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A6QLI6

- HEM1_BOVIN

UniProt

A6QLI6 - HEM1_BOVIN

Protein

5-aminolevulinate synthase, nonspecific, mitochondrial

Gene

ALAS1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei224 – 2241SubstrateBy similarity
    Binding sitei341 – 3411SubstrateBy similarity
    Binding sitei360 – 3601SubstrateBy similarity
    Binding sitei393 – 3931Pyridoxal phosphateBy similarity
    Binding sitei421 – 4211Pyridoxal phosphateBy similarity
    Binding sitei449 – 4491Pyridoxal phosphateBy similarity
    Active sitei452 – 4521By similarity
    Binding sitei481 – 4811Pyridoxal phosphateBy similarity
    Binding sitei482 – 4821Pyridoxal phosphateBy similarity
    Binding sitei569 – 5691SubstrateBy similarity

    GO - Molecular functioni

    1. 5-aminolevulinate synthase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Heme biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    ReactomeiREACT_207237. PPARA activates gene expression.
    REACT_212036. Heme biosynthesis.
    REACT_214581. Transcriptional activation of mitochondrial biogenesis.
    UniPathwayiUPA00251; UER00375.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-aminolevulinate synthase, nonspecific, mitochondrial (EC:2.3.1.37)
    Short name:
    ALAS-H
    Alternative name(s):
    5-aminolevulinic acid synthase 1
    Delta-ALA synthase 1
    Delta-aminolevulinate synthase 1
    Gene namesi
    Name:ALAS1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 22

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell
    2. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 5656MitochondrionBy similarityAdd
    BLAST
    Chaini57 – 6475915-aminolevulinate synthase, nonspecific, mitochondrialPRO_0000352676Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei452 – 4521N6-(pyridoxal phosphate)lysineBy similarity

    Proteomic databases

    PRIDEiA6QLI6.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000005380.

    Structurei

    3D structure databases

    ProteinModelPortaliA6QLI6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0156.
    GeneTreeiENSGT00530000063111.
    HOGENOMiHOG000221020.
    HOVERGENiHBG005954.
    InParanoidiA6QLI6.
    KOiK00643.
    OMAiPQMMSYF.
    OrthoDBiEOG7TQV0F.
    TreeFamiTF300724.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
    IPR015118. 5aminolev_synth_preseq.
    IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    PF09029. Preseq_ALAS. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
    PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A6QLI6-1 [UniParc]FASTAAdd to Basket

    « Hide

    METVVRRCPF LSRVPQAFLQ KAGKSLLFYA QNCPKMMEIG AKPAPRALST    50
    SAVLCQQVTE TPPANEKDKA AKAEVQQAPD GSQQAPDGSQ QTADGTQLPS 100
    GHPSLASSQG TGSKCPFLAA EMSQGGSSVF RKASLALQED VQEMHAVREE 150
    VAQTSVNPSV INVKTEGGEL NGLLKNFQDI MRKQRPERVS HLLQDNLPKS 200
    VCTFQYDRFF EKKIDEKKND HSYRVFKTVN RKAQCFPMAD DYSDSLISKK 250
    QVSVWCSNDY LGMSRHPRVC GAVIDTLKQH GTGAGGTRNI SGTSKFHVDL 300
    EQELADLHGK DAALLFSSCF VANDSTLFTL AKMMPGCEIY SDAGNHASMI 350
    QGIRNSGVPK YIFRHNDVSH LRELLQRSDP AVPKIVAFET VHSMDGAVCP 400
    LEELCDVAHE FGAITFVDEV HAVGLYGLQG GGIGDRDGVM PKMDIISGTL 450
    GKAIGCVGGY IASTSSLIDT VRSYAAGFIF TTSLPPMLLA GALESVRILR 500
    STEGRTLRRQ HQRNVKLMRQ MLMDAGLPVV HCPSHIIPVR VADAAKNTEV 550
    CDELMTRHNI YVQAINYPTV PRGEELLRIA PTPHHTPQMM SYFVDNLLAT 600
    WKRVGLELKP HSSAECNFCR RPLHFEMMSE REKSYFSGMS KLVSAQA 647
    Length:647
    Mass (Da):71,062
    Last modified:August 21, 2007 - v1
    Checksum:iDF0A4622352C9401
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC147978 mRNA. Translation: AAI47979.1.
    RefSeqiNP_001094624.1. NM_001101154.1.
    UniGeneiBt.15857.

    Genome annotation databases

    EnsembliENSBTAT00000005380; ENSBTAP00000005380; ENSBTAG00000004118.
    GeneIDi534286.
    KEGGibta:534286.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC147978 mRNA. Translation: AAI47979.1 .
    RefSeqi NP_001094624.1. NM_001101154.1.
    UniGenei Bt.15857.

    3D structure databases

    ProteinModelPortali A6QLI6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000005380.

    Proteomic databases

    PRIDEi A6QLI6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000005380 ; ENSBTAP00000005380 ; ENSBTAG00000004118 .
    GeneIDi 534286.
    KEGGi bta:534286.

    Organism-specific databases

    CTDi 211.

    Phylogenomic databases

    eggNOGi COG0156.
    GeneTreei ENSGT00530000063111.
    HOGENOMi HOG000221020.
    HOVERGENi HBG005954.
    InParanoidi A6QLI6.
    KOi K00643.
    OMAi PQMMSYF.
    OrthoDBi EOG7TQV0F.
    TreeFami TF300724.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00375 .
    Reactomei REACT_207237. PPARA activates gene expression.
    REACT_212036. Heme biosynthesis.
    REACT_214581. Transcriptional activation of mitochondrial biogenesis.

    Miscellaneous databases

    NextBioi 20876339.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR010961. 4pyrrol_synth_NH2levulA_synth.
    IPR015118. 5aminolev_synth_preseq.
    IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    PF09029. Preseq_ALAS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01821. 5aminolev_synth. 1 hit.
    PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Brain cortex.

    Entry informationi

    Entry nameiHEM1_BOVIN
    AccessioniPrimary (citable) accession number: A6QLI6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 14, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    There are two delta-ALA synthases in vertebrates: an erythroid- specific form and one (housekeeping) which is expressed in all tissues.By similarity

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3