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Protein

Ankyrin repeat domain-containing protein 36A

Gene

ANKRD36

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174501-MONOMER.
ZFISH:G66-31501-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 36A
Gene namesi
Name:ANKRD36
Synonyms:ANKRD36A, KIAA1641
ORF Names:UNQ2430/PRO499
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:24079. ANKRD36.

Pathology & Biotechi

Organism-specific databases

DisGeNETi375248.
OpenTargetsiENSG00000135976.

Polymorphism and mutation databases

BioMutaiANKRD36.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003345441 – 1941Ankyrin repeat domain-containing protein 36AAdd BLAST1941

Proteomic databases

EPDiA6QL64.
MaxQBiA6QL64.
PaxDbiA6QL64.
PRIDEiA6QL64.

PTM databases

iPTMnetiA6QL64.
PhosphoSitePlusiA6QL64.

Expressioni

Gene expression databases

BgeeiENSG00000135976.
ExpressionAtlasiA6QL64. baseline and differential.
GenevisibleiA6QL64. HS.

Interactioni

Protein-protein interaction databases

BioGridi131962. 3 interactors.
STRINGi9606.ENSP00000391950.

Structurei

3D structure databases

ProteinModelPortaliA6QL64.
SMRiA6QL64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati31 – 60ANK 1Add BLAST30
Repeati64 – 93ANK 2Add BLAST30
Repeati97 – 126ANK 3Add BLAST30
Repeati130 – 159ANK 4Add BLAST30
Repeati163 – 192ANK 5Add BLAST30
Repeati196 – 225ANK 6Add BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1319 – 1350Sequence analysisAdd BLAST32
Coiled coili1409 – 1494Sequence analysisAdd BLAST86
Coiled coili1525 – 1643Sequence analysisAdd BLAST119
Coiled coili1707 – 1932Sequence analysisAdd BLAST226

Sequence similaritiesi

Belongs to the ANKRD36 family.Curated
Contains 6 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00560000076605.
HOGENOMiHOG000185155.
HOVERGENiHBG108636.
InParanoidiA6QL64.
OMAiYERERWP.
OrthoDBiEOG091G01X9.
PhylomeDBiA6QL64.
TreeFamiTF333496.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A6QL64-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEDGKRERWP TLMERLCSDG FAFPQYPIKP YHLKRIHRAV LHGNLEKLKY
60 70 80 90 100
LLLTYYDANK RDRKERTALH LACATGQPEM VHLLVSRRCE LNLCDREDRT
110 120 130 140 150
PLIKAVQLRQ EACATLLLQN GANPNITDFF GRTALHYAVY NEDTSMIEKL
160 170 180 190 200
LSHGTNIEEC SKCEYQPLLF AVSRRKVKMV EFLLKKKANV NAIDYLGRSA
210 220 230 240 250
LIHAVTLGEK DIVILLLQHN IDVLSRDAFR KIAGDYAIEA KNRVIFDLIY
260 270 280 290 300
EYERKRYEDL PINSNPVSSQ KQPALKATSG KEDSISNIAT EIKDGQKSGT
310 320 330 340 350
VSSQKQPALK DTSDKDDSVS NTATEIKDEQ KSGTVLPAVE QCLNRSLYRP
360 370 380 390 400
DAVAQPVTEN EFSLESEIIS KLYIPKRKII SPRSIKDVLP PVEEAVDRCL
410 420 430 440 450
YLLDRFAQPV TKDKFALESE NISEPYFTNR RTISQQSAEN LDAACGIDKT
460 470 480 490 500
ENGNMFEDQN VDKEGKALPA TGQKANVSPE QPPLFTHTVK DRDHISTRFL
510 520 530 540 550
GGMDSLTSSE ESSERPPLST LTLKEADPSS KAAMRRKDSP PPGKVSSQKQ
560 570 580 590 600
PAEKATSDDK DSVSNIATEI KEGPISGTVS SQKQPAEKAT SDEKDSVSNI
610 620 630 640 650
ATEIKKGQQS GTVSPQKQSA WKVIFKKKVS LLNIATRIMG GGKSGTVSSQ
660 670 680 690 700
KQPASKATSD KTDSALNIAT EIKDGLQCGT VSSQKQPALK ATTDEEDSVS
710 720 730 740 750
NIATEIKDGE KSGTVSSQKQ PALKATTDEE DSVSNIATEI KDGEKSGTVS
760 770 780 790 800
SQKQPALKAT TDEKDSVSNI ATEIKDGEKS GTVSSQKPPA LTATSDEEGS
810 820 830 840 850
VLSIARENKD GEKSRTVSSR KKPALKATSD EKDSFSNITR GKKDGEISRK
860 870 880 890 900
VSSQKPPTLK GTSDEEDSVL GIARENKDGE KSRTVSSEKP PGLKASSAEK
910 920 930 940 950
DSVLNIARGK KDGEKTKRVS SRKKPSLEAT SDEKDSFSNI TREKKDGEIS
960 970 980 990 1000
RKVSSQKPPA LKGTSDEEDS VLGIARENKD GEKSRTVSSE KPPGLKATSD
1010 1020 1030 1040 1050
EKDSVLNIAR GKKDGEKTRT VSSQKPPTLK ATSDEEDSVL SIARENKDGE
1060 1070 1080 1090 1100
KSRTVSSEKP SGLKATSAEK DSVLNIARGK KYGEKTKRVS SRKKPALKAT
1110 1120 1130 1140 1150
SDEKDSVLYI AREKKDGEKS RTVSSPKQPA LKAICDKEDS VPNMATEKKD
1160 1170 1180 1190 1200
EQISGTVSCQ KQPALKATSD KKDSVSNIPT EIKDGQQSGT VSSQKQPAWK
1210 1220 1230 1240 1250
ATSVKKDSVS NIATEIKDGQ IRGTGILEYT FNVMFDQIEE KFTSLNKSAG
1260 1270 1280 1290 1300
VSPQKQSAQK VIFKKKVSLL NIATRITGGW KSGTEYPENL PTLKATIENK
1310 1320 1330 1340 1350
NSVLNTATKM KDVQTSTPAE QDLEMASEGE QKRLEEYENN QPQVKNQIHS
1360 1370 1380 1390 1400
RDDLDDIIQS SQTVSEDGDS LCCNCKNVIL LIDQHEMKCK DCVHLLKIKN
1410 1420 1430 1440 1450
TFCLWKRLIK LKDNHCEQLR VKIRKLKNKA SVLQKRISEK EEIKSQLKHE
1460 1470 1480 1490 1500
ILELEKELCS LRFAIQQEKK KRRNVEEVHQ KVREKLRITE EQYRIEADVT
1510 1520 1530 1540 1550
KPIKPALKSA EVELKTGGNN SNQVSETDEK EDLLHENRLM QDEIARLRLE
1560 1570 1580 1590 1600
KDTIKNQNLE KKYLKDFEIV KRKHEDLQKA LKRNGETLAK TIACYSGQLA
1610 1620 1630 1640 1650
ALTDENTTLR SKLEKQRESR QRLETEMQSY HCRLNAARCD HDQSHSSKRD
1660 1670 1680 1690 1700
QELAFQGTVD KCRHLQENLN SHVLILSLQL SKAESKSRVL KTELHYTGEA
1710 1720 1730 1740 1750
LKEKALVFEH VQSELKQKQS QMKDIEKMYK SGYNTMEKCI EKQERFCQLK
1760 1770 1780 1790 1800
KQNMLLQQQL DDARNKADNQ EKAILNIQAR CDARVQNLQA ECRKHRLLLE
1810 1820 1830 1840 1850
EDNKMLVNEL NHSKEKECQY EKEKAEREVA VRQLQQKRDD VLNKGSATKA
1860 1870 1880 1890 1900
LLDASSRHCT YLENGMQDSR KKLDQMRSQF QEIQDQLTAT IRCTKEMEGD
1910 1920 1930 1940
TQKLEVEHVM MRKIIKKQDD QIERLEKILQ HSSLMLQVFE S
Length:1,941
Mass (Da):217,465
Last modified:August 10, 2010 - v3
Checksum:iDF492CB9ED173FE6
GO
Isoform 2 (identifier: A6QL64-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1149: Missing.
     1150-1159: DEQISGTVSC → MYPFCFSVSS
     1225-1250: Missing.
     1319-1319: Missing.
     1880-1892: FQEIQDQLTATIR → VCMQLCTPTTVNL
     1893-1941: Missing.

Show »
Length:716
Mass (Da):82,759
Checksum:iE5BCF1176718C9EA
GO
Isoform 3 (identifier: A6QL64-4) [UniParc] [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     163-163: C → V
     164-1941: Missing.

Show »
Length:163
Mass (Da):18,915
Checksum:i0609BBDE2633E175
GO
Isoform 4 (identifier: A6QL64-5) [UniParc] [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     164-170: EYQPLLF → LLRNNQP
     171-1941: Missing.

Show »
Length:170
Mass (Da):19,755
Checksum:i3ABC2357DB54D12A
GO

Sequence cautioni

The sequence AAQ88934 differs from that shown. Reason: Frameshift at position 5.Curated
The sequence AAQ88934 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB13467 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0396561 – 1149Missing in isoform 2. 3 PublicationsAdd BLAST1149
Alternative sequenceiVSP_039657163C → V in isoform 3. 2 Publications1
Alternative sequenceiVSP_039658164 – 1941Missing in isoform 3. 2 PublicationsAdd BLAST1778
Alternative sequenceiVSP_039659164 – 170EYQPLLF → LLRNNQP in isoform 4. 1 Publication7
Alternative sequenceiVSP_039660171 – 1941Missing in isoform 4. 1 PublicationAdd BLAST1771
Alternative sequenceiVSP_0396611150 – 1159DEQISGTVSC → MYPFCFSVSS in isoform 2. 3 Publications10
Alternative sequenceiVSP_0396621225 – 1250Missing in isoform 2. 3 PublicationsAdd BLAST26
Alternative sequenceiVSP_0396631319Missing in isoform 2. 3 Publications1
Alternative sequenceiVSP_0396641880 – 1892FQEIQ…TATIR → VCMQLCTPTTVNL in isoform 2. 3 PublicationsAdd BLAST13
Alternative sequenceiVSP_0396651893 – 1941Missing in isoform 2. 3 PublicationsAdd BLAST49

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046861 mRNA. Translation: BAB13467.1. Different initiation.
AY358571 mRNA. Translation: AAQ88934.1. Sequence problems.
AK304740 mRNA. Translation: BAG65500.1.
AK316541 mRNA. Translation: BAH14912.1.
AC018892 Genomic DNA. Translation: AAY14642.1.
BC046186 mRNA. Translation: AAH46186.1.
BC146835 mRNA. Translation: AAI46836.1.
AF543495 mRNA. Translation: AAN40505.1.
CCDSiCCDS54379.1. [A6QL64-1]
RefSeqiNP_001157787.1. NM_001164315.1. [A6QL64-1]
UniGeneiHs.541894.

Genome annotation databases

EnsembliENST00000420699; ENSP00000391950; ENSG00000135976. [A6QL64-1]
ENST00000461153; ENSP00000419530; ENSG00000135976. [A6QL64-1]
GeneIDi375248.
KEGGihsa:375248.
UCSCiuc010yva.3. human. [A6QL64-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046861 mRNA. Translation: BAB13467.1. Different initiation.
AY358571 mRNA. Translation: AAQ88934.1. Sequence problems.
AK304740 mRNA. Translation: BAG65500.1.
AK316541 mRNA. Translation: BAH14912.1.
AC018892 Genomic DNA. Translation: AAY14642.1.
BC046186 mRNA. Translation: AAH46186.1.
BC146835 mRNA. Translation: AAI46836.1.
AF543495 mRNA. Translation: AAN40505.1.
CCDSiCCDS54379.1. [A6QL64-1]
RefSeqiNP_001157787.1. NM_001164315.1. [A6QL64-1]
UniGeneiHs.541894.

3D structure databases

ProteinModelPortaliA6QL64.
SMRiA6QL64.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131962. 3 interactors.
STRINGi9606.ENSP00000391950.

PTM databases

iPTMnetiA6QL64.
PhosphoSitePlusiA6QL64.

Polymorphism and mutation databases

BioMutaiANKRD36.

Proteomic databases

EPDiA6QL64.
MaxQBiA6QL64.
PaxDbiA6QL64.
PRIDEiA6QL64.

Protocols and materials databases

DNASUi375248.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000420699; ENSP00000391950; ENSG00000135976. [A6QL64-1]
ENST00000461153; ENSP00000419530; ENSG00000135976. [A6QL64-1]
GeneIDi375248.
KEGGihsa:375248.
UCSCiuc010yva.3. human. [A6QL64-1]

Organism-specific databases

CTDi375248.
DisGeNETi375248.
GeneCardsiANKRD36.
H-InvDBHIX0002250.
HIX0161601.
HGNCiHGNC:24079. ANKRD36.
neXtProtiNX_A6QL64.
OpenTargetsiENSG00000135976.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00560000076605.
HOGENOMiHOG000185155.
HOVERGENiHBG108636.
InParanoidiA6QL64.
OMAiYERERWP.
OrthoDBiEOG091G01X9.
PhylomeDBiA6QL64.
TreeFamiTF333496.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174501-MONOMER.
ZFISH:G66-31501-MONOMER.

Miscellaneous databases

ChiTaRSiANKRD36. human.
GenomeRNAii375248.
PROiA6QL64.

Gene expression databases

BgeeiENSG00000135976.
ExpressionAtlasiA6QL64. baseline and differential.
GenevisibleiA6QL64. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAN36A_HUMAN
AccessioniPrimary (citable) accession number: A6QL64
Secondary accession number(s): B4E3I8
, Q6UX02, Q86X62, Q9HCD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 10, 2010
Last modified: November 2, 2016
This is version 72 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.