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A6QK35 (A6QK35_STAAE) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesSubmitted name:
Hydroxymethylglutaryl-CoA reductase, degradative EMBL BAF68717.1
Gene names
Name:mvaA EMBL BAF68717.1
Ordered Locus Names:NWMN_2445
OrganismStaphylococcus aureus (strain Newman) [Complete proteome] [HAMAP]
Taxonomic identifier426430 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length425 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the HMG-CoA reductase family. RuleBase RU004268

Ontologies

Keywords
   Molecular functionOxidoreductase RuleBase RU004269
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcoenzyme A metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functioncoenzyme binding

Inferred from electronic annotation. Source: InterPro

hydroxymethylglutaryl-CoA reductase (NADPH) activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
A6QK35 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 93338FC55C2DD044

FASTA42546,237
        10         20         30         40         50         60 
MQNLDKNFRH LSRKEKLQQL VDKQWLSEEQ FDILLNHPLI DEEVANSLIE NVIAQGALPV 

        70         80         90        100        110        120 
GLLPNIIVDD KAYVVPMMVE EPSVVAAASY GAKLVNQTGG FKTVSSERIM IGQIVFDGVD 

       130        140        150        160        170        180 
DTEKLSADIK ALEKQIHKIA DEAYPSIKAR GGGYQRIAID TFPEQQLLSL KVFVDTKDAM 

       190        200        210        220        230        240 
GANMLNTILE AITAFLKNEF PQSDILMSIL SNHATASVVK VQGEIDVKDL ARGERTGEEV 

       250        260        270        280        290        300 
AKRMERASVL AQVDIHRAAT HNKGVMNGIH AVVLATGNDT RGAEASAHAY ASRDGQYRGI 

       310        320        330        340        350        360 
ATWRYDQDRQ RLIGTIEVPM TLAIVGGGTK VLPIAKASLE LLNVESAQEL GHVVAAVGLA 

       370        380        390        400        410        420 
QNFAACRALV SEGIQQGHMS LQYKSLAIVV GAKGDEIAKV AEALKKEPRA NTQAAEHILQ 


EIRQQ

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References

[1]"Genome sequence of Staphylococcus aureus strain Newman and comparative analysis of staphylococcal genomes: polymorphism and evolution of two major pathogenicity islands."
Baba T., Bae T., Schneewind O., Takeuchi F., Hiramatsu K.
J. Bacteriol. 190:300-310(2008) [PubMed: 17951380] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP009351 Genomic DNA. Translation: BAF68717.1.
RefSeqYP_001333479.1. NC_009641.1.

3D structure databases

ProteinModelPortalA6QK35.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6QK35.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000031574; EBSTAP00000030444; EBSTAG00000031572.
GeneID5331511.
GenomeReviewsGene locus NWMN_2445 in contig AP009351_GR.
KEGGsae:NWMN_2445.
PATRIC19588758. VBIStaAur133992_2654.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1257.
GeneTreeEBGT00050000024128.
HOGENOMHBG477902.
OMANNKGIMN.
ProtClustDBCLSK886059.

Enzyme and pathway databases

BioCycSAUR426430:NWMN_2445-MONOMER.

Family and domain databases

InterProIPR002202. HMG_CoA_Rdtase.
IPR004553. HMG_CoA_Rdtase_bac-typ.
IPR023074. HMG_CoA_Rdtase_cat.
IPR023076. HMG_CoA_Rdtase_CS.
IPR009023. HMG_CoA_Rdtase_NAD(P)-bd.
IPR009029. HMG_CoA_Rdtase_sub-bd.
[Graphical view]
Gene3DG3DSA:3.30.70.420. G3DSA:3.30.70.420. 1 hit.
G3DSA:3.90.770.10. HMG-CoA_red. 2 hits.
KOK00054.
PfamPF00368. HMG-CoA_red. 1 hit.
[Graphical view]
PRINTSPR00071. HMGCOARDTASE.
SUPFAMSSF55035. HMG_CoA_NAD_bind. 1 hit.
SSF56542. HMG_CoA_sub_bind. 1 hit.
TIGRFAMsTIGR00532. HMG_CoA_R_NAD. 1 hit.
PROSITEPS00066. HMG_COA_REDUCTASE_1. 1 hit.
PS01192. HMG_COA_REDUCTASE_3. 1 hit.
PS50065. HMG_COA_REDUCTASE_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA6QK35_STAAE
AccessionPrimary (citable) accession number: A6QK35
Entry history
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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