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A6QLT2

- MTMR2_BOVIN

UniProt

A6QLT2 - MTMR2_BOVIN

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Protein

Myotubularin-related protein 2

Gene

MTMR2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (By similarity).By similarity

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate.By similarity
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate.By similarity

Enzyme regulationi

Interaction with SBF1 increases phosphatase activity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei417 – 4171Phosphocysteine intermediatePROSITE-ProRule annotation
Binding sitei463 – 4631SubstrateBy similarity

GO - Molecular functioni

  1. phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity Source: UniProtKB
  2. phosphatidylinositol-3-phosphatase activity Source: UniProtKB
  3. protein tyrosine phosphatase activity Source: InterPro

GO - Biological processi

  1. inositol phosphate dephosphorylation Source: Ensembl
  2. myelin assembly Source: Ensembl
  3. negative regulation of myelination Source: Ensembl
  4. neuron development Source: Ensembl
  5. phosphatidylinositol dephosphorylation Source: UniProtKB
  6. protein tetramerization Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid metabolism

Enzyme and pathway databases

ReactomeiREACT_214431. Synthesis of PIPs at the early endosome membrane.
REACT_221945. Synthesis of PIPs at the late endosome membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Myotubularin-related protein 2
Alternative name(s):
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase (EC:3.1.3.95By similarity)
Phosphatidylinositol-3-phosphate phosphatase (EC:3.1.3.64By similarity)
Gene namesi
Name:MTMR2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Cytoplasm By similarity. Early endosome membrane By similarity; Peripheral membrane protein By similarity
Note: Partly associated with membranes.By similarity

GO - Cellular componenti

  1. cytosol Source: UniProtKB
  2. endosome Source: UniProtKB-KW
  3. nucleus Source: Ensembl
  4. vacuolar membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 643643Myotubularin-related protein 2PRO_0000356227Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei6 – 61PhosphoserineBy similarity
Modified residuei58 – 581PhosphoserineBy similarity

Post-translational modificationi

Phosphorylation at Ser-58 decreases MTMR2 localization to endocytic vesicular structures.By similarity

Keywords - PTMi

Phosphoprotein

Expressioni

Gene expression databases

ExpressionAtlasiA6QLT2. baseline.

Interactioni

Subunit structurei

Homooligomer and heterooligomer. Interacts with SBF1 and SBF2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022028.

Structurei

3D structure databases

ProteinModelPortaliA6QLT2.
SMRiA6QLT2. Positions 73-586.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 13972GRAMAdd
BLAST
Domaini205 – 580376Myotubularin phosphatasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni330 – 3334Substrate bindingBy similarity
Regioni355 – 3562Substrate bindingBy similarity
Regioni417 – 4237Substrate bindingBy similarity

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili593 – 62735Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi4 – 5350Ser-richAdd
BLAST

Domaini

The coiled-coil domain mediates interaction with SBF2.

Sequence similaritiesi

Contains 1 GRAM domain.Curated
Contains 1 myotubularin phosphatase domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG322789.
HOGENOMiHOG000210598.
HOVERGENiHBG000220.
InParanoidiA6QLT2.
KOiK18081.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR004182. GRAM.
IPR010569. Myotubularin-like_Pase_dom.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PfamiPF02893. GRAM. 1 hit.
PF06602. Myotub-related. 1 hit.
[Graphical view]
SMARTiSM00568. GRAM. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6QLT2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKSSSCESL GSQPAVARPP SVDSLSSAST SHSENSVHTK SASVVSSDSI
60 70 80 90 100
STSAENFSPD LRVLRESNKL AEMEEPPLLP GENIKDMAKD VTYICPFTGA
110 120 130 140 150
VRGTLTVTNY RLYFKSMERD PPFVLDASLG VISRVEKIGG ASSRGENSYG
160 170 180 190 200
LETVCKDIRN LRFAHKPEGR TRRSIFENLM KYAFPVSNNL SLFAFEYKEV
210 220 230 240 250
FPENGWKLYD SLSEYRRQGI PNESWRITKV NERYELCDTY PALLVVPANI
260 270 280 290 300
PDEELKRVAS FRSRGRIPVL SWIHPESQAT ITRCSQPMVG VSGKRSKEDE
310 320 330 340 350
KYLQAIMDSN AQSHKIFIFD ARPSVNAVAN KAKGGGYESE DAYQNAELVF
360 370 380 390 400
LDIHNIHVMR ESLRKLKEIV YPNIEETHWL SNLESTHWLE HIKLILAGAL
410 420 430 440 450
RIADRVESGK TSVVVHCSDG WDRTAQLTSL AMLMLDGYYR TIRGFEVLVE
460 470 480 490 500
KEWLSFGHRF QLRVGHGDKN HADADRSPVF LQFIDCVWQM TRQFPTAFEF
510 520 530 540 550
NEYFLITILD HLYSCLFGTF LCNSEQQRGK ENLPRRTVSL WSYINSQLED
560 570 580 590 600
FTNPLYGSYS NHVLYPVASM RHLELWVGYY VRWNPRMKPQ EPIHNRYKEL
610 620 630 640
LAKRAELQKK VEELQREISN RSTSSSERAG SPAQCVTPVQ TVV
Length:643
Mass (Da):73,348
Last modified:August 21, 2007 - v1
Checksum:i0BF63C1A07DA9895
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC148076 mRNA. Translation: AAI48077.1.
RefSeqiNP_001095664.1. NM_001102194.1.
UniGeneiBt.28705.

Genome annotation databases

GeneIDi536810.
KEGGibta:536810.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC148076 mRNA. Translation: AAI48077.1 .
RefSeqi NP_001095664.1. NM_001102194.1.
UniGenei Bt.28705.

3D structure databases

ProteinModelPortali A6QLT2.
SMRi A6QLT2. Positions 73-586.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000022028.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 536810.
KEGGi bta:536810.

Organism-specific databases

CTDi 8898.

Phylogenomic databases

eggNOGi NOG322789.
HOGENOMi HOG000210598.
HOVERGENi HBG000220.
InParanoidi A6QLT2.
KOi K18081.

Enzyme and pathway databases

Reactomei REACT_214431. Synthesis of PIPs at the early endosome membrane.
REACT_221945. Synthesis of PIPs at the late endosome membrane.

Miscellaneous databases

NextBioi 20877016.

Gene expression databases

ExpressionAtlasi A6QLT2. baseline.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR004182. GRAM.
IPR010569. Myotubularin-like_Pase_dom.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view ]
Pfami PF02893. GRAM. 1 hit.
PF06602. Myotub-related. 1 hit.
[Graphical view ]
SMARTi SM00568. GRAM. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS51339. PPASE_MYOTUBULARIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Basal ganglia.

Entry informationi

Entry nameiMTMR2_BOVIN
AccessioniPrimary (citable) accession number: A6QLT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: August 21, 2007
Last modified: October 29, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3