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A6QK93

- ALF1_STAAE

UniProt

A6QK93 - ALF1_STAAE

Protein

Fructose-bisphosphate aldolase class 1

Gene

fda

Organism
Staphylococcus aureus (strain Newman)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei175 – 1751Proton acceptorUniRule annotation
    Active sitei212 – 2121Schiff-base intermediate with dihydroxyacetone-PUniRule annotation

    GO - Molecular functioni

    1. fructose-bisphosphate aldolase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Schiff base

    Enzyme and pathway databases

    BioCyciSAUR426430:GIXC-2576-MONOMER.
    UniPathwayiUPA00109; UER00183.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fructose-bisphosphate aldolase class 1UniRule annotation (EC:4.1.2.13UniRule annotation)
    Alternative name(s):
    Fructose-bisphosphate aldolase class I
    Short name:
    FBP aldolaseUniRule annotation
    Gene namesi
    Name:fdaUniRule annotation
    Ordered Locus Names:NWMN_2503
    OrganismiStaphylococcus aureus (strain Newman)
    Taxonomic identifieri426430 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000006386: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 296296Fructose-bisphosphate aldolase class 1PRO_1000072783Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi426430.NWMN_2503.

    Structurei

    3D structure databases

    ProteinModelPortaliA6QK93.
    SMRiA6QK93. Positions 1-293.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I fructose-bisphosphate aldolase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG3588.
    HOGENOMiHOG000073502.
    KOiK01623.
    OMAiYTGDYLA.
    OrthoDBiEOG6M6JJT.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00729. FBP_aldolase_1.
    InterProiIPR013785. Aldolase_TIM.
    IPR000741. FBA_I.
    IPR023014. FBA_I_Gram+-type.
    [Graphical view]
    PfamiPF00274. Glycolytic. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6QK93-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNKEQLEKMK NGKGFIAALD QSGGSTPKAL KEYGVNEDQY SNEDEMFQLV    50
    HDMRTRVVTS PSFSPDKILG AILFEQTMDR EVESKYTADY LADKGVVPFL 100
    KVDKGLAEEQ NGVQLMKPID NLDNLLDRAN ERHIFGTKMR SNILELNEQG 150
    IKDVVEQQFE VAKQIIAKGL VPIIEPEVNI NAKDKAEIEK VLKAELKKGL 200
    DSLNADQLVM LKLTIPTEPN LYKELAEHPN VVRVVVLSGG YSREKANELL 250
    KDNAELIASF SRALASDLRA DQSKEEFDKA LGDAVESIYD ASVNKN 296
    Length:296
    Mass (Da):33,055
    Last modified:August 21, 2007 - v1
    Checksum:i610A2E2FBDA7EB5F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009351 Genomic DNA. Translation: BAF68775.1.
    RefSeqiYP_001333537.1. NC_009641.1.

    Genome annotation databases

    EnsemblBacteriaiBAF68775; BAF68775; NWMN_2503.
    GeneIDi5331554.
    KEGGisae:NWMN_2503.
    PATRICi19588878. VBIStaAur133992_2714.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009351 Genomic DNA. Translation: BAF68775.1 .
    RefSeqi YP_001333537.1. NC_009641.1.

    3D structure databases

    ProteinModelPortali A6QK93.
    SMRi A6QK93. Positions 1-293.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 426430.NWMN_2503.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAF68775 ; BAF68775 ; NWMN_2503 .
    GeneIDi 5331554.
    KEGGi sae:NWMN_2503.
    PATRICi 19588878. VBIStaAur133992_2714.

    Phylogenomic databases

    eggNOGi COG3588.
    HOGENOMi HOG000073502.
    KOi K01623.
    OMAi YTGDYLA.
    OrthoDBi EOG6M6JJT.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00183 .
    BioCyci SAUR426430:GIXC-2576-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00729. FBP_aldolase_1.
    InterProi IPR013785. Aldolase_TIM.
    IPR000741. FBA_I.
    IPR023014. FBA_I_Gram+-type.
    [Graphical view ]
    Pfami PF00274. Glycolytic. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Staphylococcus aureus strain Newman and comparative analysis of staphylococcal genomes: polymorphism and evolution of two major pathogenicity islands."
      Baba T., Bae T., Schneewind O., Takeuchi F., Hiramatsu K.
      J. Bacteriol. 190:300-310(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Newman.

    Entry informationi

    Entry nameiALF1_STAAE
    AccessioniPrimary (citable) accession number: A6QK93
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3