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A6QLK6

- GRAP_BOVIN

UniProt

A6QLK6 - GRAP_BOVIN

Protein

GRB2-related adapter protein

Gene

GRAP

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GRB2-related adapter protein
    Gene namesi
    Name:GRAP
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 19

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 217217GRB2-related adapter proteinPRO_0000344237Add
    BLAST

    Interactioni

    Subunit structurei

    Associates through its SH2 domain with ligand-activated receptors for stem cell factor (KIT) and erythropoietin (EPOR). Also forms a stable complex with the Bcr-Abl oncoprotein. GRAP is associated with the Ras guanine nucleotide exchange factor SOS1, primarily through its N-terminal SH3 domain. Interacts with phosphorylated LAT upon TCR activation. Interacts with SHB By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000041340.

    Structurei

    3D structure databases

    ProteinModelPortaliA6QLK6.
    SMRiA6QLK6. Positions 1-158.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 5858SH3 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini60 – 15293SH2PROSITE-ProRule annotationAdd
    BLAST
    Domaini156 – 21560SH3 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the GRB2/sem-5/DRK family.Curated
    Contains 1 SH2 domain.PROSITE-ProRule annotation
    Contains 2 SH3 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, SH2 domain, SH3 domain

    Phylogenomic databases

    eggNOGiNOG298780.
    GeneTreeiENSGT00550000074482.
    HOGENOMiHOG000251625.
    HOVERGENiHBG005404.
    InParanoidiA6QLK6.
    OMAiRACFAQA.
    OrthoDBiEOG75F4F6.
    TreeFamiTF354288.

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    InterProiIPR000980. SH2.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    PF07653. SH3_2. 1 hit.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    PR00452. SH3DOMAIN.
    SMARTiSM00252. SH2. 1 hit.
    SM00326. SH3. 2 hits.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 2 hits.
    SSF55550. SSF55550. 1 hit.
    PROSITEiPS50001. SH2. 1 hit.
    PS50002. SH3. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6QLK6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESVALYSFQ ATESDELAFN KGDTLKILNM EDDQNWYKAE LRGAEGFVPK    50
    NYIRLKPHPW YSGRISRQLA EEILMKRNHQ GAFLIRESES SPGEFSVSVN 100
    YGDQVQHFKV LRDPSGKYYL WEEKFNSLNE LVAFYRTTTI AKKRQVFLQD 150
    EEPLPKPPRA CFAQAQFDFS AQDPSQLSFR RGDIIEVLER LDPSWWRGRL 200
    SGRIGFFPRS YVQPVHM 217
    Length:217
    Mass (Da):25,367
    Last modified:August 21, 2007 - v1
    Checksum:i11EEB0D6F7122D41
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC147998 mRNA. Translation: AAI47999.1.
    RefSeqiNP_001095643.1. NM_001102173.1.
    UniGeneiBt.20119.

    Genome annotation databases

    EnsembliENSBTAT00000043796; ENSBTAP00000041340; ENSBTAG00000003707.
    GeneIDi534491.
    KEGGibta:534491.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC147998 mRNA. Translation: AAI47999.1 .
    RefSeqi NP_001095643.1. NM_001102173.1.
    UniGenei Bt.20119.

    3D structure databases

    ProteinModelPortali A6QLK6.
    SMRi A6QLK6. Positions 1-158.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000041340.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000043796 ; ENSBTAP00000041340 ; ENSBTAG00000003707 .
    GeneIDi 534491.
    KEGGi bta:534491.

    Organism-specific databases

    CTDi 10750.

    Phylogenomic databases

    eggNOGi NOG298780.
    GeneTreei ENSGT00550000074482.
    HOGENOMi HOG000251625.
    HOVERGENi HBG005404.
    InParanoidi A6QLK6.
    OMAi RACFAQA.
    OrthoDBi EOG75F4F6.
    TreeFami TF354288.

    Miscellaneous databases

    NextBioi 20876418.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    InterProi IPR000980. SH2.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    PF07653. SH3_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    PR00452. SH3DOMAIN.
    SMARTi SM00252. SH2. 1 hit.
    SM00326. SH3. 2 hits.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 2 hits.
    SSF55550. SSF55550. 1 hit.
    PROSITEi PS50001. SH2. 1 hit.
    PS50002. SH3. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Basal ganglia.

    Entry informationi

    Entry nameiGRAP_BOVIN
    AccessioniPrimary (citable) accession number: A6QLK6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 22, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3