Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

GRB2-related adapter protein

Gene

GRAP

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-BTA-1433557. Signaling by SCF-KIT.

Names & Taxonomyi

Protein namesi
Recommended name:
GRB2-related adapter protein
Gene namesi
Name:GRAP
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003442371 – 217GRB2-related adapter proteinAdd BLAST217

Proteomic databases

PaxDbiA6QLK6.

Expressioni

Gene expression databases

BgeeiENSBTAG00000003707.

Interactioni

Subunit structurei

Associates through its SH2 domain with ligand-activated receptors for stem cell factor (KIT) and erythropoietin (EPOR). Also forms a stable complex with the Bcr-Abl oncoprotein. GRAP is associated with the Ras guanine nucleotide exchange factor SOS1, primarily through its N-terminal SH3 domain. Interacts with phosphorylated LAT upon TCR activation. Interacts with SHB (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000041340.

Structurei

3D structure databases

ProteinModelPortaliA6QLK6.
SMRiA6QLK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 58SH3 1PROSITE-ProRule annotationAdd BLAST58
Domaini60 – 152SH2PROSITE-ProRule annotationAdd BLAST93
Domaini158 – 217SH3 2PROSITE-ProRule annotationAdd BLAST60

Sequence similaritiesi

Belongs to the GRB2/sem-5/DRK family.Curated

Keywords - Domaini

Repeat, SH2 domain, SH3 domain

Phylogenomic databases

eggNOGiKOG3601. Eukaryota.
ENOG410XR1G. LUCA.
GeneTreeiENSGT00820000126999.
HOGENOMiHOG000251625.
HOVERGENiHBG005404.
InParanoidiA6QLK6.
OMAiRACFAQA.
OrthoDBiEOG091G0HWS.
TreeFamiTF354288.

Family and domain databases

CDDicd11948. SH3_GRAP_N. 1 hit.
Gene3Di3.30.505.10. 1 hit.
InterProiView protein in InterPro
IPR035645. GRAP_N_SH3.
IPR000980. SH2.
IPR036860. SH2_dom_sf.
IPR036028. SH3-like_dom_sf.
IPR001452. SH3_domain.
PfamiView protein in Pfam
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
PF07653. SH3_2. 1 hit.
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTiView protein in SMART
SM00252. SH2. 1 hit.
SM00326. SH3. 2 hits.
SUPFAMiSSF50044. SSF50044. 2 hits.
SSF55550. SSF55550. 1 hit.
PROSITEiView protein in PROSITE
PS50001. SH2. 1 hit.
PS50002. SH3. 2 hits.

Sequencei

Sequence statusi: Complete.

A6QLK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESVALYSFQ ATESDELAFN KGDTLKILNM EDDQNWYKAE LRGAEGFVPK
60 70 80 90 100
NYIRLKPHPW YSGRISRQLA EEILMKRNHQ GAFLIRESES SPGEFSVSVN
110 120 130 140 150
YGDQVQHFKV LRDPSGKYYL WEEKFNSLNE LVAFYRTTTI AKKRQVFLQD
160 170 180 190 200
EEPLPKPPRA CFAQAQFDFS AQDPSQLSFR RGDIIEVLER LDPSWWRGRL
210
SGRIGFFPRS YVQPVHM
Length:217
Mass (Da):25,367
Last modified:August 21, 2007 - v1
Checksum:i11EEB0D6F7122D41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC147998 mRNA. Translation: AAI47999.1.
RefSeqiNP_001095643.1. NM_001102173.1.
XP_010814339.1. XM_010816037.2.
UniGeneiBt.20119.

Genome annotation databases

EnsembliENSBTAT00000043796; ENSBTAP00000041340; ENSBTAG00000003707.
GeneIDi534491.
KEGGibta:534491.

Similar proteinsi

Entry informationi

Entry nameiGRAP_BOVIN
AccessioniPrimary (citable) accession number: A6QLK6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: August 21, 2007
Last modified: November 22, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families