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Protein

Transmembrane protein 8B

Gene

TMEM8B

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processCell adhesion, Growth regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 8B
Alternative name(s):
Protein NGX6
Gene namesi
Name:TMEM8B
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 233ExtracellularSequence analysisAdd BLAST233
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Topological domaini255 – 257CytoplasmicSequence analysis3
Transmembranei258 – 277HelicalSequence analysisAdd BLAST20
Topological domaini278 – 292ExtracellularSequence analysisAdd BLAST15
Transmembranei293 – 313HelicalSequence analysisAdd BLAST21
Topological domaini314 – 315CytoplasmicSequence analysis2
Transmembranei316 – 336HelicalSequence analysisAdd BLAST21
Topological domaini337 – 342ExtracellularSequence analysis6
Transmembranei343 – 363HelicalSequence analysisAdd BLAST21
Topological domaini364 – 379CytoplasmicSequence analysisAdd BLAST16
Transmembranei380 – 400HelicalSequence analysisAdd BLAST21
Topological domaini401 – 405ExtracellularSequence analysis5
Transmembranei406 – 426HelicalSequence analysisAdd BLAST21
Topological domaini427 – 472CytoplasmicSequence analysisAdd BLAST46

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endoplasmic reticulum, Membrane, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003330381 – 472Transmembrane protein 8BAdd BLAST472

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi92N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi186 ↔ 196By similarity
Disulfide bondi190 ↔ 209By similarity
Disulfide bondi211 ↔ 220By similarity

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6QLK4
PRIDEiA6QLK4

Interactioni

Subunit structurei

May interact with EZR.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015212

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini182 – 221EGF-likeAdd BLAST40

Sequence similaritiesi

Belongs to the TMEM8 family.Curated

Keywords - Domaini

EGF-like domain, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHJ3 Eukaryota
ENOG4111FA8 LUCA
HOGENOMiHOG000049225
InParanoidiA6QLK4

Family and domain databases

InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR021910 NGX6/PGAP6/MYMK
PANTHERiPTHR14319 PTHR14319, 1 hit
PfamiView protein in Pfam
PF12036 DUF3522, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit

Sequencei

Sequence statusi: Complete.

A6QLK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNMPQSLGNQ PLPPEPPSLR TPAEGPGATS PPEHCWPVRP TLRNELDTFS
60 70 80 90 100
VHFYIFFGPS VALPPERPAV FALRLLPVLD SGGVLSLELQ LNVSSLRQEN
110 120 130 140 150
VTVFGCLTHE VPLSLGDAAV TCSKESLAGF LLTVSAASRV ARLRIPFPQT
160 170 180 190 200
GTWFLTLRSL CGVGPRFVRC RNATAEVRLR TFLSPCVDDC GPYGQCKLLR
210 220 230 240 250
THNYLYAACE CKAGWRGWGC TDSADALTYG FQLLSTLLLC LSNLMFLPPV
260 270 280 290 300
VLAIRSRYVL EAAVYTFTMF FSTFYHACDQ PGIVVFCIMD YDVLQFCDFL
310 320 330 340 350
GSLMSVWVTV IAMARLQPVV KQVLYLLGAM LLSMALQLDR HGLWNLLGPS
360 370 380 390 400
LFALGILATA WTVRSVRRRH CYPPTWRRWL FCLCPGSLIA GSAILLYAFV
410 420 430 440 450
ETRDNYFYIH SIWHMLIAGS VGFLLPPRAK TDRRVPSGAR ARGCGYQLCI
460 470
NEQEELGLVG PGGATVSSIC AS
Length:472
Mass (Da):52,088
Last modified:August 21, 2007 - v1
Checksum:iF38114D6D8B9DFE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC147996 mRNA Translation: AAI47997.1
BC149881 mRNA Translation: AAI49882.1
RefSeqiNP_001096805.1, NM_001103335.1
UniGeneiBt.31084

Genome annotation databases

GeneIDi100125302
KEGGibta:100125302

Similar proteinsi

Entry informationi

Entry nameiTMM8B_BOVIN
AccessioniPrimary (citable) accession number: A6QLK4
Secondary accession number(s): A6QQL1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 21, 2007
Last modified: December 20, 2017
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health