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A6QIT5

- THIE_STAAE

UniProt

A6QIT5 - THIE_STAAE

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Protein

Thiamine-phosphate synthase

Gene
thiE, NWMN_1995
Organism
Staphylococcus aureus (strain Newman)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) By similarity.UniRule annotation

Catalytic activityi

2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)thiazole = diphosphate + thiamine phosphate.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei75 – 751HMP-PP By similarity
Metal bindingi76 – 761Magnesium By similarity
Metal bindingi95 – 951Magnesium By similarity
Binding sitei113 – 1131HMP-PP By similarity
Binding sitei142 – 1421HMP-PP By similarity
Binding sitei171 – 1711THZ-P; via amide nitrogen By similarity

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. thiamine-phosphate diphosphorylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-HAMAP
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciSAUR426430:GIXC-2059-MONOMER.
UniPathwayiUPA00060; UER00141.

Names & Taxonomyi

Protein namesi
Recommended name:
Thiamine-phosphate synthase (EC:2.5.1.3)
Short name:
TP synthase
Short name:
TPS
Alternative name(s):
Thiamine-phosphate pyrophosphorylase
Short name:
TMP pyrophosphorylase
Short name:
TMP-PPase
Gene namesi
Name:thiE
Ordered Locus Names:NWMN_1995
OrganismiStaphylococcus aureus (strain Newman)
Taxonomic identifieri426430 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000006386: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 213213Thiamine-phosphate synthaseUniRule annotationPRO_1000071284Add
BLAST

Proteomic databases

PRIDEiA6QIT5.

Interactioni

Protein-protein interaction databases

STRINGi426430.NWMN_1995.

Structurei

3D structure databases

ProteinModelPortaliA6QIT5.
SMRiA6QIT5. Positions 4-209.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni40 – 445HMP-PP binding By similarity
Regioni139 – 1413THZ-P binding By similarity
Regioni191 – 1922THZ-P binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0352.
HOGENOMiHOG000155781.
KOiK00788.
OMAiQFREKGP.
OrthoDBiEOG6W19NW.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00097. TMP_synthase.
InterProiIPR013785. Aldolase_TIM.
IPR022998. ThiaminP_synth_SF.
IPR003733. TMP_synthase.
[Graphical view]
PfamiPF02581. TMP-TENI. 1 hit.
[Graphical view]
SUPFAMiSSF51391. SSF51391. 1 hit.
TIGRFAMsiTIGR00693. thiE. 1 hit.

Sequencei

Sequence statusi: Complete.

A6QIT5-1 [UniParc]FASTAAdd to Basket

« Hide

MFNQSYLNVY FICGTSDVPS HRTIHEVLEA ALKAGITLFQ FREKGESALK    50
GNDKLVLAKE LQHLCHQYDV PFIVNDDVSL AKEINADGIH VGQDDAKVKE 100
IAQYFTDKII GLSISDLDEY AKSDLTHVDY IGVGPIYPTP SKHDAHIPVG 150
PEMIATFKEM NPQLPIVAIG GINTNNVAPI VEAGANGISV ISAISKSENI 200
EKTVNRFKDF FNN 213
Length:213
Mass (Da):23,399
Last modified:August 21, 2007 - v1
Checksum:i8FEFB39D6EF82F94
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009351 Genomic DNA. Translation: BAF68267.1.
RefSeqiYP_001333029.1. NC_009641.1.

Genome annotation databases

EnsemblBacteriaiBAF68267; BAF68267; NWMN_1995.
GeneIDi5332232.
KEGGisae:NWMN_1995.
PATRICi19587794. VBIStaAur133992_2182.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009351 Genomic DNA. Translation: BAF68267.1 .
RefSeqi YP_001333029.1. NC_009641.1.

3D structure databases

ProteinModelPortali A6QIT5.
SMRi A6QIT5. Positions 4-209.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 426430.NWMN_1995.

Proteomic databases

PRIDEi A6QIT5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAF68267 ; BAF68267 ; NWMN_1995 .
GeneIDi 5332232.
KEGGi sae:NWMN_1995.
PATRICi 19587794. VBIStaAur133992_2182.

Phylogenomic databases

eggNOGi COG0352.
HOGENOMi HOG000155781.
KOi K00788.
OMAi QFREKGP.
OrthoDBi EOG6W19NW.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00141 .
BioCyci SAUR426430:GIXC-2059-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00097. TMP_synthase.
InterProi IPR013785. Aldolase_TIM.
IPR022998. ThiaminP_synth_SF.
IPR003733. TMP_synthase.
[Graphical view ]
Pfami PF02581. TMP-TENI. 1 hit.
[Graphical view ]
SUPFAMi SSF51391. SSF51391. 1 hit.
TIGRFAMsi TIGR00693. thiE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Staphylococcus aureus strain Newman and comparative analysis of staphylococcal genomes: polymorphism and evolution of two major pathogenicity islands."
    Baba T., Bae T., Schneewind O., Takeuchi F., Hiramatsu K.
    J. Bacteriol. 190:300-310(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Newman.

Entry informationi

Entry nameiTHIE_STAAE
AccessioniPrimary (citable) accession number: A6QIT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: August 21, 2007
Last modified: May 14, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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