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Protein

Mitogen-activated protein kinase

Gene

MAPK14

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

Cofactori

Mg2+SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseSAAS annotation, Transferase
LigandATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-BTA-168638. NOD1/2 Signaling Pathway.
R-BTA-171007. p38MAPK events.
R-BTA-198753. ERK/MAPK targets.
R-BTA-2559580. Oxidative Stress Induced Senescence.
R-BTA-375170. CDO in myogenesis.
R-BTA-376172. DSCAM interactions.
R-BTA-418592. ADP signalling through P2Y purinoceptor 1.
R-BTA-432142. Platelet sensitization by LDL.
R-BTA-4420097. VEGFA-VEGFR2 Pathway.
R-BTA-450302. activated TAK1 mediates p38 MAPK activation.
R-BTA-450341. Activation of the AP-1 family of transcription factors.
R-BTA-6798695. Neutrophil degranulation.
R-BTA-6804756. Regulation of TP53 Activity through Phosphorylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinaseSAAS annotation (EC:2.7.11.24SAAS annotation)
Gene namesi
Name:MAPK14Imported
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 23

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSBTAG00000020783.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000023988.

Structurei

3D structure databases

SMRiA6QLR9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 308Protein kinaseInterPro annotationAdd BLAST285

Phylogenomic databases

eggNOGiKOG0660. Eukaryota.
ENOG410XNY0. LUCA.
GeneTreeiENSGT00550000074271.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
KOiK04441.
OMAiEQFQQVY.
OrthoDBiEOG091G08QL.
TreeFamiTF105100.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008352. MAPK_p38.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
PRINTSiPR01773. P38MAPKINASE.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.

Sequencei

Sequence statusi: Complete.

A6QLR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQERPTFYR QELNKTIWEV PERYQNLSPV GSGAYGSVCA AFDTKTGLRV
60 70 80 90 100
AVKKLSRPFQ SIIHAKRTYR ELRLLKHMKH ENVIGLLDVF TPARSLEEFN
110 120 130 140 150
DVYLVTHLMG ADLNNIVKCQ KLTDDHVQFL IYQILRGLKY IHSADIIHRD
160 170 180 190 200
LKPSNLAVNE DCELKILDFG LARHTDDEMT GYVATRWYRA PEIMLNWMHY
210 220 230 240 250
NQTVDIWSVG CIMAELLTGR TLFPGTDHIN QLQQIMRLTG TPPAYLINRM
260 270 280 290 300
PSHEARNYIQ SLTQMPKMNF ANVFIGANPL AVDLLEKMLV LDSDKRITAA
310 320 330 340 350
QALAHAYFAQ YHDPDDEPVA DPYDQSFESR DLLIDEWKSL TYDEVISFVP
360
PPLDQEEMES
Length:360
Mass (Da):41,493
Last modified:August 21, 2007 - v1
Checksum:i062EBC3E56683D14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02054970 Genomic DNA. No translation available.
DAAA02054971 Genomic DNA. No translation available.
DAAA02054972 Genomic DNA. No translation available.
DAAA02054973 Genomic DNA. No translation available.
BC148063 mRNA. Translation: AAI48064.1.
RefSeqiNP_001095644.1. NM_001102174.1.
UniGeneiBt.11377.

Genome annotation databases

EnsembliENSBTAT00000023988; ENSBTAP00000023988; ENSBTAG00000020783.
GeneIDi534492.
KEGGibta:534492.

Similar proteinsi

Entry informationi

Entry nameiA6QLR9_BOVIN
AccessioniPrimary (citable) accession number: A6QLR9
Entry historyiIntegrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: September 27, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported