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Protein

Hexosaminidase D

Gene

HEXDC

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Has hexosaminidase activity.By similarity

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

Enzyme regulationi

Inhibited by O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenylcarbamate (PUGNAc).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei141 – 1411Proton donorBy similarity

GO - Molecular functioni

  1. beta-N-acetylhexosaminidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Hexosaminidase D (EC:3.2.1.52)
Alternative name(s):
Beta-N-acetylhexosaminidase
Beta-hexosaminidase D
Hexosaminidase domain-containing protein
N-acetyl-beta-galactosaminidase
Gene namesi
Name:HEXDC
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Cytoplasm. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Hexosaminidase DPRO_0000316789Add
BLAST

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiA6QNR0.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024186.

Structurei

3D structure databases

ProteinModelPortaliA6QNR0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 20 family.Curated

Phylogenomic databases

eggNOGiNOG72156.
HOGENOMiHOG000047740.
HOVERGENiHBG061201.
InParanoidiA6QNR0.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00728. Glyco_hydro_20. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

A6QNR0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLVHLDLKG APPKVCYLSE IFPLFRALGA NGILIEYEDM FPYEGHLRLL
60 70 80 90 100
RAKHAYSPSE IKEILHLATL NELEVIPLVQ TFGHMEFVLK HEALAHLREV
110 120 130 140 150
ARFPNTLNPH KEESLALVTA MIDQVMELHP GARWFHVGCD EVYYLGEGET
160 170 180 190 200
SRQWLQQEPN SKAKLCLSHM EAVASHMRAR YPTTTPLMWD DMLRDIPEDQ
210 220 230 240 250
LSGSRVPQLV EPVLWDYGAD LDLHGKALLV EKYRKSGFSW LWAASAFKGA
260 270 280 290 300
TGVNQSLTPI EHHLRNHLQW LQVAGSVPAD TLRGIILTGW QRYDHFSVLC
310 320 330 340
ELLPVGIPSL AVCLQALLHG DFAENVKARV ENFLGISSLE EMSFRR
Length:346
Mass (Da):39,284
Last modified:February 5, 2008 - v2
Checksum:i3C83027219F13081
GO

Sequence cautioni

The sequence AAI48959.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC148958 mRNA. Translation: AAI48959.1. Different initiation.
UniGeneiBt.62451.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC148958 mRNA. Translation: AAI48959.1. Different initiation.
UniGeneiBt.62451.

3D structure databases

ProteinModelPortaliA6QNR0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024186.

Proteomic databases

PRIDEiA6QNR0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiNOG72156.
HOGENOMiHOG000047740.
HOVERGENiHBG061201.
InParanoidiA6QNR0.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00728. Glyco_hydro_20. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Colon.

Entry informationi

Entry nameiHEXDC_BOVIN
AccessioniPrimary (citable) accession number: A6QNR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: January 7, 2015
This is version 46 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.