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Protein

5-aminolevulinate synthase, nonspecific, mitochondrial

Gene

ALAS1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

Cofactori

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei224 – 2241SubstrateBy similarity
Binding sitei341 – 3411SubstrateBy similarity
Binding sitei360 – 3601SubstrateBy similarity
Binding sitei393 – 3931Pyridoxal phosphateBy similarity
Binding sitei421 – 4211Pyridoxal phosphateBy similarity
Binding sitei449 – 4491Pyridoxal phosphateBy similarity
Active sitei452 – 4521By similarity
Binding sitei481 – 4811Pyridoxal phosphateBy similarity
Binding sitei482 – 4821Pyridoxal phosphateBy similarity
Binding sitei569 – 5691SubstrateBy similarity

GO - Molecular functioni

  1. 5-aminolevulinate synthase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Heme biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

ReactomeiREACT_207237. PPARA activates gene expression.
REACT_212036. Heme biosynthesis.
REACT_214581. Transcriptional activation of mitochondrial biogenesis.
UniPathwayiUPA00251; UER00375.

Names & Taxonomyi

Protein namesi
Recommended name:
5-aminolevulinate synthase, nonspecific, mitochondrial (EC:2.3.1.37)
Short name:
ALAS-H
Alternative name(s):
5-aminolevulinic acid synthase 1
Delta-ALA synthase 1
Delta-aminolevulinate synthase 1
Gene namesi
Name:ALAS1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 22

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
  2. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 5656MitochondrionBy similarityAdd
BLAST
Chaini57 – 6475915-aminolevulinate synthase, nonspecific, mitochondrialPRO_0000352676Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei452 – 4521N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

PRIDEiA6QLI6.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005380.

Structurei

3D structure databases

ProteinModelPortaliA6QLI6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0156.
GeneTreeiENSGT00530000063111.
HOGENOMiHOG000221020.
HOVERGENiHBG005954.
InParanoidiA6QLI6.
KOiK00643.
OMAiPQMMSYF.
OrthoDBiEOG7TQV0F.
TreeFamiTF300724.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR015118. 5aminolev_synth_preseq.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
PF09029. Preseq_ALAS. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6QLI6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
METVVRRCPF LSRVPQAFLQ KAGKSLLFYA QNCPKMMEIG AKPAPRALST
60 70 80 90 100
SAVLCQQVTE TPPANEKDKA AKAEVQQAPD GSQQAPDGSQ QTADGTQLPS
110 120 130 140 150
GHPSLASSQG TGSKCPFLAA EMSQGGSSVF RKASLALQED VQEMHAVREE
160 170 180 190 200
VAQTSVNPSV INVKTEGGEL NGLLKNFQDI MRKQRPERVS HLLQDNLPKS
210 220 230 240 250
VCTFQYDRFF EKKIDEKKND HSYRVFKTVN RKAQCFPMAD DYSDSLISKK
260 270 280 290 300
QVSVWCSNDY LGMSRHPRVC GAVIDTLKQH GTGAGGTRNI SGTSKFHVDL
310 320 330 340 350
EQELADLHGK DAALLFSSCF VANDSTLFTL AKMMPGCEIY SDAGNHASMI
360 370 380 390 400
QGIRNSGVPK YIFRHNDVSH LRELLQRSDP AVPKIVAFET VHSMDGAVCP
410 420 430 440 450
LEELCDVAHE FGAITFVDEV HAVGLYGLQG GGIGDRDGVM PKMDIISGTL
460 470 480 490 500
GKAIGCVGGY IASTSSLIDT VRSYAAGFIF TTSLPPMLLA GALESVRILR
510 520 530 540 550
STEGRTLRRQ HQRNVKLMRQ MLMDAGLPVV HCPSHIIPVR VADAAKNTEV
560 570 580 590 600
CDELMTRHNI YVQAINYPTV PRGEELLRIA PTPHHTPQMM SYFVDNLLAT
610 620 630 640
WKRVGLELKP HSSAECNFCR RPLHFEMMSE REKSYFSGMS KLVSAQA
Length:647
Mass (Da):71,062
Last modified:August 21, 2007 - v1
Checksum:iDF0A4622352C9401
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC147978 mRNA. Translation: AAI47979.1.
RefSeqiNP_001094624.1. NM_001101154.1.
UniGeneiBt.15857.

Genome annotation databases

EnsembliENSBTAT00000005380; ENSBTAP00000005380; ENSBTAG00000004118.
GeneIDi534286.
KEGGibta:534286.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC147978 mRNA. Translation: AAI47979.1.
RefSeqiNP_001094624.1. NM_001101154.1.
UniGeneiBt.15857.

3D structure databases

ProteinModelPortaliA6QLI6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005380.

Proteomic databases

PRIDEiA6QLI6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000005380; ENSBTAP00000005380; ENSBTAG00000004118.
GeneIDi534286.
KEGGibta:534286.

Organism-specific databases

CTDi211.

Phylogenomic databases

eggNOGiCOG0156.
GeneTreeiENSGT00530000063111.
HOGENOMiHOG000221020.
HOVERGENiHBG005954.
InParanoidiA6QLI6.
KOiK00643.
OMAiPQMMSYF.
OrthoDBiEOG7TQV0F.
TreeFamiTF300724.

Enzyme and pathway databases

UniPathwayiUPA00251; UER00375.
ReactomeiREACT_207237. PPARA activates gene expression.
REACT_212036. Heme biosynthesis.
REACT_214581. Transcriptional activation of mitochondrial biogenesis.

Miscellaneous databases

NextBioi20876339.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR015118. 5aminolev_synth_preseq.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
PF09029. Preseq_ALAS. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Brain cortex.

Entry informationi

Entry nameiHEM1_BOVIN
AccessioniPrimary (citable) accession number: A6QLI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: August 21, 2007
Last modified: January 7, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two delta-ALA synthases in vertebrates: an erythroid- specific form and one (housekeeping) which is expressed in all tissues.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.