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A6QNR0

- HEXDC_BOVIN

UniProt

A6QNR0 - HEXDC_BOVIN

Protein

Hexosaminidase D

Gene

HEXDC

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 2 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Has hexosaminidase activity.By similarity

    Catalytic activityi

    Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

    Enzyme regulationi

    Inhibited by O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenylcarbamate (PUGNAc).By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei141 – 1411Proton donorBy similarity

    GO - Molecular functioni

    1. beta-N-acetylhexosaminidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hexosaminidase D (EC:3.2.1.52)
    Alternative name(s):
    Beta-N-acetylhexosaminidase
    Beta-hexosaminidase D
    Hexosaminidase domain-containing protein
    N-acetyl-beta-galactosaminidase
    Gene namesi
    Name:HEXDC
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Cytoplasm. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 346346Hexosaminidase DPRO_0000316789Add
    BLAST

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiA6QNR0.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000024186.

    Structurei

    3D structure databases

    ProteinModelPortaliA6QNR0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 20 family.Curated

    Phylogenomic databases

    eggNOGiNOG72156.
    HOGENOMiHOG000047740.
    HOVERGENiHBG061201.
    InParanoidiA6QNR0.

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    InterProiIPR015883. Glyco_hydro_20_cat-core.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF00728. Glyco_hydro_20. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A6QNR0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLVHLDLKG APPKVCYLSE IFPLFRALGA NGILIEYEDM FPYEGHLRLL    50
    RAKHAYSPSE IKEILHLATL NELEVIPLVQ TFGHMEFVLK HEALAHLREV 100
    ARFPNTLNPH KEESLALVTA MIDQVMELHP GARWFHVGCD EVYYLGEGET 150
    SRQWLQQEPN SKAKLCLSHM EAVASHMRAR YPTTTPLMWD DMLRDIPEDQ 200
    LSGSRVPQLV EPVLWDYGAD LDLHGKALLV EKYRKSGFSW LWAASAFKGA 250
    TGVNQSLTPI EHHLRNHLQW LQVAGSVPAD TLRGIILTGW QRYDHFSVLC 300
    ELLPVGIPSL AVCLQALLHG DFAENVKARV ENFLGISSLE EMSFRR 346
    Length:346
    Mass (Da):39,284
    Last modified:February 5, 2008 - v2
    Checksum:i3C83027219F13081
    GO

    Sequence cautioni

    The sequence AAI48959.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC148958 mRNA. Translation: AAI48959.1. Different initiation.
    UniGeneiBt.62451.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC148958 mRNA. Translation: AAI48959.1 . Different initiation.
    UniGenei Bt.62451.

    3D structure databases

    ProteinModelPortali A6QNR0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000024186.

    Proteomic databases

    PRIDEi A6QNR0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi NOG72156.
    HOGENOMi HOG000047740.
    HOVERGENi HBG061201.
    InParanoidi A6QNR0.

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    InterProi IPR015883. Glyco_hydro_20_cat-core.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF00728. Glyco_hydro_20. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Colon.

    Entry informationi

    Entry nameiHEXDC_BOVIN
    AccessioniPrimary (citable) accession number: A6QNR0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3