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Protein

GRB2-related adapter protein

Gene

GRAP

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
GRB2-related adapter protein
Gene namesi
Name:GRAP
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 19

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 217217GRB2-related adapter proteinPRO_0000344237Add
BLAST

Interactioni

Subunit structurei

Associates through its SH2 domain with ligand-activated receptors for stem cell factor (KIT) and erythropoietin (EPOR). Also forms a stable complex with the Bcr-Abl oncoprotein. GRAP is associated with the Ras guanine nucleotide exchange factor SOS1, primarily through its N-terminal SH3 domain. Interacts with phosphorylated LAT upon TCR activation. Interacts with SHB (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000041340.

Structurei

3D structure databases

ProteinModelPortaliA6QLK6.
SMRiA6QLK6. Positions 1-158.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 5858SH3 1PROSITE-ProRule annotationAdd
BLAST
Domaini60 – 15293SH2PROSITE-ProRule annotationAdd
BLAST
Domaini156 – 21560SH3 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the GRB2/sem-5/DRK family.Curated
Contains 1 SH2 domain.PROSITE-ProRule annotation
Contains 2 SH3 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH2 domain, SH3 domain

Phylogenomic databases

eggNOGiNOG298780.
GeneTreeiENSGT00550000074482.
HOGENOMiHOG000251625.
HOVERGENiHBG005404.
InParanoidiA6QLK6.
OMAiRACFAQA.
OrthoDBiEOG75F4F6.
TreeFamiTF354288.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
PS50002. SH3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6QLK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESVALYSFQ ATESDELAFN KGDTLKILNM EDDQNWYKAE LRGAEGFVPK
60 70 80 90 100
NYIRLKPHPW YSGRISRQLA EEILMKRNHQ GAFLIRESES SPGEFSVSVN
110 120 130 140 150
YGDQVQHFKV LRDPSGKYYL WEEKFNSLNE LVAFYRTTTI AKKRQVFLQD
160 170 180 190 200
EEPLPKPPRA CFAQAQFDFS AQDPSQLSFR RGDIIEVLER LDPSWWRGRL
210
SGRIGFFPRS YVQPVHM
Length:217
Mass (Da):25,367
Last modified:August 21, 2007 - v1
Checksum:i11EEB0D6F7122D41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC147998 mRNA. Translation: AAI47999.1.
RefSeqiNP_001095643.1. NM_001102173.1.
XP_010814339.1. XM_010816037.1.
UniGeneiBt.20119.

Genome annotation databases

EnsembliENSBTAT00000043796; ENSBTAP00000041340; ENSBTAG00000003707.
GeneIDi534491.
KEGGibta:534491.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC147998 mRNA. Translation: AAI47999.1.
RefSeqiNP_001095643.1. NM_001102173.1.
XP_010814339.1. XM_010816037.1.
UniGeneiBt.20119.

3D structure databases

ProteinModelPortaliA6QLK6.
SMRiA6QLK6. Positions 1-158.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000041340.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000043796; ENSBTAP00000041340; ENSBTAG00000003707.
GeneIDi534491.
KEGGibta:534491.

Organism-specific databases

CTDi10750.

Phylogenomic databases

eggNOGiNOG298780.
GeneTreeiENSGT00550000074482.
HOGENOMiHOG000251625.
HOVERGENiHBG005404.
InParanoidiA6QLK6.
OMAiRACFAQA.
OrthoDBiEOG75F4F6.
TreeFamiTF354288.

Miscellaneous databases

NextBioi20876418.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
PS50002. SH3. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Basal ganglia.

Entry informationi

Entry nameiGRAP_BOVIN
AccessioniPrimary (citable) accession number: A6QLK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: August 21, 2007
Last modified: March 4, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.