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A6QLU1 (GPDM_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycerol-3-phosphate dehydrogenase, mitochondrial

Short name=GPD-M
Short name=GPDH-M
EC=1.1.5.3
Gene names
Name:GPD2
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length727 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.

Cofactor

FAD By similarity.

Enzyme regulation

Calcium-binding enhance the activity of the enzyme By similarity.

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; glycerone phosphate from sn-glycerol 3-phosphate (aerobic route): step 1/1.

Subcellular location

Mitochondrion By similarity.

Sequence similarities

Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

Contains 2 EF-hand domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 4242Mitochondrion By similarity
Chain43 – 727685Glycerol-3-phosphate dehydrogenase, mitochondrial
PRO_0000355966

Regions

Domain623 – 65836EF-hand 1
Domain659 – 69436EF-hand 2
Nucleotide binding71 – 9929FAD Potential
Calcium binding672 – 68312 Potential

Amino acid modifications

Modified residue6011Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
A6QLU1 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 1F02904CEEA3CC71

FASTA72780,763
        10         20         30         40         50         60 
MAFQKAVKGT ILVGGGALAT VLGLSHFAHY KRKQVNLAFV EAADCISEPV NREPPSREAQ 

        70         80         90        100        110        120 
ILTLKNTSEF DVLVIGGGAT GSGCALDAVT RGLKTALVER DDFSSGTSSR STKLIHGGVR 

       130        140        150        160        170        180 
YLQKAIMKLD IEQYRMVKEA LHERANLLEI APHLSAPLPI MLPIYKWWQL PYYWVGIKLY 

       190        200        210        220        230        240 
DLVAGSNCLK SSYVLSKSRA LEHFPMLQKD KLVGAIVYYD GQHNDARMNL AIALTAARYG 

       250        260        270        280        290        300 
AATANYMEVM SLLKKTDPQT GKERVSGARC KDVLTGEEFD VRAKCVINAT GPFTDTVRKM 

       310        320        330        340        350        360 
DDKDTTAICQ PSAGVHIVMP GYYSPESMGL LDPATSDGRV IFFLPWQKMT IAGTTDTPTD 

       370        380        390        400        410        420 
VTHHPIPSEE DINFILNEVR NYLSCDVEVR RGDVLAAWSG IRPLVTDPKS ADTKSISRNH 

       430        440        450        460        470        480 
VVDISESGLI TIAGGKWTTY RSMAEDTINA AVKAHNLKAG PSRTVGLFLQ GGKDWSPTLY 

       490        500        510        520        530        540 
IRLVQDYGLE SEVAQHLAAT YGDKAFEVAK MASVTGKRWP IVGVRLVSEF PYIEAEVKYG 

       550        560        570        580        590        600 
IKEYACTAVD MISRRTRLAF LNVQAAEEAL PRIVELMGRE LNWDDSKKEE ELETARKFLY 

       610        620        630        640        650        660 
YEMGYKSRSE QLTDRSEISL LPSDIDRYKK RFHKFDADQK GFITIVDVQR VLESIGVQMD 

       670        680        690        700        710        720 
ENTLHEILNE VDLNKNGQVE LNEFLQLMSA IQKGRVSGSR LAILMKTAEE NLDRRVPIPV 


DRSCGGL 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Hypothalamus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC148085 mRNA. Translation: AAI48086.1.
RefSeqNP_001093766.1. NM_001100296.1.
XP_005202470.1. XM_005202413.1.
XP_005202471.1. XM_005202414.1.
UniGeneBt.48365.

3D structure databases

ProteinModelPortalA6QLU1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000012886.

Proteomic databases

PRIDEA6QLU1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000012886; ENSBTAP00000012886; ENSBTAG00000009770.
GeneID504948.
KEGGbta:504948.

Organism-specific databases

CTD2820.

Phylogenomic databases

eggNOGCOG0578.
GeneTreeENSGT00390000001718.
HOGENOMHOG000004813.
HOVERGENHBG005897.
InParanoidA6QLU1.
KOK00111.
OMAKHLTESY.
OrthoDBEOG74TWZ2.
TreeFamTF300359.

Enzyme and pathway databases

UniPathwayUPA00618; UER00674.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR006076. FAD-dep_OxRdtase.
IPR000447. G3P_DH_FAD-dep.
[Graphical view]
PfamPF01266. DAO. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
PRINTSPR01001. FADG3PDH.
SMARTSM00054. EFh. 2 hits.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00977. FAD_G3PDH_1. 1 hit.
PS00978. FAD_G3PDH_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20866901.

Entry information

Entry nameGPDM_BOVIN
AccessionPrimary (citable) accession number: A6QLU1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: August 21, 2007
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways