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Protein

Mitogen-activated protein kinase

Gene

MAPK14

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

Cofactori

Mg2+SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-BTA-168638. NOD1/2 Signaling Pathway.
R-BTA-171007. p38MAPK events.
R-BTA-198753. ERK/MAPK targets.
R-BTA-2559580. Oxidative Stress Induced Senescence.
R-BTA-375170. CDO in myogenesis.
R-BTA-376172. DSCAM interactions.
R-BTA-418592. ADP signalling through P2Y purinoceptor 1.
R-BTA-432142. Platelet sensitization by LDL.
R-BTA-4420097. VEGFA-VEGFR2 Pathway.
R-BTA-450302. activated TAK1 mediates p38 MAPK activation.
R-BTA-450341. Activation of the AP-1 family of transcription factors.
R-BTA-6804756. Regulation of TP53 Activity through Phosphorylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinaseSAAS annotation (EC:2.7.11.24SAAS annotation)
Gene namesi
Name:MAPK14Imported
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 23

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000023988.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 308285Protein kinaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains protein kinase domain.SAAS annotation

Phylogenomic databases

eggNOGiKOG0660. Eukaryota.
ENOG410XNY0. LUCA.
GeneTreeiENSGT00550000074271.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
KOiK04441.
OMAiKISSESX.
OrthoDBiEOG7PCJGV.
TreeFamiTF105100.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008352. MAPK_p38.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01773. P38MAPKINASE.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6QLR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQERPTFYR QELNKTIWEV PERYQNLSPV GSGAYGSVCA AFDTKTGLRV
60 70 80 90 100
AVKKLSRPFQ SIIHAKRTYR ELRLLKHMKH ENVIGLLDVF TPARSLEEFN
110 120 130 140 150
DVYLVTHLMG ADLNNIVKCQ KLTDDHVQFL IYQILRGLKY IHSADIIHRD
160 170 180 190 200
LKPSNLAVNE DCELKILDFG LARHTDDEMT GYVATRWYRA PEIMLNWMHY
210 220 230 240 250
NQTVDIWSVG CIMAELLTGR TLFPGTDHIN QLQQIMRLTG TPPAYLINRM
260 270 280 290 300
PSHEARNYIQ SLTQMPKMNF ANVFIGANPL AVDLLEKMLV LDSDKRITAA
310 320 330 340 350
QALAHAYFAQ YHDPDDEPVA DPYDQSFESR DLLIDEWKSL TYDEVISFVP
360
PPLDQEEMES
Length:360
Mass (Da):41,493
Last modified:August 21, 2007 - v1
Checksum:i062EBC3E56683D14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02054970 Genomic DNA. No translation available.
DAAA02054971 Genomic DNA. No translation available.
DAAA02054972 Genomic DNA. No translation available.
DAAA02054973 Genomic DNA. No translation available.
BC148063 mRNA. Translation: AAI48064.1.
RefSeqiNP_001095644.1. NM_001102174.1.
UniGeneiBt.11377.

Genome annotation databases

EnsembliENSBTAT00000023988; ENSBTAP00000023988; ENSBTAG00000020783.
GeneIDi534492.
KEGGibta:534492.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02054970 Genomic DNA. No translation available.
DAAA02054971 Genomic DNA. No translation available.
DAAA02054972 Genomic DNA. No translation available.
DAAA02054973 Genomic DNA. No translation available.
BC148063 mRNA. Translation: AAI48064.1.
RefSeqiNP_001095644.1. NM_001102174.1.
UniGeneiBt.11377.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000023988.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000023988; ENSBTAP00000023988; ENSBTAG00000020783.
GeneIDi534492.
KEGGibta:534492.

Organism-specific databases

CTDi1432.

Phylogenomic databases

eggNOGiKOG0660. Eukaryota.
ENOG410XNY0. LUCA.
GeneTreeiENSGT00550000074271.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
KOiK04441.
OMAiKISSESX.
OrthoDBiEOG7PCJGV.
TreeFamiTF105100.

Enzyme and pathway databases

ReactomeiR-BTA-168638. NOD1/2 Signaling Pathway.
R-BTA-171007. p38MAPK events.
R-BTA-198753. ERK/MAPK targets.
R-BTA-2559580. Oxidative Stress Induced Senescence.
R-BTA-375170. CDO in myogenesis.
R-BTA-376172. DSCAM interactions.
R-BTA-418592. ADP signalling through P2Y purinoceptor 1.
R-BTA-432142. Platelet sensitization by LDL.
R-BTA-4420097. VEGFA-VEGFR2 Pathway.
R-BTA-450302. activated TAK1 mediates p38 MAPK activation.
R-BTA-450341. Activation of the AP-1 family of transcription factors.
R-BTA-6804756. Regulation of TP53 Activity through Phosphorylation.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008352. MAPK_p38.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01773. P38MAPKINASE.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: L1 HerefordImported.
    Tissue: Basal gangliaImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HerefordImported.
  3. Ensembl
    Submitted (MAR-2016) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: HerefordImported.

Entry informationi

Entry nameiA6QLR9_BOVIN
AccessioniPrimary (citable) accession number: A6QLR9
Entry historyi
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: July 6, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.