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A6QLI8

- T2EA_BOVIN

UniProt

A6QLI8 - T2EA_BOVIN

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Protein

General transcription factor IIE subunit 1

Gene

GTF2E1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri129 – 15729C4-typeSequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription initiation from RNA polymerase II promoter Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor IIE subunit 1
Alternative name(s):
Transcription initiation factor IIE subunit alpha
Short name:
TFIIE-alpha
Gene namesi
Name:GTF2E1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 438437General transcription factor IIE subunit 1PRO_0000318949Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei67 – 671N6-acetyllysineBy similarity
Modified residuei268 – 2681PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiA6QLI8.

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains. Interacts with TAF6/TAFII80 (By similarity). Interacts with ATF7IP (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000050375.

Structurei

3D structure databases

ProteinModelPortaliA6QLI8.
SMRiA6QLI8. Positions 113-174, 393-438.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 10491HTH TFE/IIEalpha-typePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi378 – 39215Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Belongs to the TFIIE alpha subunit family.Curated
Contains 1 HTH TFE/IIEalpha-type domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri129 – 15729C4-typeSequence AnalysisAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG1675.
HOGENOMiHOG000007666.
HOVERGENiHBG008614.
InParanoidiA6QLI8.
KOiK03136.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR017919. TFIIE/TFIIEa_HTH.
IPR002853. TFIIE_asu.
IPR021600. TFIIE_asu_C.
IPR024550. TFIIEa/SarR/Rpc3_HTH_dom.
IPR013083. Znf_RING/FYVE/PHD.
IPR013137. Znf_TFIIB.
[Graphical view]
PfamiPF08271. TF_Zn_Ribbon. 1 hit.
PF11521. TFIIE-A_C-term. 1 hit.
PF02002. TFIIE_alpha. 1 hit.
[Graphical view]
SMARTiSM00531. TFIIE. 1 hit.
[Graphical view]
PROSITEiPS51344. HTH_TFE_IIE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6QLI8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADPDVLTEV PAALKRLAKY VIRGFYGIEH ALALDILIRN PCVKEEDMLE
60 70 80 90 100
LLKFDRKQLR SVLNNLKGDK FIKCRMRVET AADGKTTRHN YYFINYRTLV
110 120 130 140 150
NVVKYKLDHM RRRIETDERD STNRASFKCP VCSSTFTDLE ANQLFDPMTG
160 170 180 190 200
TFRCTFCQTE VEEDESAMPK KDARTLLARF NEQIEPIYAL LRETEDVNLA
210 220 230 240 250
YEILEPEPTE IPALKQSKDR AATAAGAAGL AGGHHREAWT TKGPSYEDLY
260 270 280 290 300
TQNVVINMDD QEDLHRASLE GKSAKERPIW LRESTVQGAY NSEEMKEGGI
310 320 330 340 350
DIDSFQEHEE GHAGPDDNEE VMRALLIHEK KTPSAPAGSV GAAAPVTAAN
360 370 380 390 400
GSDSESETSE SDDDSPPRVA TVAAHHGEED EEDDEFEEVA DDPVVMVAGR
410 420 430
PFSYSEVSQK PELVAQMTPE EKEAYIAMGQ RMFEDLFE
Length:438
Mass (Da):49,211
Last modified:August 21, 2007 - v1
Checksum:iA0243821FC3FD720
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC147980 mRNA. Translation: AAI47981.1.
RefSeqiNP_001096764.1. NM_001103294.1.
UniGeneiBt.9665.

Genome annotation databases

GeneIDi540525.
KEGGibta:540525.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC147980 mRNA. Translation: AAI47981.1 .
RefSeqi NP_001096764.1. NM_001103294.1.
UniGenei Bt.9665.

3D structure databases

ProteinModelPortali A6QLI8.
SMRi A6QLI8. Positions 113-174, 393-438.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000050375.

Proteomic databases

PRIDEi A6QLI8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 540525.
KEGGi bta:540525.

Organism-specific databases

CTDi 2960.

Phylogenomic databases

eggNOGi COG1675.
HOGENOMi HOG000007666.
HOVERGENi HBG008614.
InParanoidi A6QLI8.
KOi K03136.

Miscellaneous databases

NextBioi 20878682.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR017919. TFIIE/TFIIEa_HTH.
IPR002853. TFIIE_asu.
IPR021600. TFIIE_asu_C.
IPR024550. TFIIEa/SarR/Rpc3_HTH_dom.
IPR013083. Znf_RING/FYVE/PHD.
IPR013137. Znf_TFIIB.
[Graphical view ]
Pfami PF08271. TF_Zn_Ribbon. 1 hit.
PF11521. TFIIE-A_C-term. 1 hit.
PF02002. TFIIE_alpha. 1 hit.
[Graphical view ]
SMARTi SM00531. TFIIE. 1 hit.
[Graphical view ]
PROSITEi PS51344. HTH_TFE_IIE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Basal ganglia.

Entry informationi

Entry nameiT2EA_BOVIN
AccessioniPrimary (citable) accession number: A6QLI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: August 21, 2007
Last modified: October 29, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3