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Protein

CX3C chemokine receptor 1

Gene

CX3CR1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the CX3C chemokine fractalkine (CX3CL1); binds to CX3CL1 and mediates both its adhesive and migratory functions.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-BTA-380108. Chemokine receptors bind chemokines.

Names & Taxonomyi

Protein namesi
Recommended name:
CX3C chemokine receptor 1
Short name:
C-X3-C CKR-1
Short name:
CX3CR1
Alternative name(s):
Fractalkine receptor
Gene namesi
Name:CX3CR1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 22

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26ExtracellularSequence analysisAdd BLAST26
Transmembranei27 – 47Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini48 – 68CytoplasmicSequence analysisAdd BLAST21
Transmembranei69 – 89Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini90 – 105ExtracellularSequence analysisAdd BLAST16
Transmembranei106 – 126Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini127 – 147CytoplasmicSequence analysisAdd BLAST21
Transmembranei148 – 168Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini169 – 186ExtracellularSequence analysisAdd BLAST18
Transmembranei187 – 207Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini208 – 232CytoplasmicSequence analysisAdd BLAST25
Transmembranei233 – 253Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini254 – 275ExtracellularSequence analysisAdd BLAST22
Transmembranei276 – 296Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini297 – 358CytoplasmicSequence analysisAdd BLAST62

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003758051 – 358CX3C chemokine receptor 1Add BLAST358

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi103 ↔ 176PROSITE-ProRule annotation
Modified residuei349PhosphothreonineBy similarity1

Post-translational modificationi

This protein is not N-glycosylated which is unusual for G-protein-coupled receptors.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiA6QNL7.

Expressioni

Gene expression databases

BgeeiENSBTAG00000002923.

Interactioni

Subunit structurei

Found in a ternary complex with CX3CL1 and ITGAV:ITGB3 or ITGA4:ITGB1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000003797.

Structurei

3D structure databases

ProteinModelPortaliA6QNL7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGZ8. Eukaryota.
ENOG41118PP. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
InParanoidiA6QNL7.
KOiK04192.
OMAiLPFWTHY.
OrthoDBiEOG091G0D5U.
TreeFamiTF330966.

Family and domain databases

InterProiIPR005387. Chemokine_CX3CR1.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01562. FRACTALKINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6QNL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHTTLPESTS ENFEYYDLAE ACDMGDIVAL GTVFVVILYS LVFAFGLVGN
60 70 80 90 100
LLVVFALINS QRSKSITDIY LLNLALSDLL FVATLPFWTH YVINEQGLHH
110 120 130 140 150
ATCKLITAFF FIGFFGGIFF ITVISVDRFL AIVLAANSMS NRTVQHGVTT
160 170 180 190 200
SLGVWAAAIL VATPQFMFTR EKENECFGDY PEILQEIWPV ILNTEINFLG
210 220 230 240 250
FLLPLLIMSY CYFRIMQTLF SCKNHKKAKA IRLIFLVVVV FFLFWTPYNV
260 270 280 290 300
MIFLQTLNLY DFFPKCDVKR DLKLAISVTE TIAFSHCCLN PLIYAFAGEK
310 320 330 340 350
FRRYLYRLYR KCLAVLCCHP DHLSFSSSLS ESQRSRRESV LSSNFTHYTS

DGDASILL
Length:358
Mass (Da):40,849
Last modified:August 21, 2007 - v1
Checksum:i4F18C530B1118164
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC148890 mRNA. Translation: AAI48891.1.
RefSeqiNP_001096028.1. NM_001102558.2.
XP_010815705.1. XM_010817403.2.
UniGeneiBt.37607.

Genome annotation databases

EnsembliENSBTAT00000003797; ENSBTAP00000003797; ENSBTAG00000002923.
GeneIDi100124525.
KEGGibta:100124525.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC148890 mRNA. Translation: AAI48891.1.
RefSeqiNP_001096028.1. NM_001102558.2.
XP_010815705.1. XM_010817403.2.
UniGeneiBt.37607.

3D structure databases

ProteinModelPortaliA6QNL7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000003797.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiA6QNL7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000003797; ENSBTAP00000003797; ENSBTAG00000002923.
GeneIDi100124525.
KEGGibta:100124525.

Organism-specific databases

CTDi1524.

Phylogenomic databases

eggNOGiENOG410IGZ8. Eukaryota.
ENOG41118PP. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
InParanoidiA6QNL7.
KOiK04192.
OMAiLPFWTHY.
OrthoDBiEOG091G0D5U.
TreeFamiTF330966.

Enzyme and pathway databases

ReactomeiR-BTA-380108. Chemokine receptors bind chemokines.

Gene expression databases

BgeeiENSBTAG00000002923.

Family and domain databases

InterProiIPR005387. Chemokine_CX3CR1.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01562. FRACTALKINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCX3C1_BOVIN
AccessioniPrimary (citable) accession number: A6QNL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: August 21, 2007
Last modified: September 7, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.