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Protein

CD320 antigen

Gene

CD320

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors generated by IL-10. Receptor for the cellular uptake of transcobalamin bound cobalamin.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiR-BTA-196741. Cobalamin (Cbl, vitamin B12) transport and metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
CD320 antigen
Alternative name(s):
Transcobalamin receptor
Short name:
TCblR
CD_antigen: CD320
Gene namesi
Name:CD320
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 203174ExtracellularSequence analysisAdd
BLAST
Transmembranei204 – 22421HelicalSequence analysisAdd
BLAST
Topological domaini225 – 25531CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence analysisAdd
BLAST
Chaini30 – 255226CD320 antigenPRO_0000354051Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 66PROSITE-ProRule annotation
Disulfide bondi60 ↔ 79PROSITE-ProRule annotation
Disulfide bondi73 ↔ 88PROSITE-ProRule annotation
Disulfide bondi121 ↔ 134PROSITE-ProRule annotation
Disulfide bondi128 ↔ 147PROSITE-ProRule annotation
Disulfide bondi141 ↔ 156PROSITE-ProRule annotation
Glycosylationi177 – 1771N-linked (GlcNAc...)Sequence analysis
Glycosylationi183 – 1831N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6QNY1.

Expressioni

Gene expression databases

BgeeiENSBTAG00000004403.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005777.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 8938LDL-receptor class A 1PROSITE-ProRule annotationAdd
BLAST
Domaini120 – 15738LDL-receptor class A 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 LDL-receptor class A domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1215. Eukaryota.
ENOG410XP34. LUCA.
GeneTreeiENSGT00730000111436.
HOGENOMiHOG000111486.
HOVERGENiHBG056019.
InParanoidiA6QNY1.
KOiK06734.
OMAiEECRIEP.
OrthoDBiEOG091G0M4G.
TreeFamiTF337215.

Family and domain databases

Gene3Di4.10.400.10. 1 hit.
InterProiIPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view]
PfamiPF00057. Ldl_recept_a. 2 hits.
[Graphical view]
PRINTSiPR00261. LDLRECEPTOR.
SMARTiSM00192. LDLa. 2 hits.
[Graphical view]
SUPFAMiSSF57424. SSF57424. 2 hits.
PROSITEiPS01209. LDLRA_1. 2 hits.
PS50068. LDLRA_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6QNY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGWVARGLA RRAAALGLGL RVLLCFGLCL EIAPTPIQTW SPTQAPGPSA
60 70 80 90 100
GSCPPTNFQC RSDGRCLPLI WRCDVDQDCP DGSDEEECGT EVPNGSPSPC
110 120 130 140 150
DIMDDCPDHN KNLLNCGPQS CPEGELCCPL DGVCIPSTWL CDGHRDCSDY
160 170 180 190 200
SDELGCGTKT HEEGRTMSTG TPVTLENVTY LSNATVTAIE DWDSVQSGNR
210 220 230 240 250
NVYGIIAAVA VLSISLAAGI LFALSRLCAQ GCLAPLGLLV SMKGSLQPEK

KTSVL
Length:255
Mass (Da):26,935
Last modified:November 25, 2008 - v2
Checksum:i45CDA7CCBA4DAD8E
GO

Sequence cautioni

The sequence AAI49058 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC149057 mRNA. Translation: AAI49058.1. Different initiation.
RefSeqiNP_001160030.1. NM_001166558.1.
UniGeneiBt.3785.

Genome annotation databases

EnsembliENSBTAT00000005777; ENSBTAP00000005777; ENSBTAG00000004403.
GeneIDi505043.
KEGGibta:505043.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC149057 mRNA. Translation: AAI49058.1. Different initiation.
RefSeqiNP_001160030.1. NM_001166558.1.
UniGeneiBt.3785.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005777.

Proteomic databases

PaxDbiA6QNY1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000005777; ENSBTAP00000005777; ENSBTAG00000004403.
GeneIDi505043.
KEGGibta:505043.

Organism-specific databases

CTDi51293.

Phylogenomic databases

eggNOGiKOG1215. Eukaryota.
ENOG410XP34. LUCA.
GeneTreeiENSGT00730000111436.
HOGENOMiHOG000111486.
HOVERGENiHBG056019.
InParanoidiA6QNY1.
KOiK06734.
OMAiEECRIEP.
OrthoDBiEOG091G0M4G.
TreeFamiTF337215.

Enzyme and pathway databases

ReactomeiR-BTA-196741. Cobalamin (Cbl, vitamin B12) transport and metabolism.

Gene expression databases

BgeeiENSBTAG00000004403.

Family and domain databases

Gene3Di4.10.400.10. 1 hit.
InterProiIPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view]
PfamiPF00057. Ldl_recept_a. 2 hits.
[Graphical view]
PRINTSiPR00261. LDLRECEPTOR.
SMARTiSM00192. LDLa. 2 hits.
[Graphical view]
SUPFAMiSSF57424. SSF57424. 2 hits.
PROSITEiPS01209. LDLRA_1. 2 hits.
PS50068. LDLRA_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD320_BOVIN
AccessioniPrimary (citable) accession number: A6QNY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 25, 2008
Last modified: September 7, 2016
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.