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Protein

CD320 antigen

Gene

CD320

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for transcobalamin saturated with cobalamin (TCbl). Plays an important role in cobalamin uptake. Plasma membrane protein that is expressed on follicular dendritic cells (FDC) and mediates interaction with germinal center B cells. Functions as costimulator to promote B cell responses to antigenic stimuli; promotes B cell differentiation and proliferation. Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors generated by IL-10.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi71Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi74Calcium 1By similarity1
Metal bindingi76Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi78Calcium 1By similarity1
Metal bindingi84Calcium 1By similarity1
Metal bindingi85Calcium 1By similarity1
Metal bindingi139Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi142Calcium 2By similarity1
Metal bindingi144Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi146Calcium 2By similarity1
Metal bindingi152Calcium 2By similarity1
Metal bindingi153Calcium 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor
LigandMetal-binding

Enzyme and pathway databases

ReactomeiR-BTA-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
CD320 antigen
Alternative name(s):
Transcobalamin receptor
Short name:
TCblR
CD_antigen: CD320
Gene namesi
Name:CD320
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Organism-specific databases

VGNCiVGNC:52223 CD320

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 203ExtracellularSequence analysisAdd BLAST174
Transmembranei204 – 224HelicalSequence analysisAdd BLAST21
Topological domaini225 – 255CytoplasmicSequence analysisAdd BLAST31

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000035405130 – 255CD320 antigenAdd BLAST226

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 66PROSITE-ProRule annotation
Disulfide bondi60 ↔ 79PROSITE-ProRule annotation
Disulfide bondi73 ↔ 88PROSITE-ProRule annotation
Disulfide bondi121 ↔ 134PROSITE-ProRule annotation
Disulfide bondi128 ↔ 147PROSITE-ProRule annotation
Disulfide bondi141 ↔ 156PROSITE-ProRule annotation
Glycosylationi177N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi183N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6QNY1
PRIDEiA6QNY1

Expressioni

Gene expression databases

BgeeiENSBTAG00000004403

Interactioni

Subunit structurei

Interacts (via LDL-receptor class A domains) with TCN2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005777

Structurei

3D structure databases

SMRiA6QNY1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 89LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST38
Domaini120 – 157LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST38

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1215 Eukaryota
ENOG410XP34 LUCA
GeneTreeiENSGT00730000111436
HOGENOMiHOG000111486
HOVERGENiHBG056019
InParanoidiA6QNY1
KOiK06734
OMAiEECRIEP
OrthoDBiEOG091G0M4G
TreeFamiTF337215

Family and domain databases

CDDicd00112 LDLa, 2 hits
InterProiView protein in InterPro
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
PfamiView protein in Pfam
PF00057 Ldl_recept_a, 2 hits
PRINTSiPR00261 LDLRECEPTOR
SMARTiView protein in SMART
SM00192 LDLa, 2 hits
SUPFAMiSSF57424 SSF57424, 2 hits
PROSITEiView protein in PROSITE
PS01209 LDLRA_1, 2 hits
PS50068 LDLRA_2, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6QNY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGWVARGLA RRAAALGLGL RVLLCFGLCL EIAPTPIQTW SPTQAPGPSA
60 70 80 90 100
GSCPPTNFQC RSDGRCLPLI WRCDVDQDCP DGSDEEECGT EVPNGSPSPC
110 120 130 140 150
DIMDDCPDHN KNLLNCGPQS CPEGELCCPL DGVCIPSTWL CDGHRDCSDY
160 170 180 190 200
SDELGCGTKT HEEGRTMSTG TPVTLENVTY LSNATVTAIE DWDSVQSGNR
210 220 230 240 250
NVYGIIAAVA VLSISLAAGI LFALSRLCAQ GCLAPLGLLV SMKGSLQPEK

KTSVL
Length:255
Mass (Da):26,935
Last modified:November 25, 2008 - v2
Checksum:i45CDA7CCBA4DAD8E
GO

Sequence cautioni

The sequence AAI49058 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC149057 mRNA Translation: AAI49058.1 Different initiation.
RefSeqiNP_001160030.1, NM_001166558.1
UniGeneiBt.3785

Genome annotation databases

EnsembliENSBTAT00000005777; ENSBTAP00000005777; ENSBTAG00000004403
GeneIDi505043
KEGGibta:505043

Similar proteinsi

Entry informationi

Entry nameiCD320_BOVIN
AccessioniPrimary (citable) accession number: A6QNY1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 25, 2008
Last modified: April 25, 2018
This is version 71 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health