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A6QLI8

- T2EA_BOVIN

UniProt

A6QLI8 - T2EA_BOVIN

Protein

General transcription factor IIE subunit 1

Gene

GTF2E1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri129 – 15729C4-typeSequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. sequence-specific DNA binding Source: InterPro

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription initiation from RNA polymerase II promoter Source: InterPro

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    General transcription factor IIE subunit 1
    Alternative name(s):
    Transcription initiation factor IIE subunit alpha
    Short name:
    TFIIE-alpha
    Gene namesi
    Name:GTF2E1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 438437General transcription factor IIE subunit 1PRO_0000318949Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei67 – 671N6-acetyllysineBy similarity
    Modified residuei268 – 2681PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PRIDEiA6QLI8.

    Interactioni

    Subunit structurei

    Tetramer of two alpha and two beta chains. Interacts with TAF6/TAFII80 By similarity. Interacts with ATF7IP By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000050375.

    Structurei

    3D structure databases

    ProteinModelPortaliA6QLI8.
    SMRiA6QLI8. Positions 113-174, 393-438.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini14 – 10491HTH TFE/IIEalpha-typePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi378 – 39215Asp/Glu-rich (acidic)Add
    BLAST

    Sequence similaritiesi

    Belongs to the TFIIE alpha subunit family.Curated
    Contains 1 HTH TFE/IIEalpha-type domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri129 – 15729C4-typeSequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG1675.
    HOGENOMiHOG000007666.
    HOVERGENiHBG008614.
    InParanoidiA6QLI8.
    KOiK03136.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR017919. TFIIE/TFIIEa_HTH.
    IPR002853. TFIIE_asu.
    IPR021600. TFIIE_asu_C.
    IPR024550. TFIIEa/SarR/Rpc3_HTH_dom.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR013137. Znf_TFIIB.
    [Graphical view]
    PfamiPF08271. TF_Zn_Ribbon. 1 hit.
    PF11521. TFIIE-A_C-term. 1 hit.
    PF02002. TFIIE_alpha. 1 hit.
    [Graphical view]
    SMARTiSM00531. TFIIE. 1 hit.
    [Graphical view]
    PROSITEiPS51344. HTH_TFE_IIE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A6QLI8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADPDVLTEV PAALKRLAKY VIRGFYGIEH ALALDILIRN PCVKEEDMLE    50
    LLKFDRKQLR SVLNNLKGDK FIKCRMRVET AADGKTTRHN YYFINYRTLV 100
    NVVKYKLDHM RRRIETDERD STNRASFKCP VCSSTFTDLE ANQLFDPMTG 150
    TFRCTFCQTE VEEDESAMPK KDARTLLARF NEQIEPIYAL LRETEDVNLA 200
    YEILEPEPTE IPALKQSKDR AATAAGAAGL AGGHHREAWT TKGPSYEDLY 250
    TQNVVINMDD QEDLHRASLE GKSAKERPIW LRESTVQGAY NSEEMKEGGI 300
    DIDSFQEHEE GHAGPDDNEE VMRALLIHEK KTPSAPAGSV GAAAPVTAAN 350
    GSDSESETSE SDDDSPPRVA TVAAHHGEED EEDDEFEEVA DDPVVMVAGR 400
    PFSYSEVSQK PELVAQMTPE EKEAYIAMGQ RMFEDLFE 438
    Length:438
    Mass (Da):49,211
    Last modified:August 21, 2007 - v1
    Checksum:iA0243821FC3FD720
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC147980 mRNA. Translation: AAI47981.1.
    RefSeqiNP_001096764.1. NM_001103294.1.
    UniGeneiBt.9665.

    Genome annotation databases

    GeneIDi540525.
    KEGGibta:540525.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC147980 mRNA. Translation: AAI47981.1 .
    RefSeqi NP_001096764.1. NM_001103294.1.
    UniGenei Bt.9665.

    3D structure databases

    ProteinModelPortali A6QLI8.
    SMRi A6QLI8. Positions 113-174, 393-438.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000050375.

    Proteomic databases

    PRIDEi A6QLI8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 540525.
    KEGGi bta:540525.

    Organism-specific databases

    CTDi 2960.

    Phylogenomic databases

    eggNOGi COG1675.
    HOGENOMi HOG000007666.
    HOVERGENi HBG008614.
    InParanoidi A6QLI8.
    KOi K03136.

    Miscellaneous databases

    NextBioi 20878682.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR017919. TFIIE/TFIIEa_HTH.
    IPR002853. TFIIE_asu.
    IPR021600. TFIIE_asu_C.
    IPR024550. TFIIEa/SarR/Rpc3_HTH_dom.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR013137. Znf_TFIIB.
    [Graphical view ]
    Pfami PF08271. TF_Zn_Ribbon. 1 hit.
    PF11521. TFIIE-A_C-term. 1 hit.
    PF02002. TFIIE_alpha. 1 hit.
    [Graphical view ]
    SMARTi SM00531. TFIIE. 1 hit.
    [Graphical view ]
    PROSITEi PS51344. HTH_TFE_IIE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Basal ganglia.

    Entry informationi

    Entry nameiT2EA_BOVIN
    AccessioniPrimary (citable) accession number: A6QLI8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3