Reviewed, UniProtKB/Swiss-Prot A6QLY2 (GPX7_BOVIN)

Names and origin

Protein names

Recommended name:
    Glutathione peroxidase 7
    EC=1.11.1.9

Gene names

Name:

GPX7

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	186 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	2 glutathione + H2O2 = glutathione disulfide + 2 H2O.
Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the glutathione peroxidase family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Oxidoreductase Peroxidase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW response to oxidative stress Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glutathione peroxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 186	168	Glutathione peroxidase 7		PRO_0000317754
Sites
	Active site	56	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6QLY2-1 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 6CADF950D7A02E28	FASTA	186	20,908
	10 20 30 40 50 60 MVAARAAAWL LLAAAACAPR EQDFYDFKAV NIRGKLVSLE KYRGSVSLVV NVASECGFTD 70 80 90 100 110 120 QHYRALQQLQ RDLGPHHFNV LAFPCNQFGQ QEPDSNKEIE SFARRTYSVS FPMFSKIAVT 130 140 150 160 170 180 GTGAHPAFKY LTETSGKEPT WNFWKYLVAP DGKVIGAWDP TVSVEEIRPQ ITALVRKLIL KKREDL

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal cerebellum.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC148128 mRNA. Translation: AAI48129.1.
IPI	IPI00704559.
RefSeq	NP_001094583.1.
UniGene	Bt.11662
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000018281. Bos taurus. [Contig view]
GeneID	523311.
KEGG	bta:523311.
Phylogenomic databases
OMA	A6QLY2. ETSGKEP.
Enzyme and pathway databases
BRENDA	1.11.1.9. 251.
Family and domain databases
InterPro	IPR013376. Glut_perox_Gpx7. IPR000889. Glutathione_peroxidase. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHER	PTHR11592. Glut_peroxidase. 1 hit.
Pfam	PF00255. GSHPx. 1 hit. [Graphical view]
PIRSF	PIRSF000303. Glutathion_perox. 1 hit.
PRINTS	PR01011. GLUTPROXDASE.
TIGRFAMs	TIGR02540. gpx7. 1 hit.
PROSITE	PS00460. GLUTATHIONE_PEROXID_1. 1 hit. PS00763. GLUTATHIONE_PEROXID_2. 1 hit. PS51355. GLUTATHIONE_PEROXID_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPX7_BOVIN

Accession

Primary (citable) accession number: A6QLY2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	August 21, 2007
Last modified:	June 16, 2009
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)