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Protein

Interleukin-34

Gene

IL34

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1 (By similarity).By similarity

GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • growth factor activity Source: UniProtKB-KW
  • macrophage colony-stimulating factor receptor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor
Biological processImmunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

ReactomeiR-BTA-449836. Other interleukin signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-34By similarity
Short name:
IL-34By similarity
Gene namesi
Name:IL34Imported
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

  • extracellular space Source: UniProtKB

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000034727621 – 234Interleukin-34Sequence analysisAdd BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi76N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiA6QL48.

Expressioni

Gene expression databases

BgeeiENSBTAG00000009357.

Interactioni

Subunit structurei

Homodimer. Interacts with CSF1R (By similarity).By similarity

GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • growth factor activity Source: UniProtKB-KW
  • macrophage colony-stimulating factor receptor binding Source: UniProtKB

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000046513.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-34 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IX9Y. Eukaryota.
ENOG410Z6RS. LUCA.
GeneTreeiENSGT00390000000932.
HOGENOMiHOG000113048.
HOVERGENiHBG108003.
InParanoidiA6QL48.
OMAiCEVPSPQ.
OrthoDBiEOG091G0I1D.
TreeFamiTF337386.

Family and domain databases

InterProiView protein in InterPro
IPR020415. IL-34.
PfamiView protein in Pfam
PF15036. IL34. 1 hit.
PRINTSiPR01938. INTRLEUKIN34.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6QL48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQGLAWLRY LGILLGMALG NEGLEPWPLT RSDECAITGF LRDKLQYRNR
60 70 80 90 100
LQYMKHYFPI NYRVSVPYEG VLRTANVTRL QRAQVSQQEL RYLWVLVSLS
110 120 130 140 150
ATEWVQEVLL EGHPSWKYLE EVHTLLLDVK QGLGGVEVSP QVEAVLNLLS
160 170 180 190 200
APGSLKLVRP KALLDNCFRV MQLLYCPCCK ESSVLNWQDC EAPQPQPRSP
210 220 230
ASAQCEAAQL YPLPQPPSTS LPRVLGPSAG PPTQ
Length:234
Mass (Da):26,294
Last modified:August 21, 2007 - v1
Checksum:i2156564089E5D818
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC146187 mRNA. Translation: AAI46188.1.
RefSeqiNP_001093794.1. NM_001100324.2.
XP_005218384.1. XM_005218327.3.
XP_005218387.1. XM_005218330.3.
XP_005218388.1. XM_005218331.3.
XP_010812596.1. XM_010814294.2.
XP_010812597.1. XM_010814295.2.
XP_010812598.1. XM_010814296.2.
XP_010812599.1. XM_010814297.2.
UniGeneiBt.53591.

Genome annotation databases

EnsembliENSBTAT00000049652; ENSBTAP00000046513; ENSBTAG00000009357.
GeneIDi508292.
KEGGibta:508292.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiIL34_BOVIN
AccessioniPrimary (citable) accession number: A6QL48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: August 21, 2007
Last modified: June 7, 2017
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families