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Protein

CD320 antigen

Gene

CD320

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for transcobalamin saturated with cobalamin (TCbl). Plays an important role in cobalamin uptake. Plasma membrane protein that is expressed on follicular dendritic cells (FDC) and mediates interaction with germinal center B cells. Functions as costimulator to promote B cell responses to antigenic stimuli; promotes B cell differentiation and proliferation. Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors generated by IL-10.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi71Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi74Calcium 1By similarity1
Metal bindingi76Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi78Calcium 1By similarity1
Metal bindingi84Calcium 1By similarity1
Metal bindingi85Calcium 1By similarity1
Metal bindingi139Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi142Calcium 2By similarity1
Metal bindingi144Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi146Calcium 2By similarity1
Metal bindingi152Calcium 2By similarity1
Metal bindingi153Calcium 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor
LigandMetal-binding

Enzyme and pathway databases

ReactomeiR-BTA-196741. Cobalamin (Cbl, vitamin B12) transport and metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
CD320 antigen
Alternative name(s):
Transcobalamin receptor
Short name:
TCblR
CD_antigen: CD320
Gene namesi
Name:CD320
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Subcellular locationi

  • Cell membrane By similarity; Single-pass type I membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 203ExtracellularSequence analysisAdd BLAST174
Transmembranei204 – 224HelicalSequence analysisAdd BLAST21
Topological domaini225 – 255CytoplasmicSequence analysisAdd BLAST31

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000035405130 – 255CD320 antigenAdd BLAST226

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 66PROSITE-ProRule annotation
Disulfide bondi60 ↔ 79PROSITE-ProRule annotation
Disulfide bondi73 ↔ 88PROSITE-ProRule annotation
Disulfide bondi121 ↔ 134PROSITE-ProRule annotation
Disulfide bondi128 ↔ 147PROSITE-ProRule annotation
Disulfide bondi141 ↔ 156PROSITE-ProRule annotation
Glycosylationi177N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi183N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6QNY1.
PRIDEiA6QNY1.

Expressioni

Gene expression databases

BgeeiENSBTAG00000004403.

Interactioni

Subunit structurei

Interacts (via LDL-receptor class A domains) with TCN2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005777.

Structurei

3D structure databases

SMRiA6QNY1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 89LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST38
Domaini120 – 157LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST38

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1215. Eukaryota.
ENOG410XP34. LUCA.
GeneTreeiENSGT00730000111436.
HOGENOMiHOG000111486.
HOVERGENiHBG056019.
InParanoidiA6QNY1.
KOiK06734.
OMAiEECRIEP.
OrthoDBiEOG091G0M4G.
TreeFamiTF337215.

Family and domain databases

InterProiView protein in InterPro
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
PfamiView protein in Pfam
PF00057. Ldl_recept_a. 2 hits.
PRINTSiPR00261. LDLRECEPTOR.
SMARTiView protein in SMART
SM00192. LDLa. 2 hits.
SUPFAMiSSF57424. SSF57424. 2 hits.
PROSITEiView protein in PROSITE
PS01209. LDLRA_1. 2 hits.
PS50068. LDLRA_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6QNY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGWVARGLA RRAAALGLGL RVLLCFGLCL EIAPTPIQTW SPTQAPGPSA
60 70 80 90 100
GSCPPTNFQC RSDGRCLPLI WRCDVDQDCP DGSDEEECGT EVPNGSPSPC
110 120 130 140 150
DIMDDCPDHN KNLLNCGPQS CPEGELCCPL DGVCIPSTWL CDGHRDCSDY
160 170 180 190 200
SDELGCGTKT HEEGRTMSTG TPVTLENVTY LSNATVTAIE DWDSVQSGNR
210 220 230 240 250
NVYGIIAAVA VLSISLAAGI LFALSRLCAQ GCLAPLGLLV SMKGSLQPEK

KTSVL
Length:255
Mass (Da):26,935
Last modified:November 25, 2008 - v2
Checksum:i45CDA7CCBA4DAD8E
GO

Sequence cautioni

The sequence AAI49058 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC149057 mRNA. Translation: AAI49058.1. Different initiation.
RefSeqiNP_001160030.1. NM_001166558.1.
UniGeneiBt.3785.

Genome annotation databases

EnsembliENSBTAT00000005777; ENSBTAP00000005777; ENSBTAG00000004403.
GeneIDi505043.
KEGGibta:505043.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCD320_BOVIN
AccessioniPrimary (citable) accession number: A6QNY1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 25, 2008
Last modified: May 10, 2017
This is version 68 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome