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Protein

Secretogranin-3

Gene

SCG3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-BTA-114608. Platelet degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Secretogranin-3
Alternative name(s):
Secretogranin III
Short name:
SgIII
Gene namesi
Name:SCG3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componentsi: Chromosome 10, Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 471449Secretogranin-3PRO_0000417022Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei40 – 401PhosphoserineBy similarity
Glycosylationi71 – 711N-linked (GlcNAc...)Sequence analysis
Glycosylationi353 – 3531N-linked (GlcNAc...)Sequence analysis
Modified residuei365 – 3651PhosphoserineBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiA6QLI2.

Interactioni

Subunit structurei

Interacts with CHGA.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000023512.

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHUH. Eukaryota.
ENOG4110KQ3. LUCA.
GeneTreeiENSGT00390000005488.
HOGENOMiHOG000247064.
HOVERGENiHBG057085.
InParanoidiA6QLI2.
OMAiANNYEED.
OrthoDBiEOG7G1V64.
TreeFamiTF331266.

Family and domain databases

InterProiIPR026197. SCG3.
[Graphical view]
PANTHERiPTHR17388. PTHR17388. 1 hit.
PfamiPF15467. SGIII. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6QLI2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFLWTGTWI VVLMLHSSPI QAFPKPAGSQ DKPLHNRELS AERPLNEQIA
60 70 80 90 100
EAEADEIKKT YPPENKPGES NYSFVDNLNL LKAITEKEKN EKERQSVKIS
110 120 130 140 150
PNDNKLNVED VDSTKNRRLI DDYDSTKSGL DRKFQDDPDG LHQLDGTPLT
160 170 180 190 200
AEDIVQKIAT RIYEENDRGV FDRIVSKLLN LGLITESQAH TLEDEVAEVL
210 220 230 240 250
QKLISKEANN YEEELNKPTS KTESQTGKIP EKVTPMAAIQ DAFTNGENDE
260 270 280 290 300
TVSNTLTLTN GLERRTKTYS EDNFEELQYF PNFYALLKSI DSEKEAKEKE
310 320 330 340 350
TLITIMKTLI DFVKMMVKYG TISPEEGVSY LENLDETIAL QTKNKLEKNV
360 370 380 390 400
TDNKSKLFAV PSEKSHEETD STKEEAAKME KEYGTLKDST KDDDSNPRGK
410 420 430 440 450
TDEHKGKTEA YLEAIRKNID WLKKHNKKEN KEDYDLSKMR DFINQQADAY
460 470
VEKGILDKEE ADAIKRIYSS L
Length:471
Mass (Da):53,751
Last modified:August 21, 2007 - v1
Checksum:i267A1E8AA89E70F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02029009 Genomic DNA. No translation available.
DAAA02029010 Genomic DNA. No translation available.
DAAA02029011 Genomic DNA. No translation available.
BC147974 mRNA. Translation: AAI47975.1.
RefSeqiNP_001095567.1. NM_001102097.1.
UniGeneiBt.42407.

Genome annotation databases

EnsembliENSBTAT00000023512; ENSBTAP00000023512; ENSBTAG00000017677.
GeneIDi525941.
KEGGibta:525941.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02029009 Genomic DNA. No translation available.
DAAA02029010 Genomic DNA. No translation available.
DAAA02029011 Genomic DNA. No translation available.
BC147974 mRNA. Translation: AAI47975.1.
RefSeqiNP_001095567.1. NM_001102097.1.
UniGeneiBt.42407.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000023512.

Proteomic databases

PaxDbiA6QLI2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000023512; ENSBTAP00000023512; ENSBTAG00000017677.
GeneIDi525941.
KEGGibta:525941.

Organism-specific databases

CTDi29106.

Phylogenomic databases

eggNOGiENOG410IHUH. Eukaryota.
ENOG4110KQ3. LUCA.
GeneTreeiENSGT00390000005488.
HOGENOMiHOG000247064.
HOVERGENiHBG057085.
InParanoidiA6QLI2.
OMAiANNYEED.
OrthoDBiEOG7G1V64.
TreeFamiTF331266.

Enzyme and pathway databases

ReactomeiR-BTA-114608. Platelet degranulation.

Family and domain databases

InterProiIPR026197. SCG3.
[Graphical view]
PANTHERiPTHR17388. PTHR17388. 1 hit.
PfamiPF15467. SGIII. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hereford.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Brain cortex.

Entry informationi

Entry nameiSCG3_BOVIN
AccessioniPrimary (citable) accession number: A6QLI2
Secondary accession number(s): F1MY56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2012
Last sequence update: August 21, 2007
Last modified: June 8, 2016
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.