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Protein

N-terminal kinase-like protein

Gene

SCYL1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum. Involved in the maintenance of the Golgi apparatus morphology. Has no detectable kinase activity in vitro.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
N-terminal kinase-like protein
Alternative name(s):
SCY1-like protein 1
Gene namesi
Name:SCYL1
Synonyms:NTKL
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 807807N-terminal kinase-like proteinPRO_0000327441Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei753 – 7531PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA6QLH6.
PRIDEiA6QLH6.

Interactioni

Subunit structurei

Homooligomer. Interacts with GORAB. Interacts with COPA, COPB1 and COPB2. Interacts with AP2B1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000042855.

Structurei

3D structure databases

ProteinModelPortaliA6QLH6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 314301Protein kinasePROSITE-ProRule annotationAdd
BLAST
Repeati350 – 38839HEAT 1Add
BLAST
Repeati389 – 42739HEAT 2Add
BLAST
Repeati507 – 54539HEAT 3Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni792 – 80716Interacts with COPB1By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili760 – 79637Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi589 – 61931Pro-richAdd
BLAST

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Belongs to the protein kinase superfamily.Curated
Contains 3 HEAT repeats.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1243. Eukaryota.
ENOG410XQTG. LUCA.
HOGENOMiHOG000208340.
HOVERGENiHBG082065.
InParanoidiA6QLH6.
KOiK08876.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6QLH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWFFARDPVR DFPFELSPEP PEGSPPGPWV LHRGRKKATG SPVSIFVYDV
60 70 80 90 100
KPVAEEQTQV AKAAFKRLKT LRHPNILAYI DGLETDKCLH VVTEAVTPLG
110 120 130 140 150
VYLKARAEAG GLKELELSWG LHQIVKALSF LVNDCSLIHN NVCMAAVFVD
160 170 180 190 200
RAGEWKLGGL DYMYSAQGNG GGPPRKGIPE LEQYDPPELA DGSGRAVREK
210 220 230 240 250
WSADMWRLGC LIWEVFNGPL PRAAALRNPG KIPKSLVPHY CELVGANPKV
260 270 280 290 300
RPNPARFLQN CRAPGGFMNN RFVETNLFLE EIQIKEPAEK QKFFQELSKS
310 320 330 340 350
LDSFPEDFCR HKVLPQLLTA FEFGSAGAVV LTPLFKVGKF LNAEEYQQKI
360 370 380 390 400
IPVVVKMFSS TDRAMRIRLL QQMEQFIQYL DEPTVNTQIF PHVVHGFLDT
410 420 430 440 450
NPAIREQTVK SMLLLAPKLN ETNLNVELMK HFARLQAKDE QGPIRCNTTV
460 470 480 490 500
CLGKIGSYLS ASTRHRVLTS AFSRATKDPF APSRVAGVLG FAATHNLYSM
510 520 530 540 550
NDCAHKILPV LCGLTVDPEK SVRDQAFKAI RSFLSKLESV SEDPTQLAEV
560 570 580 590 600
EKDVHAASSP GMGGAAASWA GWAVTGVSSL TSKLIRAHPT AALAETNVPQ
610 620 630 640 650
RPAPEGLPAP APTPVPATPT TSGPWETQEE SKDTEEDSSA ADRWDDEDWG
660 670 680 690 700
SLEQEAESVL AQRDDWSTGN QASRAGQASN PGHRSQESDW SSWEAEGSWE
710 720 730 740 750
QDWQEPSPPA PPPEGTRLAS EYNWGGPEPS DKGYPFAALS VHREAGAQSR
760 770 780 790 800
RDSWGDDNWE GLETESRQAK AELARKKREE RRREMEAKRA EKKAAKGPMK

LGTRKLD
Length:807
Mass (Da):89,325
Last modified:August 21, 2007 - v1
Checksum:i7A6091F1EB6D4C1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC147968 mRNA. Translation: AAI47969.1.
RefSeqiNP_001095491.1. NM_001102021.2.
UniGeneiBt.91117.

Genome annotation databases

GeneIDi515247.
KEGGibta:515247.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC147968 mRNA. Translation: AAI47969.1.
RefSeqiNP_001095491.1. NM_001102021.2.
UniGeneiBt.91117.

3D structure databases

ProteinModelPortaliA6QLH6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000042855.

Proteomic databases

PaxDbiA6QLH6.
PRIDEiA6QLH6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi515247.
KEGGibta:515247.

Organism-specific databases

CTDi57410.

Phylogenomic databases

eggNOGiKOG1243. Eukaryota.
ENOG410XQTG. LUCA.
HOGENOMiHOG000208340.
HOVERGENiHBG082065.
InParanoidiA6QLH6.
KOiK08876.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCYL1_BOVIN
AccessioniPrimary (citable) accession number: A6QLH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: August 21, 2007
Last modified: September 7, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.