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Protein

Protein phosphatase 1 regulatory subunit 3B

Gene

PPP1R3B

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCarbohydrate metabolism, Glycogen metabolism

Protein family/group databases

CAZyiCBM21 Carbohydrate-Binding Module Family 21

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 3B
Gene namesi
Name:PPP1R3B
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 27

Organism-specific databases

VGNCiVGNC:33243 PPP1R3B

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003245421 – 284Protein phosphatase 1 regulatory subunit 3BAdd BLAST284

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei260PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA6QNP3
PRIDEiA6QNP3

Expressioni

Gene expression databases

BgeeiENSBTAG00000010606

Interactioni

Subunit structurei

Interacts with glycogen, PPP1CC catalytic subunit of PP1 and PYGL. Associates with glycogen particles. Forms complexes with debranching enzyme, glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000014032

Structurei

3D structure databases

ProteinModelPortaliA6QNP3
SMRiA6QNP3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini124 – 232CBM21PROSITE-ProRule annotationAdd BLAST109

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi61 – 64PP1-binding motif4

Domaini

The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to PYGL.By similarity

Phylogenomic databases

eggNOGiKOG3986 Eukaryota
ENOG4111FT1 LUCA
GeneTreeiENSGT00530000062978
HOGENOMiHOG000026799
HOVERGENiHBG052744
InParanoidiA6QNP3
KOiK07189
OMAiMVKVFSE
OrthoDBiEOG091G0GB5
TreeFamiTF105537

Family and domain databases

Gene3Di2.60.40.2440, 1 hit
InterProiView protein in InterPro
IPR005036 CBM21_dom
IPR038175 CBM21_dom_sf
IPR017434 Pase-1_reg-su_3B/C/D_met
IPR030682 PP1_3B
PANTHERiPTHR12307:SF13 PTHR12307:SF13, 1 hit
PfamiView protein in Pfam
PF03370 CBM_21, 1 hit
PIRSFiPIRSF038207 PP1_GT_animal, 1 hit
PROSITEiView protein in PROSITE
PS51159 CBM21, 1 hit

Sequencei

Sequence statusi: Complete.

A6QNP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVDIECRYS CMAPSLRRER FAFQIAPKPS KPLRPCIQLS GKNEASGTVA
60 70 80 90 100
PTVQEKKVKK RVSFADNQGL ALTMVKVFSE FDDPLDIPLN ITELLDSIVS
110 120 130 140 150
LTTAESESFV LDFSQPSADY LDFRNRLQTD HVCLENCVLK DRSIAGTVKV
160 170 180 190 200
QNLAFEKTVK VRMTFDTWKS FTDFPCWYVK DTYAGSDKDT FSFDISLPEK
210 220 230 240 250
IQSYERMEFA VCYECNGQTY WDSNKGKNYR IIRAELQSTQ GTAQPPNGPD
260 270 280
FEIAFDQFGS PRCSYGLFPE WPSYLGYEKL GPYY
Length:284
Mass (Da):32,383
Last modified:August 21, 2007 - v1
Checksum:i79C2552FC85DA27A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC148936 mRNA Translation: AAI48937.1
RefSeqiNP_001096717.1, NM_001103247.1
UniGeneiBt.59198

Genome annotation databases

EnsembliENSBTAT00000014032; ENSBTAP00000014032; ENSBTAG00000010606
GeneIDi514428
KEGGibta:514428

Similar proteinsi

Entry informationi

Entry nameiPPR3B_BOVIN
AccessioniPrimary (citable) accession number: A6QNP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: August 21, 2007
Last modified: March 28, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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