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Protein
Submitted name:

GSK3A protein

Gene

GSK3A

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: Ensembl

GO - Biological processi

  1. cardiac left ventricle morphogenesis Source: Ensembl
  2. cell migration Source: Ensembl
  3. cellular response to interleukin-3 Source: Ensembl
  4. cellular response to lithium ion Source: Ensembl
  5. cellular response to organic cyclic compound Source: Ensembl
  6. extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  7. hypermethylation of CpG island Source: Ensembl
  8. insulin receptor signaling pathway Source: Ensembl
  9. negative regulation of cell growth involved in cardiac muscle cell development Source: Ensembl
  10. negative regulation of TOR signaling Source: Ensembl
  11. positive regulation of adrenergic receptor signaling pathway Source: Ensembl
  12. positive regulation of cAMP biosynthetic process Source: Ensembl
  13. positive regulation of glycogen (starch) synthase activity Source: Ensembl
  14. positive regulation of heart contraction Source: Ensembl
  15. positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Source: Ensembl
  16. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
  17. positive regulation of peptidyl-threonine phosphorylation Source: Ensembl
  18. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  19. proteasome-mediated ubiquitin-dependent protein catabolic process Source: Ensembl
  20. regulation of gene expression by genetic imprinting Source: Ensembl
  21. regulation of systemic arterial blood pressure Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_211201. XBP1(S) activates chaperone genes.
REACT_215895. Constitutive PI3K/AKT Signaling in Cancer.
REACT_222898. AKT phosphorylates targets in the cytosol.

Names & Taxonomyi

Protein namesi
Submitted name:
GSK3A proteinImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:GSK3AImported
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 18

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027660.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00520000055635.
HOGENOMiHOG000233017.
HOVERGENiHBG014652.
KOiK08822.
OMAiFDELRCP.
OrthoDBiEOG7TF78V.
TreeFamiTF101104.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6QLB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGGAPSGGG PGGSGRARTS SFAEPGGGGG GGGGGPGGSA SGPGGSGGGK
60 70 80 90 100
TSVGAMGGGV GASSSGGGPG GSGGGGSGGP GAGTSFPPPG VKLGRDSGKV
110 120 130 140 150
TTVVATLGQG PERSQEVAYT DIKVIGSGSF GVVYQARLAD TRELVAIKKV
160 170 180 190 200
LQDKRFKNRE LQIMRKLDHC NIVRLRYFFY SSGEKKDELY LNLVLEYVPE
210 220 230 240 250
TVYRVARHFT KAKLSIPIIY VKVYMYQLFR SLAYIHSQGV CHRDIKPQNL
260 270 280 290 300
LVDPDTAVLK LCDFGSAKQL VRGEPNVSYI CSRYYRAPEL IFGATDYTSS
310 320 330 340 350
IDVWSAGCVL AELLLGQPIF PGDSGVDQLV EIIKVLGTPS REQIREMNPN
360 370 380 390 400
YTEFKFPQIK AHPWTKVFKS RTPPEAIALC SSLLEYTPSS RLSPLEACAH
410 420 430 440 450
SFFDELRCPG TQLPNNRPLP PLFNFSPGEL TIQPSLNAIL IPPHLRSPAG
460 470 480 490
TASLTPSSQA LSEAQTSSDW QSTDNTATLP PGLHLLQPPH LLCPL
Length:495
Mass (Da):52,263
Last modified:August 21, 2007 - v1
Checksum:iDC13D3A3922F51C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02047214 Genomic DNA. No translation available.
DAAA02047215 Genomic DNA. No translation available.
BC147908 mRNA. Translation: AAI47909.1.
RefSeqiNP_001095662.1. NM_001102192.1.
UniGeneiBt.33944.

Genome annotation databases

EnsembliENSBTAT00000027660; ENSBTAP00000027660; ENSBTAG00000020756.
GeneIDi536561.
KEGGibta:536561.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02047214 Genomic DNA. No translation available.
DAAA02047215 Genomic DNA. No translation available.
BC147908 mRNA. Translation: AAI47909.1.
RefSeqiNP_001095662.1. NM_001102192.1.
UniGeneiBt.33944.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027660.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000027660; ENSBTAP00000027660; ENSBTAG00000020756.
GeneIDi536561.
KEGGibta:536561.

Organism-specific databases

CTDi2931.

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00520000055635.
HOGENOMiHOG000233017.
HOVERGENiHBG014652.
KOiK08822.
OMAiFDELRCP.
OrthoDBiEOG7TF78V.
TreeFamiTF101104.

Enzyme and pathway databases

ReactomeiREACT_211201. XBP1(S) activates chaperone genes.
REACT_215895. Constitutive PI3K/AKT Signaling in Cancer.
REACT_222898. AKT phosphorylates targets in the cytosol.

Miscellaneous databases

NextBioi20876974.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: L1 HerefordImported.
    Tissue: UterusImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HerefordImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: HerefordImported.

Entry informationi

Entry nameiA6QLB8_BOVIN
AccessioniPrimary (citable) accession number: A6QLB8
Secondary accession number(s): F1MHW8
Entry historyi
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: March 4, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.