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A6QLK6 (GRAP_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GRB2-related adapter protein
Gene names
Name:GRAP
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length217 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway By similarity.

Subunit structure

Associates through its SH2 domain with ligand-activated receptors for stem cell factor (KIT) and erythropoietin (EPOR). Also forms a stable complex with the Bcr-Abl oncoprotein. GRAP is associated with the Ras guanine nucleotide exchange factor SOS1, primarily through its N-terminal SH3 domain. Interacts with phosphorylated LAT upon TCR activation. Interacts with SHB By similarity.

Sequence similarities

Belongs to the GRB2/sem-5/DRK family.

Contains 1 SH2 domain.

Contains 2 SH3 domains.

Ontologies

Keywords
   DomainRepeat
SH2 domain
SH3 domain
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 217217GRB2-related adapter protein
PRO_0000344237

Regions

Domain1 – 5858SH3 1
Domain60 – 15293SH2
Domain156 – 21560SH3 2

Sequences

Sequence LengthMass (Da)Tools
A6QLK6 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 11EEB0D6F7122D41

FASTA21725,367
        10         20         30         40         50         60 
MESVALYSFQ ATESDELAFN KGDTLKILNM EDDQNWYKAE LRGAEGFVPK NYIRLKPHPW 

        70         80         90        100        110        120 
YSGRISRQLA EEILMKRNHQ GAFLIRESES SPGEFSVSVN YGDQVQHFKV LRDPSGKYYL 

       130        140        150        160        170        180 
WEEKFNSLNE LVAFYRTTTI AKKRQVFLQD EEPLPKPPRA CFAQAQFDFS AQDPSQLSFR 

       190        200        210 
RGDIIEVLER LDPSWWRGRL SGRIGFFPRS YVQPVHM 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Basal ganglia.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC147998 mRNA. Translation: AAI47999.1.
RefSeqNP_001095643.1. NM_001102173.1.
UniGeneBt.20119.

3D structure databases

ProteinModelPortalA6QLK6.
SMRA6QLK6. Positions 1-158.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000041340.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000043796; ENSBTAP00000041340; ENSBTAG00000003707.
GeneID534491.
KEGGbta:534491.

Organism-specific databases

CTD10750.

Phylogenomic databases

eggNOGNOG298780.
GeneTreeENSGT00550000074482.
HOGENOMHOG000251625.
HOVERGENHBG005404.
InParanoidA6QLK6.
OMARACFAQA.
OrthoDBEOG75F4F6.
TreeFamTF354288.

Family and domain databases

Gene3D3.30.505.10. 1 hit.
InterProIPR000980. SH2.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamPF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTSM00252. SH2. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMSSF50044. SSF50044. 2 hits.
SSF55550. SSF55550. 1 hit.
PROSITEPS50001. SH2. 1 hit.
PS50002. SH3. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20876418.

Entry information

Entry nameGRAP_BOVIN
AccessionPrimary (citable) accession number: A6QLK6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: August 21, 2007
Last modified: April 16, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families