SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A6QLI6

- HEM1_BOVIN

UniProt

A6QLI6 - HEM1_BOVIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
5-aminolevulinate synthase, nonspecific, mitochondrial
Gene
ALAS1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

Cofactori

Pyridoxal phosphate By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei224 – 2241Substrate By similarity
Binding sitei341 – 3411Substrate By similarity
Binding sitei360 – 3601Substrate By similarity
Binding sitei393 – 3931Pyridoxal phosphate By similarity
Binding sitei421 – 4211Pyridoxal phosphate By similarity
Binding sitei449 – 4491Pyridoxal phosphate By similarity
Active sitei452 – 4521 By similarity
Binding sitei481 – 4811Pyridoxal phosphate By similarity
Binding sitei482 – 4821Pyridoxal phosphate By similarity
Binding sitei569 – 5691Substrate By similarity

GO - Molecular functioni

  1. 5-aminolevulinate synthase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Heme biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

ReactomeiREACT_207237. PPARA activates gene expression.
REACT_212036. Heme biosynthesis.
REACT_214581. Transcriptional activation of mitochondrial biogenesis.
UniPathwayiUPA00251; UER00375.

Names & Taxonomyi

Protein namesi
Recommended name:
5-aminolevulinate synthase, nonspecific, mitochondrial (EC:2.3.1.37)
Short name:
ALAS-H
Alternative name(s):
5-aminolevulinic acid synthase 1
Delta-ALA synthase 1
Delta-aminolevulinate synthase 1
Gene namesi
Name:ALAS1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 22

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
  2. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 5656Mitochondrion By similarity
Add
BLAST
Chaini57 – 6475915-aminolevulinate synthase, nonspecific, mitochondrial
PRO_0000352676Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei452 – 4521N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PRIDEiA6QLI6.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005380.

Structurei

3D structure databases

ProteinModelPortaliA6QLI6.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0156.
GeneTreeiENSGT00530000063111.
HOGENOMiHOG000221020.
HOVERGENiHBG005954.
InParanoidiA6QLI6.
KOiK00643.
OMAiPQMMSYF.
OrthoDBiEOG7TQV0F.
TreeFamiTF300724.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR015118. 5aminolev_synth_preseq.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
PF09029. Preseq_ALAS. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6QLI6-1 [UniParc]FASTAAdd to Basket

« Hide

METVVRRCPF LSRVPQAFLQ KAGKSLLFYA QNCPKMMEIG AKPAPRALST    50
SAVLCQQVTE TPPANEKDKA AKAEVQQAPD GSQQAPDGSQ QTADGTQLPS 100
GHPSLASSQG TGSKCPFLAA EMSQGGSSVF RKASLALQED VQEMHAVREE 150
VAQTSVNPSV INVKTEGGEL NGLLKNFQDI MRKQRPERVS HLLQDNLPKS 200
VCTFQYDRFF EKKIDEKKND HSYRVFKTVN RKAQCFPMAD DYSDSLISKK 250
QVSVWCSNDY LGMSRHPRVC GAVIDTLKQH GTGAGGTRNI SGTSKFHVDL 300
EQELADLHGK DAALLFSSCF VANDSTLFTL AKMMPGCEIY SDAGNHASMI 350
QGIRNSGVPK YIFRHNDVSH LRELLQRSDP AVPKIVAFET VHSMDGAVCP 400
LEELCDVAHE FGAITFVDEV HAVGLYGLQG GGIGDRDGVM PKMDIISGTL 450
GKAIGCVGGY IASTSSLIDT VRSYAAGFIF TTSLPPMLLA GALESVRILR 500
STEGRTLRRQ HQRNVKLMRQ MLMDAGLPVV HCPSHIIPVR VADAAKNTEV 550
CDELMTRHNI YVQAINYPTV PRGEELLRIA PTPHHTPQMM SYFVDNLLAT 600
WKRVGLELKP HSSAECNFCR RPLHFEMMSE REKSYFSGMS KLVSAQA 647
Length:647
Mass (Da):71,062
Last modified:August 21, 2007 - v1
Checksum:iDF0A4622352C9401
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC147978 mRNA. Translation: AAI47979.1.
RefSeqiNP_001094624.1. NM_001101154.1.
UniGeneiBt.15857.

Genome annotation databases

EnsembliENSBTAT00000005380; ENSBTAP00000005380; ENSBTAG00000004118.
GeneIDi534286.
KEGGibta:534286.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC147978 mRNA. Translation: AAI47979.1 .
RefSeqi NP_001094624.1. NM_001101154.1.
UniGenei Bt.15857.

3D structure databases

ProteinModelPortali A6QLI6.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000005380.

Proteomic databases

PRIDEi A6QLI6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000005380 ; ENSBTAP00000005380 ; ENSBTAG00000004118 .
GeneIDi 534286.
KEGGi bta:534286.

Organism-specific databases

CTDi 211.

Phylogenomic databases

eggNOGi COG0156.
GeneTreei ENSGT00530000063111.
HOGENOMi HOG000221020.
HOVERGENi HBG005954.
InParanoidi A6QLI6.
KOi K00643.
OMAi PQMMSYF.
OrthoDBi EOG7TQV0F.
TreeFami TF300724.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00375 .
Reactomei REACT_207237. PPARA activates gene expression.
REACT_212036. Heme biosynthesis.
REACT_214581. Transcriptional activation of mitochondrial biogenesis.

Miscellaneous databases

NextBioi 20876339.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR015118. 5aminolev_synth_preseq.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF00155. Aminotran_1_2. 1 hit.
PF09029. Preseq_ALAS. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01821. 5aminolev_synth. 1 hit.
PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Brain cortex.

Entry informationi

Entry nameiHEM1_BOVIN
AccessioniPrimary (citable) accession number: A6QLI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: August 21, 2007
Last modified: September 3, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two delta-ALA synthases in vertebrates: an erythroid- specific form and one (housekeeping) which is expressed in all tissues By similarity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi