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A6QLT2

- MTMR2_BOVIN

UniProt

A6QLT2 - MTMR2_BOVIN

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Protein

Myotubularin-related protein 2

Gene
MTMR2
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate By similarity.

Enzyme regulationi

interaction with SBF1 increases phosphatase activity By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei417 – 4171Phosphocysteine intermediate By similarity
Binding sitei463 – 4631Substrate By similarity

GO - Molecular functioni

  1. phosphatidylinositol phosphate phosphatase activity Source: Ensembl
  2. protein tyrosine phosphatase activity Source: InterPro

GO - Biological processi

  1. inositol phosphate dephosphorylation Source: Ensembl
  2. myelin assembly Source: Ensembl
  3. negative regulation of myelination Source: Ensembl
  4. neuron development Source: Ensembl
  5. phosphatidylinositol dephosphorylation Source: Ensembl
  6. protein tetramerization Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

ReactomeiREACT_214431. Synthesis of PIPs at the early endosome membrane.
REACT_221945. Synthesis of PIPs at the late endosome membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Myotubularin-related protein 2 (EC:3.1.3.-)
Gene namesi
Name:MTMR2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Cytoplasm. Early endosome membrane; Peripheral membrane protein
Note: Partly associated with membranes By similarity.

GO - Cellular componenti

  1. early endosome membrane Source: UniProtKB-SubCell
  2. nucleus Source: Ensembl
  3. vacuolar membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 643643Myotubularin-related protein 2PRO_0000356227Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei6 – 61Phosphoserine By similarity
Modified residuei58 – 581Phosphoserine By similarity

Post-translational modificationi

Phosphorylation at Ser-58 decreases MTMR2 localization to endocytic vesicular structures By similarity.

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Homooligomer and heterooligomer. Interacts with SBF1 and SBF2 By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022028.

Structurei

3D structure databases

ProteinModelPortaliA6QLT2.
SMRiA6QLT2. Positions 73-586.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 13972GRAMAdd
BLAST
Domaini205 – 580376Myotubularin phosphataseAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni330 – 3334Substrate binding By similarity
Regioni355 – 3562Substrate binding By similarity
Regioni417 – 4237Substrate binding By similarity

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili593 – 62735 Reviewed predictionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi4 – 5350Ser-richAdd
BLAST

Domaini

The coiled-coil domain mediates interaction with SBF2.

Sequence similaritiesi

Contains 1 GRAM domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG322789.
HOGENOMiHOG000210598.
HOVERGENiHBG000220.
InParanoidiA6QLT2.
KOiK18081.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR004182. GRAM.
IPR010569. Myotubularin-like_Pase_dom.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PfamiPF02893. GRAM. 1 hit.
PF06602. Myotub-related. 1 hit.
[Graphical view]
SMARTiSM00568. GRAM. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6QLT2-1 [UniParc]FASTAAdd to Basket

« Hide

MEKSSSCESL GSQPAVARPP SVDSLSSAST SHSENSVHTK SASVVSSDSI    50
STSAENFSPD LRVLRESNKL AEMEEPPLLP GENIKDMAKD VTYICPFTGA 100
VRGTLTVTNY RLYFKSMERD PPFVLDASLG VISRVEKIGG ASSRGENSYG 150
LETVCKDIRN LRFAHKPEGR TRRSIFENLM KYAFPVSNNL SLFAFEYKEV 200
FPENGWKLYD SLSEYRRQGI PNESWRITKV NERYELCDTY PALLVVPANI 250
PDEELKRVAS FRSRGRIPVL SWIHPESQAT ITRCSQPMVG VSGKRSKEDE 300
KYLQAIMDSN AQSHKIFIFD ARPSVNAVAN KAKGGGYESE DAYQNAELVF 350
LDIHNIHVMR ESLRKLKEIV YPNIEETHWL SNLESTHWLE HIKLILAGAL 400
RIADRVESGK TSVVVHCSDG WDRTAQLTSL AMLMLDGYYR TIRGFEVLVE 450
KEWLSFGHRF QLRVGHGDKN HADADRSPVF LQFIDCVWQM TRQFPTAFEF 500
NEYFLITILD HLYSCLFGTF LCNSEQQRGK ENLPRRTVSL WSYINSQLED 550
FTNPLYGSYS NHVLYPVASM RHLELWVGYY VRWNPRMKPQ EPIHNRYKEL 600
LAKRAELQKK VEELQREISN RSTSSSERAG SPAQCVTPVQ TVV 643
Length:643
Mass (Da):73,348
Last modified:August 21, 2007 - v1
Checksum:i0BF63C1A07DA9895
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC148076 mRNA. Translation: AAI48077.1.
RefSeqiNP_001095664.1. NM_001102194.1.
UniGeneiBt.28705.

Genome annotation databases

GeneIDi536810.
KEGGibta:536810.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC148076 mRNA. Translation: AAI48077.1 .
RefSeqi NP_001095664.1. NM_001102194.1.
UniGenei Bt.28705.

3D structure databases

ProteinModelPortali A6QLT2.
SMRi A6QLT2. Positions 73-586.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000022028.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 536810.
KEGGi bta:536810.

Organism-specific databases

CTDi 8898.

Phylogenomic databases

eggNOGi NOG322789.
HOGENOMi HOG000210598.
HOVERGENi HBG000220.
InParanoidi A6QLT2.
KOi K18081.

Enzyme and pathway databases

Reactomei REACT_214431. Synthesis of PIPs at the early endosome membrane.
REACT_221945. Synthesis of PIPs at the late endosome membrane.

Miscellaneous databases

NextBioi 20877016.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR004182. GRAM.
IPR010569. Myotubularin-like_Pase_dom.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view ]
Pfami PF02893. GRAM. 1 hit.
PF06602. Myotub-related. 1 hit.
[Graphical view ]
SMARTi SM00568. GRAM. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS51339. PPASE_MYOTUBULARIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Basal ganglia.

Entry informationi

Entry nameiMTMR2_BOVIN
AccessioniPrimary (citable) accession number: A6QLT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: August 21, 2007
Last modified: September 3, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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