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Protein

Phosphatidylinositide phosphatase SAC1

Gene

SACM1L

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Phosphoinositide phosphatase that hydrolyzes phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 4-phosphate (PtdIns4P) (By similarity). Has low activity towards PtdIns(3,5)P2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

ReactomeiR-BTA-1483248 Synthesis of PIPs at the ER membrane
R-BTA-1660514 Synthesis of PIPs at the Golgi membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositide phosphatase SAC1 (EC:3.1.3.-)
Alternative name(s):
Suppressor of actin mutations 1-like protein
Gene namesi
Name:SACM1L
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 22

Organism-specific databases

VGNCiVGNC:34259 SACM1L

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Transmembranei521 – 541HelicalSequence analysisAdd BLAST21
Transmembranei549 – 569HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003171701 – 587Phosphatidylinositide phosphatase SAC1Add BLAST587

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei456N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiA6QL88
PRIDEiA6QL88

Expressioni

Gene expression databases

BgeeiENSBTAG00000003501

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004549

Structurei

3D structure databases

SMRiA6QL88
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini122 – 451SACPROSITE-ProRule annotationAdd BLAST330

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1889 Eukaryota
COG5329 LUCA
GeneTreeiENSGT00530000063393
HOGENOMiHOG000189112
HOVERGENiHBG108454
InParanoidiA6QL88
KOiK21797
OMAiMLFWGAM
OrthoDBiEOG091G03I1
TreeFamiTF313543

Family and domain databases

InterProiView protein in InterPro
IPR002013 SAC_dom
PfamiView protein in Pfam
PF02383 Syja_N, 1 hit
PROSITEiView protein in PROSITE
PS50275 SAC, 1 hit

Sequencei

Sequence statusi: Complete.

A6QL88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATTYERLK LHVTPEKFYV EACDDGADDV LIIDRVSTEV TLSVKKDIPP
60 70 80 90 100
SAVTRPIFGI LGTIHLVAGN YLIVITKKKK IGEFFNHVIW KATDFDVLSY
110 120 130 140 150
KKTMLHLTDI QLQDNKTFLA MMNHVLSMDG FYFSTTYDLT HTLQRLSNTS
160 170 180 190 200
PEFQEMSLLE RADQRFVWNG HLLRELSAQP EVHRFALPVL HGFITMHSCS
210 220 230 240 250
INGKYFDWIL ISRRSCFRAG VRYYVRGIDS EGHAANFVET EQIVHYNGSR
260 270 280 290 300
ASFVQTRGSI PLYWSQRPNL KYKPLPLINK VANHMDGFQR HFDSQIIIYG
310 320 330 340 350
KQVIINLVNQ KGSEKPLEQA FATMVSSLGN GMIRYIAFDF HKECKNMRWD
360 370 380 390 400
RLSILLDQVA EMQDELSYFL VDPAGVVLST QEGVFRSNCM DCLDRTNVIQ
410 420 430 440 450
SLLARRSLQA QLQRLGVLHV GQKLEEQDEF EKIYKNAWAD NANACAKQYA
460 470 480 490 500
GTGALKTDFT RTGKRTQLGL IMDGWNSLIR YYKNNFSDGF RQDSIDLFLG
510 520 530 540 550
NYSVDELESH SPLSVPRDLK FLALPIIMVV AFSMCIICLL MAGDTWTETL
560 570 580
AYVLFWGVAS IGTFFIILYN GKDFVDAPRL VQKEKID
Length:587
Mass (Da):67,093
Last modified:August 21, 2007 - v1
Checksum:i91736BEC3ACFC763
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC147878 mRNA Translation: AAI47879.1
RefSeqiNP_001095601.1, NM_001102131.2
UniGeneiBt.13455

Genome annotation databases

EnsembliENSBTAT00000004549; ENSBTAP00000004549; ENSBTAG00000003501
GeneIDi530577
KEGGibta:530577

Similar proteinsi

Entry informationi

Entry nameiSAC1_BOVIN
AccessioniPrimary (citable) accession number: A6QL88
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 21, 2007
Last modified: March 28, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome