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A6QLU1

- GPDM_BOVIN

UniProt

A6QLU1 - GPDM_BOVIN

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Protein

Glycerol-3-phosphate dehydrogenase, mitochondrial

Gene

GPD2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.

Cofactori

FADBy similarity

Enzyme regulationi

Calcium-binding enhance the activity of the enzyme.By similarity

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi71 – 9929FADSequence AnalysisAdd
BLAST
Calcium bindingi672 – 68312PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity Source: UniProtKB-EC

GO - Biological processi

  1. camera-type eye development Source: Ensembl
  2. gluconeogenesis Source: Ensembl
  3. glycerol-3-phosphate metabolic process Source: Ensembl
  4. glycerol catabolic process Source: UniProtKB-UniPathway
  5. multicellular organism growth Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Calcium, FAD, Flavoprotein, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_226458. Fatty acid, triacylglycerol, and ketone body metabolism.
UniPathwayiUPA00618; UER00674.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase, mitochondrial (EC:1.1.5.3)
Short name:
GPD-M
Short name:
GPDH-M
Gene namesi
Name:GPD2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 2

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
  2. mitochondrial inner membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4242MitochondrionBy similarityAdd
BLAST
Chaini43 – 727685Glycerol-3-phosphate dehydrogenase, mitochondrialPRO_0000355966Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei601 – 6011PhosphotyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiA6QLU1.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012886.

Structurei

3D structure databases

ProteinModelPortaliA6QLU1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini623 – 65836EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini659 – 69436EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

eggNOGiCOG0578.
GeneTreeiENSGT00390000001718.
HOGENOMiHOG000004813.
HOVERGENiHBG005897.
InParanoidiA6QLU1.
KOiK00111.
OMAiKHLTESY.
OrthoDBiEOG74TWZ2.
TreeFamiTF300359.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR006076. FAD-dep_OxRdtase.
IPR000447. G3P_DH_FAD-dep.
[Graphical view]
PfamiPF01266. DAO. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
PRINTSiPR01001. FADG3PDH.
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00977. FAD_G3PDH_1. 1 hit.
PS00978. FAD_G3PDH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6QLU1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAFQKAVKGT ILVGGGALAT VLGLSHFAHY KRKQVNLAFV EAADCISEPV
60 70 80 90 100
NREPPSREAQ ILTLKNTSEF DVLVIGGGAT GSGCALDAVT RGLKTALVER
110 120 130 140 150
DDFSSGTSSR STKLIHGGVR YLQKAIMKLD IEQYRMVKEA LHERANLLEI
160 170 180 190 200
APHLSAPLPI MLPIYKWWQL PYYWVGIKLY DLVAGSNCLK SSYVLSKSRA
210 220 230 240 250
LEHFPMLQKD KLVGAIVYYD GQHNDARMNL AIALTAARYG AATANYMEVM
260 270 280 290 300
SLLKKTDPQT GKERVSGARC KDVLTGEEFD VRAKCVINAT GPFTDTVRKM
310 320 330 340 350
DDKDTTAICQ PSAGVHIVMP GYYSPESMGL LDPATSDGRV IFFLPWQKMT
360 370 380 390 400
IAGTTDTPTD VTHHPIPSEE DINFILNEVR NYLSCDVEVR RGDVLAAWSG
410 420 430 440 450
IRPLVTDPKS ADTKSISRNH VVDISESGLI TIAGGKWTTY RSMAEDTINA
460 470 480 490 500
AVKAHNLKAG PSRTVGLFLQ GGKDWSPTLY IRLVQDYGLE SEVAQHLAAT
510 520 530 540 550
YGDKAFEVAK MASVTGKRWP IVGVRLVSEF PYIEAEVKYG IKEYACTAVD
560 570 580 590 600
MISRRTRLAF LNVQAAEEAL PRIVELMGRE LNWDDSKKEE ELETARKFLY
610 620 630 640 650
YEMGYKSRSE QLTDRSEISL LPSDIDRYKK RFHKFDADQK GFITIVDVQR
660 670 680 690 700
VLESIGVQMD ENTLHEILNE VDLNKNGQVE LNEFLQLMSA IQKGRVSGSR
710 720
LAILMKTAEE NLDRRVPIPV DRSCGGL
Length:727
Mass (Da):80,763
Last modified:August 21, 2007 - v1
Checksum:i1F02904CEEA3CC71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC148085 mRNA. Translation: AAI48086.1.
RefSeqiNP_001093766.1. NM_001100296.1.
XP_005202470.1. XM_005202413.1.
XP_005202471.1. XM_005202414.1.
UniGeneiBt.48365.

Genome annotation databases

EnsembliENSBTAT00000012886; ENSBTAP00000012886; ENSBTAG00000009770.
GeneIDi504948.
KEGGibta:504948.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC148085 mRNA. Translation: AAI48086.1 .
RefSeqi NP_001093766.1. NM_001100296.1.
XP_005202470.1. XM_005202413.1.
XP_005202471.1. XM_005202414.1.
UniGenei Bt.48365.

3D structure databases

ProteinModelPortali A6QLU1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000012886.

Proteomic databases

PRIDEi A6QLU1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000012886 ; ENSBTAP00000012886 ; ENSBTAG00000009770 .
GeneIDi 504948.
KEGGi bta:504948.

Organism-specific databases

CTDi 2820.

Phylogenomic databases

eggNOGi COG0578.
GeneTreei ENSGT00390000001718.
HOGENOMi HOG000004813.
HOVERGENi HBG005897.
InParanoidi A6QLU1.
KOi K00111.
OMAi KHLTESY.
OrthoDBi EOG74TWZ2.
TreeFami TF300359.

Enzyme and pathway databases

UniPathwayi UPA00618 ; UER00674 .
Reactomei REACT_226458. Fatty acid, triacylglycerol, and ketone body metabolism.

Miscellaneous databases

NextBioi 20866901.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR006076. FAD-dep_OxRdtase.
IPR000447. G3P_DH_FAD-dep.
[Graphical view ]
Pfami PF01266. DAO. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view ]
PRINTSi PR01001. FADG3PDH.
SMARTi SM00054. EFh. 2 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00977. FAD_G3PDH_1. 1 hit.
PS00978. FAD_G3PDH_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Hypothalamus.

Entry informationi

Entry nameiGPDM_BOVIN
AccessioniPrimary (citable) accession number: A6QLU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: August 21, 2007
Last modified: November 26, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3