Skip Header

Contribute Send feedback
Read comments (?) or add your own

A6QIS6 (A6QIS6_STAAE) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase RuleBase RU004136
EC=6.3.2.10 RuleBase RU004136
Gene names
Name:murF EMBL BAF68258.1
Ordered Locus Names:NWMN_1986
OrganismStaphylococcus aureus (strain Newman) [Complete proteome] [HAMAP]
Taxonomic identifier426430 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Staphylococcus ›

Protein attributes

Sequence length452 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein By similarity.

Catalytic activity

ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the MurCDEF family. RuleBase RU003630

Sequences

Sequence LengthMass (Da)Tools
A6QIS6 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 3FA24089A2AEACCA

FASTA45250,053
        10         20         30         40         50         60 
MINVTLKQIQ SWIPCEIEDQ FLNQEINGVT IDSRAISKNM LFIPFKGENV DGHRFVSKAL 

        70         80         90        100        110        120 
QDGAGAAFYQ RGTPIDENVS GPIIWVEDTL TALQQLAQAY LRHVNPKVIA VTGSNGKTTT 

       130        140        150        160        170        180 
KDMIESVLHT EFKVKKTQGN YNNEIGLPLT ILELDNDTEI SILEMGMSGF HEIEFLSNLA 

       190        200        210        220        230        240 
QPDIAVITNI GESHMQDLGS REGIAKAKSE ITIGLKDNGT FIYDGDEPLL KPHVKEVENA 

       250        260        270        280        290        300 
KCISIGVATD NALVCSVDDR DTTGISFTIN NKEHYDLPIL GKHNMKNATI AIAVGHELGL 

       310        320        330        340        350        360 
TYNTIYQNLK NVSLTGMRME QHTLENDITV INDAYNASPT SMRAAIDTLS TLTGRRILIL 

       370        380        390        400        410        420 
GDVLELGENS KEMHIGVGNY LEEKHIDVLY TFGNEAKYIY DSGQQHVEKA QHFNSKDDMI 

       430        440        450 
EVLINDLKAH DRVLVKGSRG MKLEEVVNAL IS

« Hide

References

[1]"Genome sequence of Staphylococcus aureus strain Newman and comparative analysis of staphylococcal genomes: polymorphism and evolution of two major pathogenicity islands."
Baba T., Bae T., Schneewind O., Takeuchi F., Hiramatsu K.
J. Bacteriol. 190:300-310(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Newman.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP009351 Genomic DNA. Translation: BAF68258.1.
RefSeqYP_001333020.1. NC_009641.1.

3D structure databases

ProteinModelPortalA6QIS6.
SMRA6QIS6. Positions 21-450.
ModBaseSearch...

Protein-protein interaction databases

STRING426430.NWMN_1986.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAF68258; BAF68258; NWMN_1986.
GeneID5331218.
KEGGsae:NWMN_1986.
PATRIC19587776. VBIStaAur133992_2173.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0770.
HOGENOMHOG000268119.
KOK01929.
OMAGNRNNEI.
ProtClustDBCLSK885754.

Enzyme and pathway databases

BioCycSAUR426430:GIXC-1987-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.40.1190.10. 1 hit.
3.90.190.20. 1 hit.
InterProIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR005863. UDP-N-AcMur-pentapeptide_synth.
[Graphical view]
PANTHERPTHR23135:SF3. PTHR23135:SF3. 1 hit.
PfamPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMSSF53244. Mur_ligase_C. 1 hit.
SSF53623. Mur_ligase_cen. 1 hit.
TIGRFAMsTIGR01143. murF. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA6QIS6_STAAE
AccessionPrimary (citable) accession number: A6QIS6
Entry history
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: May 1, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info