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Protein

CX3C chemokine receptor 1

Gene

CX3CR1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for the CX3C chemokine fractalkine (CX3CL1); binds to CX3CL1 and mediates both its adhesive and migratory functions.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-BTA-380108 Chemokine receptors bind chemokines
R-BTA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
CX3C chemokine receptor 1
Short name:
C-X3-C CKR-1
Short name:
CX3CR1
Alternative name(s):
Fractalkine receptor
Gene namesi
Name:CX3CR1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 22

Organism-specific databases

VGNCiVGNC:27845 CX3CR1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26ExtracellularSequence analysisAdd BLAST26
Transmembranei27 – 47Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini48 – 68CytoplasmicSequence analysisAdd BLAST21
Transmembranei69 – 89Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini90 – 105ExtracellularSequence analysisAdd BLAST16
Transmembranei106 – 126Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini127 – 147CytoplasmicSequence analysisAdd BLAST21
Transmembranei148 – 168Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini169 – 186ExtracellularSequence analysisAdd BLAST18
Transmembranei187 – 207Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini208 – 232CytoplasmicSequence analysisAdd BLAST25
Transmembranei233 – 253Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini254 – 275ExtracellularSequence analysisAdd BLAST22
Transmembranei276 – 296Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini297 – 358CytoplasmicSequence analysisAdd BLAST62

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003758051 – 358CX3C chemokine receptor 1Add BLAST358

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi103 ↔ 176PROSITE-ProRule annotation
Modified residuei349PhosphothreonineBy similarity1

Post-translational modificationi

This protein is not N-glycosylated which is unusual for G-protein-coupled receptors.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiA6QNL7
PRIDEiA6QNL7

Expressioni

Gene expression databases

BgeeiENSBTAG00000002923

Interactioni

Subunit structurei

Found in a ternary complex with CX3CL1 and ITGAV:ITGB3 or ITGA4:ITGB1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000003797

Structurei

3D structure databases

ProteinModelPortaliA6QNL7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGZ8 Eukaryota
ENOG41118PP LUCA
GeneTreeiENSGT00760000118785
HOGENOMiHOG000234122
InParanoidiA6QNL7
KOiK04192
OMAiPQFMFTK
OrthoDBiEOG091G0D5U
TreeFamiTF330966

Family and domain databases

CDDicd15186 7tmA_CX3CR1, 1 hit
InterProiView protein in InterPro
IPR005387 Chemokine_CX3CR1
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01562 FRACTALKINER
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

A6QNL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHTTLPESTS ENFEYYDLAE ACDMGDIVAL GTVFVVILYS LVFAFGLVGN
60 70 80 90 100
LLVVFALINS QRSKSITDIY LLNLALSDLL FVATLPFWTH YVINEQGLHH
110 120 130 140 150
ATCKLITAFF FIGFFGGIFF ITVISVDRFL AIVLAANSMS NRTVQHGVTT
160 170 180 190 200
SLGVWAAAIL VATPQFMFTR EKENECFGDY PEILQEIWPV ILNTEINFLG
210 220 230 240 250
FLLPLLIMSY CYFRIMQTLF SCKNHKKAKA IRLIFLVVVV FFLFWTPYNV
260 270 280 290 300
MIFLQTLNLY DFFPKCDVKR DLKLAISVTE TIAFSHCCLN PLIYAFAGEK
310 320 330 340 350
FRRYLYRLYR KCLAVLCCHP DHLSFSSSLS ESQRSRRESV LSSNFTHYTS

DGDASILL
Length:358
Mass (Da):40,849
Last modified:August 21, 2007 - v1
Checksum:i4F18C530B1118164
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC148890 mRNA Translation: AAI48891.1
RefSeqiNP_001096028.1, NM_001102558.2
XP_010815705.1, XM_010817403.2
UniGeneiBt.37607

Genome annotation databases

EnsembliENSBTAT00000003797; ENSBTAP00000003797; ENSBTAG00000002923
GeneIDi100124525
KEGGibta:100124525

Similar proteinsi

Entry informationi

Entry nameiCX3C1_BOVIN
AccessioniPrimary (citable) accession number: A6QNL7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: August 21, 2007
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

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