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Protein

Peptide methionine sulfoxide reductase MsrB

Gene

msrB

Organism
Staphylococcus aureus (strain Newman)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei114 – 1141NucleophilePROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciSAUR426430:GIXC-1357-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide methionine sulfoxide reductase MsrBUniRule annotation (EC:1.8.4.12UniRule annotation)
Alternative name(s):
Peptide-methionine (R)-S-oxide reductaseUniRule annotation
Gene namesi
Name:msrBUniRule annotation
Ordered Locus Names:NWMN_1334
OrganismiStaphylococcus aureus (strain Newman)
Taxonomic identifieri426430 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000006386 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 142142Peptide methionine sulfoxide reductase MsrBPRO_1000073496Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA6QGX4.
SMRiA6QGX4. Positions 9-142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 125124MsrBPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MsrB Met sulfoxide reductase family.UniRule annotation
Contains 1 MsrB (methionine-R-sulfoxide reductase) domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000243425.
KOiK07305.
OMAiRMQYEVT.
OrthoDBiEOG6091JX.

Family and domain databases

Gene3Di2.170.150.20. 1 hit.
HAMAPiMF_01400. MsrB.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002579. Met_Sox_Rdtase_MsrB.
IPR011057. Mss4-like.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01641. SelR. 1 hit.
[Graphical view]
SUPFAMiSSF51316. SSF51316. 1 hit.
TIGRFAMsiTIGR00357. TIGR00357. 1 hit.
PROSITEiPS51790. MSRB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6QGX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKKDKSELT DIEYIVTQEN GTEPPFMNEY WNHFAKGIYV DKISGKPLFT
60 70 80 90 100
SEEKFHSECG WPSFSKALDD DEIIELVDKS FGMLRTEVRS EESNSHLGHV
110 120 130 140
FNDGPKESGG LRYCINSAAI QFIPYEKLEE LGYGDLISHF DK
Length:142
Mass (Da):16,277
Last modified:August 21, 2007 - v1
Checksum:i8B8DD1390D9F80AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009351 Genomic DNA. Translation: BAF67606.1.
RefSeqiWP_000913315.1. NC_009641.1.

Genome annotation databases

EnsemblBacteriaiBAF67606; BAF67606; NWMN_1334.
KEGGisae:NWMN_1334.
PATRICi19586247. VBIStaAur133992_1451.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009351 Genomic DNA. Translation: BAF67606.1.
RefSeqiWP_000913315.1. NC_009641.1.

3D structure databases

ProteinModelPortaliA6QGX4.
SMRiA6QGX4. Positions 9-142.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAF67606; BAF67606; NWMN_1334.
KEGGisae:NWMN_1334.
PATRICi19586247. VBIStaAur133992_1451.

Phylogenomic databases

HOGENOMiHOG000243425.
KOiK07305.
OMAiRMQYEVT.
OrthoDBiEOG6091JX.

Enzyme and pathway databases

BioCyciSAUR426430:GIXC-1357-MONOMER.

Family and domain databases

Gene3Di2.170.150.20. 1 hit.
HAMAPiMF_01400. MsrB.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002579. Met_Sox_Rdtase_MsrB.
IPR011057. Mss4-like.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01641. SelR. 1 hit.
[Graphical view]
SUPFAMiSSF51316. SSF51316. 1 hit.
TIGRFAMsiTIGR00357. TIGR00357. 1 hit.
PROSITEiPS51790. MSRB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Staphylococcus aureus strain Newman and comparative analysis of staphylococcal genomes: polymorphism and evolution of two major pathogenicity islands."
    Baba T., Bae T., Schneewind O., Takeuchi F., Hiramatsu K.
    J. Bacteriol. 190:300-310(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Newman.

Entry informationi

Entry nameiMSRB_STAAE
AccessioniPrimary (citable) accession number: A6QGX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: August 21, 2007
Last modified: June 8, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.