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A6QLI8 (T2EA_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
General transcription factor IIE subunit 1
Alternative name(s):
Transcription initiation factor IIE subunit alpha
Short name=TFIIE-alpha
Gene names
Name:GTF2E1
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length438 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase By similarity.

Subunit structure

Tetramer of two alpha and two beta chains. Interacts with TAF6/TAFII80 By similarity. Interacts with ATF7IP By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the TFIIE alpha subunit family.

Contains 1 HTH TFE/IIEalpha-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 438437General transcription factor IIE subunit 1
PRO_0000318949

Regions

Domain14 – 10491HTH TFE/IIEalpha-type
Zinc finger129 – 15729C4-type Potential
Compositional bias378 – 39215Asp/Glu-rich (acidic)

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue671N6-acetyllysine By similarity
Modified residue2681Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
A6QLI8 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: A0243821FC3FD720

FASTA43849,211
        10         20         30         40         50         60 
MADPDVLTEV PAALKRLAKY VIRGFYGIEH ALALDILIRN PCVKEEDMLE LLKFDRKQLR 

        70         80         90        100        110        120 
SVLNNLKGDK FIKCRMRVET AADGKTTRHN YYFINYRTLV NVVKYKLDHM RRRIETDERD 

       130        140        150        160        170        180 
STNRASFKCP VCSSTFTDLE ANQLFDPMTG TFRCTFCQTE VEEDESAMPK KDARTLLARF 

       190        200        210        220        230        240 
NEQIEPIYAL LRETEDVNLA YEILEPEPTE IPALKQSKDR AATAAGAAGL AGGHHREAWT 

       250        260        270        280        290        300 
TKGPSYEDLY TQNVVINMDD QEDLHRASLE GKSAKERPIW LRESTVQGAY NSEEMKEGGI 

       310        320        330        340        350        360 
DIDSFQEHEE GHAGPDDNEE VMRALLIHEK KTPSAPAGSV GAAAPVTAAN GSDSESETSE 

       370        380        390        400        410        420 
SDDDSPPRVA TVAAHHGEED EEDDEFEEVA DDPVVMVAGR PFSYSEVSQK PELVAQMTPE 

       430 
EKEAYIAMGQ RMFEDLFE 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Basal ganglia.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC147980 mRNA. Translation: AAI47981.1.
RefSeqNP_001096764.1. NM_001103294.1.
UniGeneBt.9665.

3D structure databases

ProteinModelPortalA6QLI8.
SMRA6QLI8. Positions 113-174, 393-438.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000050375.

Proteomic databases

PRIDEA6QLI8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID540525.
KEGGbta:540525.

Organism-specific databases

CTD2960.

Phylogenomic databases

eggNOGCOG1675.
HOGENOMHOG000007666.
HOVERGENHBG008614.
InParanoidA6QLI8.
KOK03136.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR017919. TFIIE/TFIIEa_HTH.
IPR002853. TFIIE_asu.
IPR021600. TFIIE_asu_C.
IPR024550. TFIIEa/SarR/Rpc3_HTH_dom.
IPR013083. Znf_RING/FYVE/PHD.
IPR013137. Znf_TFIIB.
[Graphical view]
PfamPF08271. TF_Zn_Ribbon. 1 hit.
PF11521. TFIIE-A_C-term. 1 hit.
PF02002. TFIIE_alpha. 1 hit.
[Graphical view]
SMARTSM00531. TFIIE. 1 hit.
[Graphical view]
PROSITEPS51344. HTH_TFE_IIE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20878682.

Entry information

Entry nameT2EA_BOVIN
AccessionPrimary (citable) accession number: A6QLI8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: August 21, 2007
Last modified: February 19, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families