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Protein

Monofunctional glycosyltransferase

Gene

mgt

Organism
Staphylococcus aureus (strain Newman)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Peptidoglycan polymerase that catalyzes glycan chain elongation using lipid-linked disaccharide-pentapeptide as the substrate.UniRule annotation

Catalytic activityi

(GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n)-diphosphoundecaprenol + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = (GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n+1)-diphosphoundecaprenol + undecaprenyl diphosphate.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219

Protein family/group databases

CAZyiGT51 Glycosyltransferase Family 51

Names & Taxonomyi

Protein namesi
Recommended name:
Monofunctional glycosyltransferaseUniRule annotation (EC:2.4.1.129UniRule annotation)
Short name:
MGTUniRule annotation
Alternative name(s):
Peptidoglycan TGaseUniRule annotation
Gene namesi
Name:mgtUniRule annotation
Ordered Locus Names:NWMN_1766
OrganismiStaphylococcus aureus (strain Newman)
Taxonomic identifieri426430 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000006386 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Single-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei46 – 66HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000735121 – 269Monofunctional glycosyltransferaseAdd BLAST269

Structurei

3D structure databases

ProteinModelPortaliA6QI56
SMRiA6QI56
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 51 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000288116
KOiK04478
OMAiPAPKCFD

Family and domain databases

Gene3Di1.10.3810.10, 1 hit
HAMAPiMF_01434 MGT, 1 hit
InterProiView protein in InterPro
IPR001264 Glyco_trans_51
IPR023346 Lysozyme-like_dom_sf
IPR022978 Monofunct_glyco_trans
IPR036950 PBP_transglycosylase
PfamiView protein in Pfam
PF00912 Transgly, 1 hit
SUPFAMiSSF53955 SSF53955, 1 hit

Sequencei

Sequence statusi: Complete.

A6QI56-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRSDRYSNS NEHFEHMKHE PHYNTYYQPV GKPPKKKKSK RILLKILLTI
60 70 80 90 100
LIIIALFIGI MYFLSTRDNV DELRKIENKS SFVSADNMPE YVKGAFISME
110 120 130 140 150
DERFYNHHGF DLKGTTRALF STISDRDVQG GSTITQQVVK NYFYDNDRSF
160 170 180 190 200
TRKVKELFVA HRVEKQYNKN EILSFYLNNI YFGDNQYTLE GAANHYFGTT
210 220 230 240 250
VNKNSTTMSH ITVLQSAILA SKVNAPSVYN INNMSENFTQ RVSTNLEKMK
260
QQNYINETQY QQAMSQLNR
Length:269
Mass (Da):31,460
Last modified:August 21, 2007 - v1
Checksum:iC0F65B9F5CAB8761
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009351 Genomic DNA Translation: BAF68038.1
RefSeqiWP_000830380.1, NZ_CP023390.1

Genome annotation databases

EnsemblBacteriaiBAF68038; BAF68038; NWMN_1766
KEGGisae:NWMN_1766

Similar proteinsi

Entry informationi

Entry nameiMGT_STAAE
AccessioniPrimary (citable) accession number: A6QI56
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: August 21, 2007
Last modified: March 28, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health