC   A6QNZ2; F1MVK3;
DT   21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT   21-AUG-2007, sequence version 1.
DT   27-MAR-2024, entry version 80.
DE   SubName: Full=TGM5 protein {ECO:0000313|EMBL:AAI49071.1};
DE   SubName: Full=Transglutaminase 5 {ECO:0000313|Ensembl:ENSBTAP00000042854.3};
GN   Name=TGM5 {ECO:0000313|EMBL:AAI49071.1,
GN   ECO:0000313|Ensembl:ENSBTAP00000042854.3,
GN   ECO:0000313|VGNC:VGNC:35812};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|EMBL:AAI49071.1};
RN   [1] {ECO:0000313|EMBL:AAI49071.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=L1 Hereford {ECO:0000313|EMBL:AAI49071.1};
RC   TISSUE=Fetal skin {ECO:0000313|EMBL:AAI49071.1};
RA   Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y.,
RA   Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C.,
RA   Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J.,
RA   Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J.,
RA   Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D., Siddiqui A.,
RA   Holt R., Jones S.J., Marra M.A.;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000042854.3, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000042854.3,
RC   ECO:0000313|Proteomes:UP000009136};
RA   Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA   Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA   Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT   "ARS-UCD1.2.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSBTAP00000042854.3}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000042854.3};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the transglutaminase superfamily.
CC       Transglutaminase family. {ECO:0000256|ARBA:ARBA00005968}.
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DR   EMBL; BC149070; AAI49071.1; -; mRNA.
DR   RefSeq; NP_001095479.1; NM_001102009.1.
DR   PaxDb; 9913-ENSBTAP00000042854; -.
DR   Ensembl; ENSBTAT00000045466.3; ENSBTAP00000042854.3; ENSBTAG00000032059.4.
DR   GeneID; 514767; -.
DR   KEGG; bta:514767; -.
DR   CTD; 9333; -.
DR   VEuPathDB; HostDB:ENSBTAG00000032059; -.
DR   VGNC; VGNC:35812; TGM5.
DR   eggNOG; ENOG502QTRA; Eukaryota.
DR   GeneTree; ENSGT01050000244866; -.
DR   HOGENOM; CLU_013435_1_0_1; -.
DR   TreeFam; TF324278; -.
DR   Proteomes; UP000009136; Chromosome 21.
DR   Bgee; ENSBTAG00000032059; Expressed in zone of skin and 30 other cell types or tissues.
DR   GO; GO:0003810; F:protein-glutamine gamma-glutamyltransferase activity; IEA:InterPro.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR002931; Transglutaminase-like.
DR   InterPro; IPR036985; Transglutaminase-like_sf.
DR   InterPro; IPR023608; Transglutaminase_animal.
DR   InterPro; IPR013808; Transglutaminase_AS.
DR   InterPro; IPR008958; Transglutaminase_C.
DR   InterPro; IPR036238; Transglutaminase_C_sf.
DR   InterPro; IPR001102; Transglutaminase_N.
DR   PANTHER; PTHR11590; PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE; 1.
DR   PANTHER; PTHR11590:SF38; PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE 5; 1.
DR   Pfam; PF00927; Transglut_C; 1.
DR   Pfam; PF01841; Transglut_core; 1.
DR   Pfam; PF00868; Transglut_N; 1.
DR   PIRSF; PIRSF000459; TGM_EBP42; 2.
DR   SMART; SM00460; TGc; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   SUPFAM; SSF81296; E set domains; 1.
DR   SUPFAM; SSF49309; Transglutaminase, two C-terminal domains; 2.
DR   PROSITE; PS00547; TRANSGLUTAMINASES; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT   DOMAIN          270..363
FT                   /note="Transglutaminase-like"
FT                   /evidence="ECO:0000259|SMART:SM00460"
FT   ACT_SITE        278
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT   ACT_SITE        337
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT   ACT_SITE        360
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
SQ   SEQUENCE   595 AA;  66689 MW;  F6C1321452AFABA6 CRC64;
     MAEGLEVALT DLQSSWNNVQ HHTDEISSSR LLVRRGQAFN ITLYSRNRAF QPGLDNIIFV
     TETGPLPDLS KGTRAVFSLE GHPGSSPWIA SLQTIGANSL EVSLCAPPMA AVGRYLLKVH
     IKSLQGPVTA YKLGEFILLF NPWCPEDAVY LESEPQRQEY VMNDYGFIYQ GNKNWIRPCP
     WNYGQFEENI IDICLELLDK SLNFQIDPAT DCALRGSPVY ISRVVSAMIN SNDDNGVLNG
     NWGENYSDGT NPTEWMGSVA ILKQWHATGC QPVRYGQCWV FAAVTCTVMR CLGIPTRVIT
     NFNSGHDTDG NLIIDEYYDN TGRILENKKK DSVWNFHVWN ECWMARNDLP PGFGGWQVLD
     ATPQETSNGL YCCGPASVRA IKEGEVDLNY DTAFAFSMVN ADCMAWLVFG GKEQKLHQDT
     STVGNFISTK SIQSDERDDI TENYKYREAK TYPCKITYSQ YSQYLSTDKL IRISALGEEK
     NSPEKILVKK IITLAYPSIV INVLGAAIVN QPLSIQVVFS NPLSEQVEDC VLTVEGSGLF
     RRQQRVLIGV LKPHHRASLT LETIPFKSGQ RQIQANLRSN KFKDIKGYTN VYIGL
//