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A6QLU1

- GPDM_BOVIN

UniProt

A6QLU1 - GPDM_BOVIN

Protein

Glycerol-3-phosphate dehydrogenase, mitochondrial

Gene

GPD2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.

    Cofactori

    FAD.By similarity

    Enzyme regulationi

    Calcium-binding enhance the activity of the enzyme.By similarity

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi71 – 9929FADSequence AnalysisAdd
    BLAST
    Calcium bindingi672 – 68312PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. camera-type eye development Source: Ensembl
    2. gluconeogenesis Source: Ensembl
    3. glycerol-3-phosphate metabolic process Source: Ensembl
    4. glycerol catabolic process Source: UniProtKB-UniPathway
    5. multicellular organism growth Source: Ensembl

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Calcium, FAD, Flavoprotein, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_226458. Fatty acid, triacylglycerol, and ketone body metabolism.
    UniPathwayiUPA00618; UER00674.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycerol-3-phosphate dehydrogenase, mitochondrial (EC:1.1.5.3)
    Short name:
    GPD-M
    Short name:
    GPDH-M
    Gene namesi
    Name:GPD2
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 2

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
    2. mitochondrial inner membrane Source: Ensembl

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4242MitochondrionBy similarityAdd
    BLAST
    Chaini43 – 727685Glycerol-3-phosphate dehydrogenase, mitochondrialPRO_0000355966Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei601 – 6011PhosphotyrosineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiA6QLU1.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000012886.

    Structurei

    3D structure databases

    ProteinModelPortaliA6QLU1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini623 – 65836EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini659 – 69436EF-hand 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transit peptide

    Phylogenomic databases

    eggNOGiCOG0578.
    GeneTreeiENSGT00390000001718.
    HOGENOMiHOG000004813.
    HOVERGENiHBG005897.
    InParanoidiA6QLU1.
    KOiK00111.
    OMAiKHLTESY.
    OrthoDBiEOG74TWZ2.
    TreeFamiTF300359.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR006076. FAD-dep_OxRdtase.
    IPR000447. G3P_DH_FAD-dep.
    [Graphical view]
    PfamiPF01266. DAO. 1 hit.
    PF13499. EF-hand_7. 1 hit.
    [Graphical view]
    PRINTSiPR01001. FADG3PDH.
    SMARTiSM00054. EFh. 2 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 2 hits.
    PS00977. FAD_G3PDH_1. 1 hit.
    PS00978. FAD_G3PDH_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A6QLU1-1 [UniParc]FASTAAdd to Basket

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    MAFQKAVKGT ILVGGGALAT VLGLSHFAHY KRKQVNLAFV EAADCISEPV    50
    NREPPSREAQ ILTLKNTSEF DVLVIGGGAT GSGCALDAVT RGLKTALVER 100
    DDFSSGTSSR STKLIHGGVR YLQKAIMKLD IEQYRMVKEA LHERANLLEI 150
    APHLSAPLPI MLPIYKWWQL PYYWVGIKLY DLVAGSNCLK SSYVLSKSRA 200
    LEHFPMLQKD KLVGAIVYYD GQHNDARMNL AIALTAARYG AATANYMEVM 250
    SLLKKTDPQT GKERVSGARC KDVLTGEEFD VRAKCVINAT GPFTDTVRKM 300
    DDKDTTAICQ PSAGVHIVMP GYYSPESMGL LDPATSDGRV IFFLPWQKMT 350
    IAGTTDTPTD VTHHPIPSEE DINFILNEVR NYLSCDVEVR RGDVLAAWSG 400
    IRPLVTDPKS ADTKSISRNH VVDISESGLI TIAGGKWTTY RSMAEDTINA 450
    AVKAHNLKAG PSRTVGLFLQ GGKDWSPTLY IRLVQDYGLE SEVAQHLAAT 500
    YGDKAFEVAK MASVTGKRWP IVGVRLVSEF PYIEAEVKYG IKEYACTAVD 550
    MISRRTRLAF LNVQAAEEAL PRIVELMGRE LNWDDSKKEE ELETARKFLY 600
    YEMGYKSRSE QLTDRSEISL LPSDIDRYKK RFHKFDADQK GFITIVDVQR 650
    VLESIGVQMD ENTLHEILNE VDLNKNGQVE LNEFLQLMSA IQKGRVSGSR 700
    LAILMKTAEE NLDRRVPIPV DRSCGGL 727
    Length:727
    Mass (Da):80,763
    Last modified:August 21, 2007 - v1
    Checksum:i1F02904CEEA3CC71
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC148085 mRNA. Translation: AAI48086.1.
    RefSeqiNP_001093766.1. NM_001100296.1.
    XP_005202470.1. XM_005202413.1.
    XP_005202471.1. XM_005202414.1.
    UniGeneiBt.48365.

    Genome annotation databases

    EnsembliENSBTAT00000012886; ENSBTAP00000012886; ENSBTAG00000009770.
    GeneIDi504948.
    KEGGibta:504948.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC148085 mRNA. Translation: AAI48086.1 .
    RefSeqi NP_001093766.1. NM_001100296.1.
    XP_005202470.1. XM_005202413.1.
    XP_005202471.1. XM_005202414.1.
    UniGenei Bt.48365.

    3D structure databases

    ProteinModelPortali A6QLU1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000012886.

    Proteomic databases

    PRIDEi A6QLU1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000012886 ; ENSBTAP00000012886 ; ENSBTAG00000009770 .
    GeneIDi 504948.
    KEGGi bta:504948.

    Organism-specific databases

    CTDi 2820.

    Phylogenomic databases

    eggNOGi COG0578.
    GeneTreei ENSGT00390000001718.
    HOGENOMi HOG000004813.
    HOVERGENi HBG005897.
    InParanoidi A6QLU1.
    KOi K00111.
    OMAi KHLTESY.
    OrthoDBi EOG74TWZ2.
    TreeFami TF300359.

    Enzyme and pathway databases

    UniPathwayi UPA00618 ; UER00674 .
    Reactomei REACT_226458. Fatty acid, triacylglycerol, and ketone body metabolism.

    Miscellaneous databases

    NextBioi 20866901.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR006076. FAD-dep_OxRdtase.
    IPR000447. G3P_DH_FAD-dep.
    [Graphical view ]
    Pfami PF01266. DAO. 1 hit.
    PF13499. EF-hand_7. 1 hit.
    [Graphical view ]
    PRINTSi PR01001. FADG3PDH.
    SMARTi SM00054. EFh. 2 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 2 hits.
    PS00977. FAD_G3PDH_1. 1 hit.
    PS00978. FAD_G3PDH_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Hypothalamus.

    Entry informationi

    Entry nameiGPDM_BOVIN
    AccessioniPrimary (citable) accession number: A6QLU1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 16, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3