A6QNM8 (SYTC2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable threonine--tRNA ligase 2, cytoplasmic
EC=6.1.1.3

Alternative name(s):
Threonyl-tRNA synthetase
Short name=ThrRS
Threonyl-tRNA synthetase-like protein 2

Gene names

Name:

TARSL2

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	724 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Domain	Coiled coil
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	threonyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW threonine-tRNA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 724	723	Probable threonine--tRNA ligase 2, cytoplasmic		PRO_0000333827
Regions
	Coiled coil	44 – 72	29	Potential
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6QNM8 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 6B3307FCC4EE0FD8	FASTA	724	83,076
	10 20 30 40 50 60 MAAEALAAEA VASRLARQEE DIRWLWAEVH RLRDEQLNAP DRCQAEGPCL TREVAQLRAE 70 80 90 100 110 120 NRELRHCLYR LRLCLAEELS HQARLESAAR AEAGRAAAGA QPPPSQSLEE DVKKEIDPDN 130 140 150 160 170 180 EVKNPPNFMK ERLKFFEILK KDHQLLLAIY EKKGDSSNVI TVRVADGRTV KGEAWKTTPY 190 200 210 220 230 240 QVAAEISQEL AETTVVAKVN GELWDLDRPL EGDATVELLT FEDEEARAVY WHSSAHVLGE 250 260 270 280 290 300 ALELHYGGLL CCSPPGDGSF HYDVYLEDRA VSSAELPVLE SMCQAIIKEQ QPFERLEVST 310 320 330 340 350 360 KVLLDLFKYN KFKCRILKEK VATPTTTVYR CGPLVELCKG PHVRHTGTIK VIKIFKNSLA 370 380 390 400 410 420 YWADNPEMEM LQRVYGVSFP DEQRMAAWEE LQEEARARDH RTIGKEQELF FFHDLSPGSC 430 440 450 460 470 480 FFLPRGACIY NTLIDFIREQ HHQRNFTEVL SPNMYSCKLW EASGHWQHYS ENMFTFDIDK 490 500 510 520 530 540 DTFALKPMNC PGHCLMFAHR PRSWREMPIR LADFGVLHRN EPSGALSGLT CVRRFQQDDA 550 560 570 580 590 600 HIFCTVGQLE EEIKGCLQFL QSVYSTFGFS FQLNLSTRPE NFLGKIELWD EAEKQLQNSL 610 620 630 640 650 660 MEFGKPWKIN PGEGAFYGPK IDLEIKDALG RYHQCATIQL DFQLPIRFNL TYVSKDGDDK 670 680 690 700 710 720 KNPVIIHQAI LGSVERMIAI LSENYGGKWP FWLSPRQVMV IPVGPTCEKY ALQWLEKRKR QIML

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Hypothalamus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC148906 mRNA. Translation: AAI48907.1.
IPI	IPI00688178.
RefSeq	NP_001095559.1. NM_001102089.1.
UniGene	Bt.36344.
3D structure databases
ProteinModelPortal	A6QNM8.
SMR	A6QNM8. Positions 160-230.
ModBase	Search...
Protein-protein interaction databases
STRING	A6QNM8.
Proteomic databases
PRIDE	A6QNM8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000052449; ENSBTAP00000047958; ENSBTAG00000007651.
GeneID	525350.
KEGG	bta:525350.
Organism-specific databases
CTD	123283.
Phylogenomic databases
eggNOG	maNOG11039.
GeneTree	ENSGT00390000002149.
HOVERGEN	HBG059513.
Family and domain databases
InterPro	IPR002314. aa-tRNA-synt_IIb_cons-dom. IPR006195. aa-tRNA-synth_II. IPR004154. Anticodon-bd. IPR012675. Beta-grasp_ferredoxin-type. IPR004095. TGS. IPR012676. TGS-like. IPR002320. Thr-tRNA-synth_IIa. IPR018163. Thr/Ala-tRNA-synth_IIc_edit. IPR012947. tRNA_SAD. [Graphical view]
Gene3D	G3DSA:3.40.50.800. Anticodon_bd. 1 hit. G3DSA:3.10.20.30. Ferredoxin_fold. 1 hit.
KO	K01868.
Pfam	PF02824. TGS. 1 hit. PF00587. tRNA-synt_2b. 1 hit. PF07973. tRNA_SAD. 1 hit. [Graphical view]
PRINTS	PR01047. TRNASYNTHTHR.
SMART	SM00863. tRNA_SAD. 1 hit. [Graphical view]
SUPFAM	SSF52954. Anticodon_bd. 1 hit. SSF81271. TGS-like. 1 hit. SSF55186. Thr/Ala-tRNA-synth_IIc_edit. 1 hit.
TIGRFAMs	TIGR00418. ThrS. 1 hit.
PROSITE	PS50862. AA_TRNA_LIGASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYTC2_BOVIN

Accession

Primary (citable) accession number: A6QNM8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	August 21, 2007
Last modified:	January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program