A6QIW3 (A6QIW3_STAAE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Thymidine kinase HAMAP MF_00124 RuleBase RU000544
EC=2.7.1.21 HAMAP MF_00124 RuleBase RU000544

Gene names

Name:	tdk HAMAP MF_00124 EMBL BAF68295.1
Ordered Locus Names:	NWMN_2023

Organism

Staphylococcus aureus (strain Newman) [Complete proteome] [HAMAP]

Taxonomic identifier

426430 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	199 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + thymidine = ADP + thymidine 5'-phosphate. HAMAP MF_00124 RuleBase RU000544 SAAS SAAS020634
Subunit structure	Homotetramer By similarity. HAMAP MF_00124 SAAS SAAS020634
Subcellular location	Cytoplasm By similarity HAMAP MF_00124 SAAS SAAS020634.
Sequence similarities	Belongs to the thymidine kinase family. HAMAP MF_00124 RuleBase RU004165

Ontologies

Keywords
Biological process	DNA synthesis HAMAP MF_00124 SAAS SAAS020634 RuleBase RU000544
Cellular component	Cytoplasm HAMAP MF_00124 SAAS SAAS020634
Ligand	ATP-binding HAMAP MF_00124 SAAS SAAS020634 RuleBase RU000544 Metal-binding HAMAP MF_00124 SAAS SAAS020634 Nucleotide-binding Zinc HAMAP MF_00124 SAAS SAAS020634
Molecular function	Kinase HAMAP MF_00124 SAAS SAAS020634 RuleBase RU000544 EMBL BAF68295.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP thymidine kinase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	15 – 22	8	ATP By similarity HAMAP MF_00124
	Nucleotide binding	88 – 91	4	ATP By similarity HAMAP MF_00124
Sites
	Active site	89	1	Proton acceptor By similarity HAMAP MF_00124
	Metal binding	145	1	Zinc By similarity HAMAP MF_00124
	Metal binding	148	1	Zinc By similarity HAMAP MF_00124
	Metal binding	183	1	Zinc By similarity HAMAP MF_00124
	Metal binding	186	1	Zinc By similarity HAMAP MF_00124

Sequences

	Sequence		Length	Mass (Da)
	A6QIW3 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: C1EC76B7C5645909	FASTA	199	22,214
	10 20 30 40 50 60 MYETYHSGWI ECITGSMFSG KSEELIRRLR RGIYAKQKVV VFKPAIDDRY HKEKVVSHNG 70 80 90 100 110 120 NAIEAINISK ASEIMTHDLT NVDVIGIDEV QFFDDEIVSI VEKLSADGHR VIVAGLDMDF 130 140 150 160 170 180 RGEPFEPMPK LMAVSEQVTK LQAVCAVCGS SSSRTQRLIN GKPAKIDDPI ILVGANESYE 190 PRCRAHHIVA PSDNNKEEL

References

[1]

"Genome sequence of Staphylococcus aureus strain Newman and comparative analysis of staphylococcal genomes: polymorphism and evolution of two major pathogenicity islands." Baba T., Bae T., Schneewind O., Takeuchi F., Hiramatsu K. J. Bacteriol. 190:300-310(2008) [PubMed: 17951380] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009351 Genomic DNA. Translation: BAF68295.1.
RefSeq	YP_001333057.1. NC_009641.1.
3D structure databases
ProteinModelPortal	A6QIW3.
SMR	A6QIW3. Positions 1-189.
ModBase	Search...
Protein-protein interaction databases
STRING	A6QIW3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000031672; EBSTAP00000030542; EBSTAG00000031670.
GeneID	5332287.
GenomeReviews	Gene locus NWMN_2023 in contig AP009351_GR.
KEGG	sae:NWMN_2023.
PATRIC	19587848. VBIStaAur133992_2209.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1435.
GeneTree	EBGT00050000023861.
HOGENOM	HBG522108.
OMA	EPRCRHH.
ProtClustDB	PRK04296.
Enzyme and pathway databases
BioCyc	SAUR426430:NWMN_2023-MONOMER.
Family and domain databases
HAMAP	MF_00124. Thymidine_kinase. [Tree]
InterPro	IPR001267. Thymidine_kinase. IPR020633. Thymidine_kinase_CS. IPR020634. Thymidine_kinase_subgr. [Graphical view]
KO	K00857.
PANTHER	PTHR11441. TK_cell. 1 hit.
Pfam	PF00265. TK. 1 hit. [Graphical view]
PIRSF	PIRSF035805. TK_cell. 1 hit.
PROSITE	PS00603. TK_CELLULAR_TYPE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A6QIW3_STAAE

Accession

Primary (citable) accession number: A6QIW3

Entry history

Integrated into UniProtKB/TrEMBL:	August 21, 2007
Last sequence update:	August 21, 2007
Last modified:	December 14, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)