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A6QLT2 (MTMR2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Myotubularin-related protein 2

EC=3.1.3.-
Gene names
Name:MTMR2
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length643 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate By similarity.

Enzyme regulation

interaction with SBF1 increases phosphatase activity By similarity.

Subunit structure

Homooligomer and heterooligomer. Interacts with SBF1 and SBF2 By similarity.

Subcellular location

Cytoplasm. Early endosome membrane; Peripheral membrane protein. Note: Partly associated with membranes By similarity.

Domain

The coiled-coil domain mediates interaction with SBF2.

Post-translational modification

Phosphorylation at Ser-58 decreases MTMR2 localization to endocytic vesicular structures By similarity.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

Contains 1 GRAM domain.

Contains 1 myotubularin phosphatase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 643643Myotubularin-related protein 2
PRO_0000356227

Regions

Domain68 – 13972GRAM
Domain205 – 580376Myotubularin phosphatase
Region330 – 3334Substrate binding By similarity
Region355 – 3562Substrate binding By similarity
Region417 – 4237Substrate binding By similarity
Coiled coil593 – 62735 Potential
Compositional bias4 – 5350Ser-rich

Sites

Active site4171Phosphocysteine intermediate By similarity
Binding site4631Substrate By similarity

Amino acid modifications

Modified residue61Phosphoserine By similarity
Modified residue581Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
A6QLT2 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 0BF63C1A07DA9895

FASTA64373,348
        10         20         30         40         50         60 
MEKSSSCESL GSQPAVARPP SVDSLSSAST SHSENSVHTK SASVVSSDSI STSAENFSPD 

        70         80         90        100        110        120 
LRVLRESNKL AEMEEPPLLP GENIKDMAKD VTYICPFTGA VRGTLTVTNY RLYFKSMERD 

       130        140        150        160        170        180 
PPFVLDASLG VISRVEKIGG ASSRGENSYG LETVCKDIRN LRFAHKPEGR TRRSIFENLM 

       190        200        210        220        230        240 
KYAFPVSNNL SLFAFEYKEV FPENGWKLYD SLSEYRRQGI PNESWRITKV NERYELCDTY 

       250        260        270        280        290        300 
PALLVVPANI PDEELKRVAS FRSRGRIPVL SWIHPESQAT ITRCSQPMVG VSGKRSKEDE 

       310        320        330        340        350        360 
KYLQAIMDSN AQSHKIFIFD ARPSVNAVAN KAKGGGYESE DAYQNAELVF LDIHNIHVMR 

       370        380        390        400        410        420 
ESLRKLKEIV YPNIEETHWL SNLESTHWLE HIKLILAGAL RIADRVESGK TSVVVHCSDG 

       430        440        450        460        470        480 
WDRTAQLTSL AMLMLDGYYR TIRGFEVLVE KEWLSFGHRF QLRVGHGDKN HADADRSPVF 

       490        500        510        520        530        540 
LQFIDCVWQM TRQFPTAFEF NEYFLITILD HLYSCLFGTF LCNSEQQRGK ENLPRRTVSL 

       550        560        570        580        590        600 
WSYINSQLED FTNPLYGSYS NHVLYPVASM RHLELWVGYY VRWNPRMKPQ EPIHNRYKEL 

       610        620        630        640 
LAKRAELQKK VEELQREISN RSTSSSERAG SPAQCVTPVQ TVV 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Basal ganglia.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC148076 mRNA. Translation: AAI48077.1.
RefSeqNP_001095664.1. NM_001102194.1.
UniGeneBt.28705.

3D structure databases

ProteinModelPortalA6QLT2.
SMRA6QLT2. Positions 73-586.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000022028.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID536810.
KEGGbta:536810.

Organism-specific databases

CTD8898.

Phylogenomic databases

eggNOGNOG322789.
HOGENOMHOG000210598.
HOVERGENHBG000220.
InParanoidA6QLT2.
KOK01112.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
InterProIPR004182. GRAM.
IPR010569. Myotubularin-like_Pase_dom.
IPR011993. PH_like_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PfamPF02893. GRAM. 1 hit.
PF06602. Myotub-related. 1 hit.
[Graphical view]
SMARTSM00568. GRAM. 1 hit.
[Graphical view]
PROSITEPS51339. PPASE_MYOTUBULARIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20877016.

Entry information

Entry nameMTMR2_BOVIN
AccessionPrimary (citable) accession number: A6QLT2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: August 21, 2007
Last modified: April 16, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families