A6QI56 (MGT_STAAE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Monofunctional glycosyltransferase
Short name=MGT
EC=2.4.-.-

Alternative name(s):
Peptidoglycan TGase

Gene names

Name:	mgt
Ordered Locus Names:	NWMN_1766

Organism

Staphylococcus aureus (strain Newman) [Complete proteome] [HAMAP]

Taxonomic identifier

426430 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › Staphylococcus aureus subsp. aureus

Protein attributes

Sequence length	269 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the biosynthesis of cell wall peptidoglycan. Responsible for the elongation of the glycan strands using lipid-linked disaccharide-pentapeptide as the substrate By similarity. HAMAP-Rule MF_01434
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_01434
Subcellular location	Cell membrane; Single-pass membrane protein By similarity HAMAP-Rule MF_01434.
Sequence similarities	Belongs to the glycosyltransferase 51 family.

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan-based cell wall Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	transferase activity, transferring glycosyl groups Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 269	269	Monofunctional glycosyltransferase HAMAP-Rule MF_01434		PRO_1000073512
Regions
	Transmembrane	46 – 66	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	A6QI56 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: C0F65B9F5CAB8761	FASTA	269	31,460
	10 20 30 40 50 60 MKRSDRYSNS NEHFEHMKHE PHYNTYYQPV GKPPKKKKSK RILLKILLTI LIIIALFIGI 70 80 90 100 110 120 MYFLSTRDNV DELRKIENKS SFVSADNMPE YVKGAFISME DERFYNHHGF DLKGTTRALF 130 140 150 160 170 180 STISDRDVQG GSTITQQVVK NYFYDNDRSF TRKVKELFVA HRVEKQYNKN EILSFYLNNI 190 200 210 220 230 240 YFGDNQYTLE GAANHYFGTT VNKNSTTMSH ITVLQSAILA SKVNAPSVYN INNMSENFTQ 250 260 RVSTNLEKMK QQNYINETQY QQAMSQLNR

References

[1]

"Genome sequence of Staphylococcus aureus strain Newman and comparative analysis of staphylococcal genomes: polymorphism and evolution of two major pathogenicity islands." Baba T., Bae T., Schneewind O., Takeuchi F., Hiramatsu K. J. Bacteriol. 190:300-310(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Newman.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009351 Genomic DNA. Translation: BAF68038.1.
RefSeq	YP_001332800.1. NC_009641.1.
3D structure databases
ProteinModelPortal	A6QI56.
SMR	A6QI56. Positions 61-269.
ModBase	Search...
Protein-protein interaction databases
STRING	426430.NWMN_1766.
Protein family/group databases
CAZy	GT51. Glycosyltransferase Family 51.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAF68038; BAF68038; NWMN_1766.
GeneID	5331053.
KEGG	sae:NWMN_1766.
PATRIC	19587238. VBIStaAur133992_1908.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0744.
HOGENOM	HOG000288116.
KO	K04478.
OMA	YISHDEY.
ProtClustDB	PRK13481.
Enzyme and pathway databases
BioCyc	SAUR426430:GIXC-1767-MONOMER.
UniPathway	UPA00219.
Family and domain databases
HAMAP	MF_01434. MGT.
InterPro	IPR001264. Glyco_trans_51. IPR022978. Monofunct_glyco_trans. [Graphical view]
Pfam	PF00912. Transgly. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MGT_STAAE

Accession

Primary (citable) accession number: A6QI56

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	August 21, 2007
Last modified:	May 1, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program