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Protein

Copper-exporting P-type ATPase

Gene

copA

Organism
Staphylococcus aureus (strain Newman)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in copper export.By similarity

Catalytic activityi

ATP + H2O + Cu+(Side 1) = ADP + phosphate + Cu+(Side 2).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi16Copper 1PROSITE-ProRule annotation1
Metal bindingi19Copper 1PROSITE-ProRule annotation1
Metal bindingi83Copper 2PROSITE-ProRule annotation1
Metal bindingi86Copper 2PROSITE-ProRule annotation1
Active sitei4954-aspartylphosphate intermediateBy similarity1
Metal bindingi690MagnesiumPROSITE-ProRule annotation1
Metal bindingi694MagnesiumPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCopper transport, Ion transport, Transport
LigandATP-binding, Copper, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Copper-exporting P-type ATPase (EC:3.6.3.54)
Alternative name(s):
Copper-exporting P-type ATPase A
Cu(+)-exporting ATPase
Gene namesi
Name:copA
Ordered Locus Names:NWMN_2457
OrganismiStaphylococcus aureus (strain Newman)
Taxonomic identifieri426430 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000006386 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21
Transmembranei411 – 431HelicalSequence analysisAdd BLAST21
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Transmembranei748 – 767HelicalSequence analysisAdd BLAST20
Transmembranei771 – 790HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003505941 – 802Copper-exporting P-type ATPaseAdd BLAST802

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliA6QK47
SMRiA6QK47
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 71HMA 1PROSITE-ProRule annotationAdd BLAST66
Domaini73 – 139HMA 2PROSITE-ProRule annotationAdd BLAST67

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000250397
KOiK17686
OMAiHIFGGPL

Family and domain databases

CDDicd00371 HMA, 2 hits
Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR017969 Heavy-metal-associated_CS
IPR006122 HMA_Cu_ion-bd
IPR006121 HMA_dom
IPR036163 HMA_dom_sf
IPR027256 P-typ_ATPase_IB
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00403 HMA, 2 hits
SUPFAMiSSF55008 SSF55008, 2 hits
SSF56784 SSF56784, 2 hits
SSF81653 SSF81653, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01525 ATPase-IB_hvy, 1 hit
TIGR01494 ATPase_P-type, 1 hit
TIGR00003 TIGR00003, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
PS01047 HMA_1, 2 hits
PS50846 HMA_2, 2 hits

Sequencei

Sequence statusi: Complete.

A6QK47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANTKKTTLD ITGMTCAACS NRIEKKLNKL DDVNAQVNLT TEKATVEYNP
60 70 80 90 100
DQHDVQEFIN TIQHLGYGVA VETVELDITG MTCAACSSRI EKVLNKMDGV
110 120 130 140 150
QNATVNLTTE QAKVDYYPEE TDADKLVTRI QKLGYDASIK DNNKDQTSRK
160 170 180 190 200
AEALQHKLIK LIISAVLSLP LLMLMFVHLF NMHIPALFTN PWFQFILATP
210 220 230 240 250
VQFIIGWQFY VGAYKNLRNG GANMDVLVAV GTSAAYFYSI YEMVRWLNGS
260 270 280 290 300
TTQPHLYFET SAVLITLILF GKYLEARAKS QTTNALGELL SLQAKEARIL
310 320 330 340 350
KDGNEVMIPL NEVHVGDTLI VKPGEKIPVD GKIIKGMTAI DESMLTGESI
360 370 380 390 400
PVEKNVDDTV IGSTMNKNGT ITMTATKVGG DTALANIIKV VEEAQSSKAP
410 420 430 440 450
IQRLADIISG YFVPIVVGIA LLTFIVWITL VTPGTFEPAL VASISVLVIA
460 470 480 490 500
CPCALGLATP TSIMVGTGRA AENGILFKGG EFVERTHQID TIVLDKTGTI
510 520 530 540 550
TNGRPVVTDY HGDNQTLQLL ATAEKDSEHP LAEAIVNYAK EKQLILTETT
560 570 580 590 600
TFKAVPGHGI EATIDHHHIL VGNRKLMADN DISLPKHISD DLTHYERDGK
610 620 630 640 650
TAMLIAVNYS LTGIIAVADT VKDHAKDAIK QLHDMGIEVA MLTGDNKNTA
660 670 680 690 700
QAIAKQVGID TVIADILPEE KAAQIAKLQQ QGKKVAMVGD GVNDAPALVK
710 720 730 740 750
ADIGIAIGTG TEVAIEAADI TILGGDLMLI PKAIYASKAT IRNIRQNLFW
760 770 780 790 800
AFGYNIAGIP IAALGLLAPW VAGAAMALSS VSVVTNALRL KKMRLEPRRK

DA
Length:802
Mass (Da):86,744
Last modified:August 21, 2007 - v1
Checksum:i23B26C2ED46A9E69
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009351 Genomic DNA Translation: BAF68729.1
RefSeqiWP_000024127.1, NZ_CP023390.1

Genome annotation databases

EnsemblBacteriaiBAF68729; BAF68729; NWMN_2457
KEGGisae:NWMN_2457

Similar proteinsi

Entry informationi

Entry nameiCOPA_STAAE
AccessioniPrimary (citable) accession number: A6QK47
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 23, 2008
Last sequence update: August 21, 2007
Last modified: March 28, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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