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Protein

Probable molybdenum cofactor guanylyltransferase

Gene

mobA

Organism
Staphylococcus aureus (strain Newman)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.UniRule annotation

Catalytic activityi

GTP + molybdenum cofactor = diphosphate + guanylyl molybdenum cofactor.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei18 – 181GTPUniRule annotation
Binding sitei65 – 651GTPUniRule annotation
Metal bindingi97 – 971MagnesiumUniRule annotation
Binding sitei97 – 971GTPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi6 – 83GTPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Molybdenum cofactor biosynthesis

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAUR426430:GIXC-2242-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable molybdenum cofactor guanylyltransferaseUniRule annotation (EC:2.7.7.77UniRule annotation)
Short name:
MoCo guanylyltransferaseUniRule annotation
Alternative name(s):
GTP:molybdopterin guanylyltransferaseUniRule annotation
Mo-MPT guanylyltransferaseUniRule annotation
Molybdopterin guanylyltransferaseUniRule annotation
Molybdopterin-guanine dinucleotide synthaseUniRule annotation
Short name:
MGD synthaseUniRule annotation
Gene namesi
Name:mobAUniRule annotation
Ordered Locus Names:NWMN_2169
OrganismiStaphylococcus aureus (strain Newman)
Taxonomic identifieri426430 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000006386 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 199199Probable molybdenum cofactor guanylyltransferasePRO_1000072002Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA6QJA9.
SMRiA6QJA9. Positions 5-157.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.UniRule annotation

Sequence similaritiesi

Belongs to the MobA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000280425.
KOiK03752.
OMAiGLYHFMV.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_00316. MobA. 1 hit.
InterProiIPR025877. MobA-like_NTP_Trfase.
IPR013482. Molybde_CF_guanTrfase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF12804. NTP_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

A6QJA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAIILAGGH SVRFGKPKAF AEVNGETFYS RVIKTLESTN MFNEIIISTN
60 70 80 90 100
AQLATQFKYP NVVIDDENHN DKGPLAGIYT IMKQHPEEEL FFVVSVDTPM
110 120 130 140 150
ITGKAVSTLY QFLVSHLIEN HLDVAAFKED GRFIPTIAFY SPNALGAITK
160 170 180 190
ALHSDNYSFK NVYHELSTDY LDVRDVDAPS YWYKNINYQH DLDALIQKL
Length:199
Mass (Da):22,542
Last modified:August 21, 2007 - v1
Checksum:i049B67072F209982
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009351 Genomic DNA. Translation: BAF68441.1.
RefSeqiWP_000643988.1. NC_009641.1.

Genome annotation databases

EnsemblBacteriaiBAF68441; BAF68441; NWMN_2169.
KEGGisae:NWMN_2169.
PATRICi19588169. VBIStaAur133992_2360.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009351 Genomic DNA. Translation: BAF68441.1.
RefSeqiWP_000643988.1. NC_009641.1.

3D structure databases

ProteinModelPortaliA6QJA9.
SMRiA6QJA9. Positions 5-157.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAF68441; BAF68441; NWMN_2169.
KEGGisae:NWMN_2169.
PATRICi19588169. VBIStaAur133992_2360.

Phylogenomic databases

HOGENOMiHOG000280425.
KOiK03752.
OMAiGLYHFMV.

Enzyme and pathway databases

BioCyciSAUR426430:GIXC-2242-MONOMER.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_00316. MobA. 1 hit.
InterProiIPR025877. MobA-like_NTP_Trfase.
IPR013482. Molybde_CF_guanTrfase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF12804. NTP_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMOBA_STAAE
AccessioniPrimary (citable) accession number: A6QJA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: August 21, 2007
Last modified: September 7, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.