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A6QNR0 (HEXDC_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hexosaminidase D

EC=3.2.1.52
Alternative name(s):
Beta-N-acetylhexosaminidase
Beta-hexosaminidase D
Hexosaminidase domain-containing protein
N-acetyl-beta-galactosaminidase
Gene names
Name:HEXDC
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length346 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Has hexosaminidase activity By similarity.

Catalytic activity

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

Enzyme regulation

Inhibited by O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenylcarbamate (PUGNAc) By similarity.

Subunit structure

Homodimer; disulfide-linked By similarity.

Subcellular location

Cytoplasm. Nucleus By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 20 family.

Sequence caution

The sequence AAI48959.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   Molecular functionGlycosidase
Hydrolase
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcarbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionbeta-N-acetylhexosaminidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 346346Hexosaminidase D
PRO_0000316789

Sites

Active site1411Proton donor By similarity

Sequences

Sequence LengthMass (Da)Tools
A6QNR0 [UniParc].

Last modified February 5, 2008. Version 2.
Checksum: 3C83027219F13081

FASTA34639,284
        10         20         30         40         50         60 
MRLVHLDLKG APPKVCYLSE IFPLFRALGA NGILIEYEDM FPYEGHLRLL RAKHAYSPSE 

        70         80         90        100        110        120 
IKEILHLATL NELEVIPLVQ TFGHMEFVLK HEALAHLREV ARFPNTLNPH KEESLALVTA 

       130        140        150        160        170        180 
MIDQVMELHP GARWFHVGCD EVYYLGEGET SRQWLQQEPN SKAKLCLSHM EAVASHMRAR 

       190        200        210        220        230        240 
YPTTTPLMWD DMLRDIPEDQ LSGSRVPQLV EPVLWDYGAD LDLHGKALLV EKYRKSGFSW 

       250        260        270        280        290        300 
LWAASAFKGA TGVNQSLTPI EHHLRNHLQW LQVAGSVPAD TLRGIILTGW QRYDHFSVLC 

       310        320        330        340 
ELLPVGIPSL AVCLQALLHG DFAENVKARV ENFLGISSLE EMSFRR 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Colon.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC148958 mRNA. Translation: AAI48959.1. Different initiation.
UniGeneBt.62451.

3D structure databases

ProteinModelPortalA6QNR0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000024186.

Proteomic databases

PRIDEA6QNR0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG72156.
HOGENOMHOG000047740.
HOVERGENHBG061201.
InParanoidA6QNR0.

Family and domain databases

Gene3D3.20.20.80. 1 hit.
InterProIPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamPF00728. Glyco_hydro_20. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHEXDC_BOVIN
AccessionPrimary (citable) accession number: A6QNR0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: January 22, 2014
This is version 43 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries