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A6QLB8

- A6QLB8_BOVIN

UniProt

A6QLB8 - A6QLB8_BOVIN

Protein
Submitted name:

GSK3A protein

Gene

GSK3A

Organism
Bos taurus (Bovine)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: Ensembl

    GO - Biological processi

    1. cardiac left ventricle morphogenesis Source: Ensembl
    2. cell migration Source: Ensembl
    3. cellular response to lithium ion Source: Ensembl
    4. cellular response to organic cyclic compound Source: Ensembl
    5. hypermethylation of CpG island Source: Ensembl
    6. insulin receptor signaling pathway Source: Ensembl
    7. negative regulation of cell growth involved in cardiac muscle cell development Source: Ensembl
    8. negative regulation of TOR signaling Source: Ensembl
    9. positive regulation of adrenergic receptor signaling pathway Source: Ensembl
    10. positive regulation of cAMP biosynthetic process Source: Ensembl
    11. positive regulation of glycogen (starch) synthase activity Source: Ensembl
    12. positive regulation of heart contraction Source: Ensembl
    13. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
    14. positive regulation of peptidyl-threonine phosphorylation Source: Ensembl
    15. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    16. regulation of gene expression by genetic imprinting Source: Ensembl
    17. regulation of systemic arterial blood pressure Source: Ensembl

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_211201. XBP1(S) activates chaperone genes.
    REACT_215895. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_222898. AKT phosphorylates targets in the cytosol.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    GSK3A proteinImported
    Submitted name:
    Uncharacterized proteinImported
    Gene namesi
    Name:GSK3AImported
    OrganismiBos taurus (Bovine)Imported
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 18

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000027660.

    Structurei

    3D structure databases

    ProteinModelPortaliA6QLB8.
    SMRiA6QLB8. Positions 99-446.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00520000055635.
    HOGENOMiHOG000233017.
    HOVERGENiHBG014652.
    InParanoidiA6QLB8.
    KOiK08822.
    OMAiFDELRCP.
    OrthoDBiEOG7TF78V.
    TreeFamiTF101104.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6QLB8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGGAPSGGG PGGSGRARTS SFAEPGGGGG GGGGGPGGSA SGPGGSGGGK    50
    TSVGAMGGGV GASSSGGGPG GSGGGGSGGP GAGTSFPPPG VKLGRDSGKV 100
    TTVVATLGQG PERSQEVAYT DIKVIGSGSF GVVYQARLAD TRELVAIKKV 150
    LQDKRFKNRE LQIMRKLDHC NIVRLRYFFY SSGEKKDELY LNLVLEYVPE 200
    TVYRVARHFT KAKLSIPIIY VKVYMYQLFR SLAYIHSQGV CHRDIKPQNL 250
    LVDPDTAVLK LCDFGSAKQL VRGEPNVSYI CSRYYRAPEL IFGATDYTSS 300
    IDVWSAGCVL AELLLGQPIF PGDSGVDQLV EIIKVLGTPS REQIREMNPN 350
    YTEFKFPQIK AHPWTKVFKS RTPPEAIALC SSLLEYTPSS RLSPLEACAH 400
    SFFDELRCPG TQLPNNRPLP PLFNFSPGEL TIQPSLNAIL IPPHLRSPAG 450
    TASLTPSSQA LSEAQTSSDW QSTDNTATLP PGLHLLQPPH LLCPL 495
    Length:495
    Mass (Da):52,263
    Last modified:August 21, 2007 - v1
    Checksum:iDC13D3A3922F51C8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DAAA02047214 Genomic DNA. No translation available.
    DAAA02047215 Genomic DNA. No translation available.
    BC147908 mRNA. Translation: AAI47909.1.
    RefSeqiNP_001095662.1. NM_001102192.1.
    UniGeneiBt.33944.

    Genome annotation databases

    EnsembliENSBTAT00000027660; ENSBTAP00000027660; ENSBTAG00000020756.
    GeneIDi536561.
    KEGGibta:536561.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DAAA02047214 Genomic DNA. No translation available.
    DAAA02047215 Genomic DNA. No translation available.
    BC147908 mRNA. Translation: AAI47909.1 .
    RefSeqi NP_001095662.1. NM_001102192.1.
    UniGenei Bt.33944.

    3D structure databases

    ProteinModelPortali A6QLB8.
    SMRi A6QLB8. Positions 99-446.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000027660.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000027660 ; ENSBTAP00000027660 ; ENSBTAG00000020756 .
    GeneIDi 536561.
    KEGGi bta:536561.

    Organism-specific databases

    CTDi 2931.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00520000055635.
    HOGENOMi HOG000233017.
    HOVERGENi HBG014652.
    InParanoidi A6QLB8.
    KOi K08822.
    OMAi FDELRCP.
    OrthoDBi EOG7TF78V.
    TreeFami TF101104.

    Enzyme and pathway databases

    Reactomei REACT_211201. XBP1(S) activates chaperone genes.
    REACT_215895. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_222898. AKT phosphorylates targets in the cytosol.

    Miscellaneous databases

    NextBioi 20876974.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: L1 HerefordImported.
      Tissue: UterusImported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HerefordImported.
    3. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: HerefordImported.

    Entry informationi

    Entry nameiA6QLB8_BOVIN
    AccessioniPrimary (citable) accession number: A6QLB8
    Secondary accession number(s): F1MHW8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 21, 2007
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3