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Protein

Poly(U)-specific endoribonuclease

Gene

ENDOU

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2'-3'-cyclic phosphate termini.By similarity

Cofactori

Mn2+By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease, RNA-binding
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Poly(U)-specific endoribonuclease (EC:3.1.-.-)
Alternative name(s):
Protein endoU
Uridylate-specific endoribonuclease
Gene namesi
Name:ENDOU
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000039422119 – 413Poly(U)-specific endoribonucleaseAdd BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 40AlternatePROSITE-ProRule annotation
Disulfide bondi24 ↔ 28AlternatePROSITE-ProRule annotation
Disulfide bondi28 ↔ 58AlternatePROSITE-ProRule annotation
Disulfide bondi38 ↔ 51AlternatePROSITE-ProRule annotation
Disulfide bondi38 ↔ 40AlternatePROSITE-ProRule annotation
Disulfide bondi44 ↔ 50PROSITE-ProRule annotation
Disulfide bondi51 ↔ 58AlternatePROSITE-ProRule annotation
Disulfide bondi92 ↔ 108AlternatePROSITE-ProRule annotation
Disulfide bondi92 ↔ 96AlternatePROSITE-ProRule annotation
Disulfide bondi96 ↔ 126AlternatePROSITE-ProRule annotation
Disulfide bondi106 ↔ 119AlternatePROSITE-ProRule annotation
Disulfide bondi106 ↔ 108AlternatePROSITE-ProRule annotation
Disulfide bondi112 ↔ 118PROSITE-ProRule annotation
Disulfide bondi119 ↔ 126AlternatePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiA6QLQ8.

Expressioni

Gene expression databases

BgeeiENSBTAG00000012275.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000043168.

Structurei

3D structure databases

ProteinModelPortaliA6QLQ8.
SMRiA6QLQ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 63SMB 1PROSITE-ProRule annotationAdd BLAST44
Domaini88 – 130SMB 2PROSITE-ProRule annotationAdd BLAST43

Sequence similaritiesi

Belongs to the ENDOU family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG2849. Eukaryota.
ENOG410XX8E. LUCA.
GeneTreeiENSGT00530000063825.
HOGENOMiHOG000247015.
HOVERGENiHBG008236.
InParanoidiA6QLQ8.
KOiK14648.
OMAiRCQEFGN.
OrthoDBiEOG091G0D8U.
TreeFamiTF319848.

Family and domain databases

InterProiView protein in InterPro
IPR018998. EndoU.
IPR037227. EndoU-like.
IPR036024. Somatomedin_B-like_dom_sf.
IPR020436. Somatomedin_B_chordata.
IPR001212. Somatomedin_B_dom.
PfamiView protein in Pfam
PF01033. Somatomedin_B. 2 hits.
PF09412. XendoU. 1 hit.
PRINTSiPR00022. SOMATOMEDINB.
SMARTiView protein in SMART
SM00201. SO. 2 hits.
SUPFAMiSSF142877. SSF142877. 1 hit.
SSF90188. SSF90188. 2 hits.
PROSITEiView protein in PROSITE
PS00524. SMB_1. 2 hits.
PS50958. SMB_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6QLQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRACVPLTVA ILCGLAWAGK RESCASRCNE RFDRDAVCQC DRRCPQHGDC
60 70 80 90 100
CEDYEQLCTA EENPKEPELF LELEEETEGA PASSLYLAPN SCQGRCLEAF
110 120 130 140 150
DKHHSCHCNA RCPEFGNCCE DFESLCGHEG FSHSSDAITK EELQSVSEKI
160 170 180 190 200
YRADTNKARK EDIVLNSQNC ISPSETRDQV DRCPEPLFTY VNEKLFSKPT
210 220 230 240 250
YSAFLNLLNN YQRATGRGEH FTAQELAEQD TFLREIMKTA VMKELYGFLH
260 270 280 290 300
QQNRYSSEQE FVSDLKNMWF GLYSRSKEER DSSGFEHVFS GEVKKGKVTG
310 320 330 340 350
FHNWIRFYMQ EKEGLVDYYS HIYDGPWDSY PDVLAMQFNW DGYYKEVGSA
360 370 380 390 400
FIGSSPEFEF ALYSLCFIAR PGKVCQLSLG GHPLAIQTYT WNKSTYGNGK
410
KYIATAYVVS STH
Length:413
Mass (Da):47,188
Last modified:August 21, 2007 - v1
Checksum:iECBC928F474B51FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC148052 mRNA. Translation: AAI48053.1.
RefSeqiNP_001095560.1. NM_001102090.1.
UniGeneiBt.61409.

Genome annotation databases

EnsembliENSBTAT00000045807; ENSBTAP00000043168; ENSBTAG00000012275.
GeneIDi525399.
KEGGibta:525399.

Similar proteinsi

Entry informationi

Entry nameiENDOU_BOVIN
AccessioniPrimary (citable) accession number: A6QLQ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: August 21, 2007
Last modified: November 22, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families