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Protein

Interleukin-34

Gene

IL34

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1 (By similarity).By similarity

GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • growth factor activity Source: UniProtKB-KW
  • macrophage colony-stimulating factor receptor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor
Biological processImmunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

ReactomeiR-BTA-449836 Other interleukin signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-34By similarity
Short name:
IL-34By similarity
Gene namesi
Name:IL34Imported
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Organism-specific databases

VGNCiVGNC:30156 IL34

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000034727621 – 234Interleukin-34Sequence analysisAdd BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi76N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiA6QL48
PRIDEiA6QL48

Expressioni

Gene expression databases

BgeeiENSBTAG00000009357

Interactioni

Subunit structurei

Homodimer. Interacts with CSF1R (By similarity).By similarity

GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • growth factor activity Source: UniProtKB-KW
  • macrophage colony-stimulating factor receptor binding Source: UniProtKB

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000046513

Structurei

3D structure databases

SMRiA6QL48
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-34 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IX9Y Eukaryota
ENOG410Z6RS LUCA
GeneTreeiENSGT00390000000932
HOGENOMiHOG000113048
HOVERGENiHBG108003
InParanoidiA6QL48
OMAiCEVPSPQ
OrthoDBiEOG091G0I1D
TreeFamiTF337386

Family and domain databases

Gene3Di1.20.1250.80, 1 hit
InterProiView protein in InterPro
IPR020415 IL-34
IPR038328 IL-34_sf
PANTHERiPTHR28606 PTHR28606, 1 hit
PfamiView protein in Pfam
PF15036 IL34, 1 hit
PRINTSiPR01938 INTRLEUKIN34

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6QL48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQGLAWLRY LGILLGMALG NEGLEPWPLT RSDECAITGF LRDKLQYRNR
60 70 80 90 100
LQYMKHYFPI NYRVSVPYEG VLRTANVTRL QRAQVSQQEL RYLWVLVSLS
110 120 130 140 150
ATEWVQEVLL EGHPSWKYLE EVHTLLLDVK QGLGGVEVSP QVEAVLNLLS
160 170 180 190 200
APGSLKLVRP KALLDNCFRV MQLLYCPCCK ESSVLNWQDC EAPQPQPRSP
210 220 230
ASAQCEAAQL YPLPQPPSTS LPRVLGPSAG PPTQ
Length:234
Mass (Da):26,294
Last modified:August 21, 2007 - v1
Checksum:i2156564089E5D818
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC146187 mRNA Translation: AAI46188.1
RefSeqiNP_001093794.1, NM_001100324.2
XP_005218384.1, XM_005218327.3
XP_005218387.1, XM_005218330.3
XP_005218388.1, XM_005218331.3
XP_010812596.1, XM_010814294.2
XP_010812597.1, XM_010814295.2
XP_010812598.1, XM_010814296.2
XP_010812599.1, XM_010814297.2
UniGeneiBt.53591

Genome annotation databases

EnsembliENSBTAT00000049652; ENSBTAP00000046513; ENSBTAG00000009357
GeneIDi508292
KEGGibta:508292

Similar proteinsi

Entry informationi

Entry nameiIL34_BOVIN
AccessioniPrimary (citable) accession number: A6QL48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: August 21, 2007
Last modified: May 23, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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