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A6QIT5

- THIE_STAAE

UniProt

A6QIT5 - THIE_STAAE

Protein

Thiamine-phosphate synthase

Gene

thiE

Organism
Staphylococcus aureus (strain Newman)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).UniRule annotation

    Catalytic activityi

    2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)thiazole = diphosphate + thiamine phosphate.UniRule annotation

    Cofactori

    Binds 1 magnesium ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei75 – 751HMP-PPUniRule annotation
    Metal bindingi76 – 761MagnesiumUniRule annotation
    Metal bindingi95 – 951MagnesiumUniRule annotation
    Binding sitei113 – 1131HMP-PPUniRule annotation
    Binding sitei142 – 1421HMP-PPUniRule annotation
    Binding sitei171 – 1711THZ-P; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. thiamine-phosphate diphosphorylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. thiamine biosynthetic process Source: UniProtKB-HAMAP
    2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Thiamine biosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciSAUR426430:GIXC-2059-MONOMER.
    UniPathwayiUPA00060; UER00141.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thiamine-phosphate synthaseUniRule annotation (EC:2.5.1.3UniRule annotation)
    Short name:
    TP synthaseUniRule annotation
    Short name:
    TPSUniRule annotation
    Alternative name(s):
    Thiamine-phosphate pyrophosphorylaseUniRule annotation
    Short name:
    TMP pyrophosphorylaseUniRule annotation
    Short name:
    TMP-PPaseUniRule annotation
    Gene namesi
    Name:thiEUniRule annotation
    Ordered Locus Names:NWMN_1995
    OrganismiStaphylococcus aureus (strain Newman)
    Taxonomic identifieri426430 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000006386: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 213213Thiamine-phosphate synthasePRO_1000071284Add
    BLAST

    Proteomic databases

    PRIDEiA6QIT5.

    Interactioni

    Protein-protein interaction databases

    STRINGi426430.NWMN_1995.

    Structurei

    3D structure databases

    ProteinModelPortaliA6QIT5.
    SMRiA6QIT5. Positions 4-209.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni40 – 445HMP-PP bindingUniRule annotation
    Regioni139 – 1413THZ-P bindingUniRule annotation
    Regioni191 – 1922THZ-P bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the thiamine-phosphate synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0352.
    HOGENOMiHOG000155781.
    KOiK00788.
    OMAiQFREKGP.
    OrthoDBiEOG6W19NW.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00097. TMP_synthase.
    InterProiIPR013785. Aldolase_TIM.
    IPR022998. ThiaminP_synth_SF.
    IPR003733. TMP_synthase.
    [Graphical view]
    PfamiPF02581. TMP-TENI. 1 hit.
    [Graphical view]
    SUPFAMiSSF51391. SSF51391. 1 hit.
    TIGRFAMsiTIGR00693. thiE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A6QIT5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFNQSYLNVY FICGTSDVPS HRTIHEVLEA ALKAGITLFQ FREKGESALK    50
    GNDKLVLAKE LQHLCHQYDV PFIVNDDVSL AKEINADGIH VGQDDAKVKE 100
    IAQYFTDKII GLSISDLDEY AKSDLTHVDY IGVGPIYPTP SKHDAHIPVG 150
    PEMIATFKEM NPQLPIVAIG GINTNNVAPI VEAGANGISV ISAISKSENI 200
    EKTVNRFKDF FNN 213
    Length:213
    Mass (Da):23,399
    Last modified:August 21, 2007 - v1
    Checksum:i8FEFB39D6EF82F94
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009351 Genomic DNA. Translation: BAF68267.1.
    RefSeqiYP_001333029.1. NC_009641.1.

    Genome annotation databases

    EnsemblBacteriaiBAF68267; BAF68267; NWMN_1995.
    GeneIDi5332232.
    KEGGisae:NWMN_1995.
    PATRICi19587794. VBIStaAur133992_2182.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009351 Genomic DNA. Translation: BAF68267.1 .
    RefSeqi YP_001333029.1. NC_009641.1.

    3D structure databases

    ProteinModelPortali A6QIT5.
    SMRi A6QIT5. Positions 4-209.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 426430.NWMN_1995.

    Proteomic databases

    PRIDEi A6QIT5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAF68267 ; BAF68267 ; NWMN_1995 .
    GeneIDi 5332232.
    KEGGi sae:NWMN_1995.
    PATRICi 19587794. VBIStaAur133992_2182.

    Phylogenomic databases

    eggNOGi COG0352.
    HOGENOMi HOG000155781.
    KOi K00788.
    OMAi QFREKGP.
    OrthoDBi EOG6W19NW.

    Enzyme and pathway databases

    UniPathwayi UPA00060 ; UER00141 .
    BioCyci SAUR426430:GIXC-2059-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00097. TMP_synthase.
    InterProi IPR013785. Aldolase_TIM.
    IPR022998. ThiaminP_synth_SF.
    IPR003733. TMP_synthase.
    [Graphical view ]
    Pfami PF02581. TMP-TENI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51391. SSF51391. 1 hit.
    TIGRFAMsi TIGR00693. thiE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Staphylococcus aureus strain Newman and comparative analysis of staphylococcal genomes: polymorphism and evolution of two major pathogenicity islands."
      Baba T., Bae T., Schneewind O., Takeuchi F., Hiramatsu K.
      J. Bacteriol. 190:300-310(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Newman.

    Entry informationi

    Entry nameiTHIE_STAAE
    AccessioniPrimary (citable) accession number: A6QIT5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3