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A6QHV6

- ARSC_STAAE

UniProt

A6QHV6 - ARSC_STAAE

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Protein

Protein ArsC

Gene

arsC

Organism
Staphylococcus aureus (strain Newman)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances.UniRule annotation

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotation
Arsenate + thioredoxin = arsenite + thioredoxin disulfide + H2O.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei10 – 101Nucleophile; for reductase activity and phosphatase activityUniRule annotation
Active sitei82 – 821Nucleophile; for reductase activityUniRule annotation
Active sitei89 – 891Nucleophile; for reductase activityUniRule annotation

GO - Molecular functioni

  1. arsenate reductase (thioredoxin) activity Source: UniProtKB-HAMAP
  2. protein tyrosine phosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. response to arsenic-containing substance Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Oxidoreductase

Keywords - Biological processi

Arsenical resistance

Enzyme and pathway databases

BioCyciSAUR426430:GIXC-1689-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ArsCUniRule annotation
Alternative name(s):
Arsenate reductaseUniRule annotation (EC:1.20.4.-UniRule annotation)
Arsenical pump modifierUniRule annotation
Low molecular weight protein-tyrosine-phosphataseUniRule annotation (EC:3.1.3.48UniRule annotation)
Gene namesi
Name:arsCUniRule annotation
Ordered Locus Names:NWMN_1666
OrganismiStaphylococcus aureus (strain Newman)
Taxonomic identifieri426430 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000006386: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 131131Protein ArsCPRO_1000073637Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi10 ↔ 82Redox-active; alternateUniRule annotation
Disulfide bondi82 ↔ 89Redox-active; alternateUniRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi426430.NWMN_1666.

Structurei

3D structure databases

ProteinModelPortaliA6QHV6.
SMRiA6QHV6. Positions 3-131.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the low molecular weight phosphotyrosine protein phosphatase superfamily. ArsC family.UniRule annotation

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiCOG0394.
HOGENOMiHOG000273093.
KOiK03741.
OMAiEMRIVIT.
OrthoDBiEOG6JDWJC.

Family and domain databases

HAMAPiMF_01624. Arsenate_reduct.
InterProiIPR014064. Arsenate_reductase_ArsC.
IPR023485. Ptyr_pPase_SF.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERiPTHR11717:SF18. PTHR11717:SF18. 1 hit.
PfamiPF01451. LMWPc. 1 hit.
[Graphical view]
SMARTiSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMiSSF52788. SSF52788. 1 hit.
TIGRFAMsiTIGR02691. arsC_pI258_fam. 1 hit.

Sequencei

Sequence statusi: Complete.

A6QHV6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKKTIYFIC TGNSCRSQMA EGWAKQILAD DWNVYSAGIE THGVNPKAIE
60 70 80 90 100
AMKEVGIDIS NHTSDLIDNN IIKNSNLVVT LCSDADVNCP SLPTNVKKEH
110 120 130
WGFDDPAGKP WSEFQRVRDE IKIAIENFKS R
Length:131
Mass (Da):14,687
Last modified:August 21, 2007 - v1
Checksum:i9B6AA5A854D66C89
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009351 Genomic DNA. Translation: BAF67938.1.
RefSeqiYP_001332700.1. NC_009641.1.

Genome annotation databases

EnsemblBacteriaiBAF67938; BAF67938; NWMN_1666.
GeneIDi5330984.
KEGGisae:NWMN_1666.
PATRICi19586947. VBIStaAur133992_1802.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009351 Genomic DNA. Translation: BAF67938.1 .
RefSeqi YP_001332700.1. NC_009641.1.

3D structure databases

ProteinModelPortali A6QHV6.
SMRi A6QHV6. Positions 3-131.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 426430.NWMN_1666.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAF67938 ; BAF67938 ; NWMN_1666 .
GeneIDi 5330984.
KEGGi sae:NWMN_1666.
PATRICi 19586947. VBIStaAur133992_1802.

Phylogenomic databases

eggNOGi COG0394.
HOGENOMi HOG000273093.
KOi K03741.
OMAi EMRIVIT.
OrthoDBi EOG6JDWJC.

Enzyme and pathway databases

BioCyci SAUR426430:GIXC-1689-MONOMER.

Family and domain databases

HAMAPi MF_01624. Arsenate_reduct.
InterProi IPR014064. Arsenate_reductase_ArsC.
IPR023485. Ptyr_pPase_SF.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view ]
PANTHERi PTHR11717:SF18. PTHR11717:SF18. 1 hit.
Pfami PF01451. LMWPc. 1 hit.
[Graphical view ]
SMARTi SM00226. LMWPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52788. SSF52788. 1 hit.
TIGRFAMsi TIGR02691. arsC_pI258_fam. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Staphylococcus aureus strain Newman and comparative analysis of staphylococcal genomes: polymorphism and evolution of two major pathogenicity islands."
    Baba T., Bae T., Schneewind O., Takeuchi F., Hiramatsu K.
    J. Bacteriol. 190:300-310(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Newman.

Entry informationi

Entry nameiARSC_STAAE
AccessioniPrimary (citable) accession number: A6QHV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: August 21, 2007
Last modified: October 29, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3