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Protein

Glutathione peroxidase 7

Gene

GPX7

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei56 – 561By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Enzyme and pathway databases

ReactomeiR-BTA-3299685. Detoxification of Reactive Oxygen Species.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione peroxidase 7 (EC:1.11.1.9)
Short name:
GPx-7
Short name:
GSHPx-7
Gene namesi
Name:GPX7
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 186168Glutathione peroxidase 7PRO_0000317754Add
BLAST

Proteomic databases

PaxDbiA6QLY2.
PRIDEiA6QLY2.

Expressioni

Gene expression databases

BgeeiENSBTAG00000018281.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024329.

Structurei

3D structure databases

ProteinModelPortaliA6QLY2.
SMRiA6QLY2. Positions 22-176.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1651. Eukaryota.
COG0386. LUCA.
GeneTreeiENSGT00760000119230.
HOGENOMiHOG000277054.
HOVERGENiHBG004333.
InParanoidiA6QLY2.
KOiK00432.
OMAiCAQREQD.
OrthoDBiEOG091G0OJG.
TreeFamiTF331942.

Family and domain databases

CDDicd00340. GSH_Peroxidase. 1 hit.
Gene3Di3.40.30.10. 1 hit.
InterProiIPR013376. Glut_perox_Gpx7.
IPR000889. Glutathione_peroxidase.
IPR029759. GPX_AS.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02540. gpx7. 1 hit.
PROSITEiPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6QLY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAARAAAWL LLAAAACAPR EQDFYDFKAV NIRGKLVSLE KYRGSVSLVV
60 70 80 90 100
NVASECGFTD QHYRALQQLQ RDLGPHHFNV LAFPCNQFGQ QEPDSNKEIE
110 120 130 140 150
SFARRTYSVS FPMFSKIAVT GTGAHPAFKY LTETSGKEPT WNFWKYLVAP
160 170 180
DGKVIGAWDP TVSVEEIRPQ ITALVRKLIL KKREDL
Length:186
Mass (Da):20,908
Last modified:August 21, 2007 - v1
Checksum:i6CADF950D7A02E28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC148128 mRNA. Translation: AAI48129.1.
RefSeqiNP_001094583.1. NM_001101113.2.
UniGeneiBt.11662.

Genome annotation databases

EnsembliENSBTAT00000024329; ENSBTAP00000024329; ENSBTAG00000018281.
GeneIDi523311.
KEGGibta:523311.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC148128 mRNA. Translation: AAI48129.1.
RefSeqiNP_001094583.1. NM_001101113.2.
UniGeneiBt.11662.

3D structure databases

ProteinModelPortaliA6QLY2.
SMRiA6QLY2. Positions 22-176.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024329.

Proteomic databases

PaxDbiA6QLY2.
PRIDEiA6QLY2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000024329; ENSBTAP00000024329; ENSBTAG00000018281.
GeneIDi523311.
KEGGibta:523311.

Organism-specific databases

CTDi2882.

Phylogenomic databases

eggNOGiKOG1651. Eukaryota.
COG0386. LUCA.
GeneTreeiENSGT00760000119230.
HOGENOMiHOG000277054.
HOVERGENiHBG004333.
InParanoidiA6QLY2.
KOiK00432.
OMAiCAQREQD.
OrthoDBiEOG091G0OJG.
TreeFamiTF331942.

Enzyme and pathway databases

ReactomeiR-BTA-3299685. Detoxification of Reactive Oxygen Species.

Gene expression databases

BgeeiENSBTAG00000018281.

Family and domain databases

CDDicd00340. GSH_Peroxidase. 1 hit.
Gene3Di3.40.30.10. 1 hit.
InterProiIPR013376. Glut_perox_Gpx7.
IPR000889. Glutathione_peroxidase.
IPR029759. GPX_AS.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02540. gpx7. 1 hit.
PROSITEiPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPX7_BOVIN
AccessioniPrimary (citable) accession number: A6QLY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 21, 2007
Last modified: September 7, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.