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A6QEL9

- GCH4_STAAE

UniProt

A6QEL9 - GCH4_STAAE

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Staphylococcus aureus (strain Newman)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei176 – 1761May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciSAUR426430:GIXC-547-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:NWMN_0529
    OrganismiStaphylococcus aureus (strain Newman)
    Taxonomic identifieri426430 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000006386: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 292292GTP cyclohydrolase FolE2PRO_1000073546Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi426430.NWMN_0529.

    Structurei

    3D structure databases

    ProteinModelPortaliA6QEL9.
    SMRiA6QEL9. Positions 47-290.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000280679.
    KOiK09007.
    OMAiAKWFFDR.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A6QEL9-1 [UniParc]FASTAAdd to Basket

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    MTEFDLSTRE GRWKHFGSVD PIEGTKPTTK NEMTDLQSTH KDFLFEIEEV    50
    GIKNLVYPVL VDQYQTAGTF SFSTSLTKDE KGINMSRIIE SVEKHYDNGI 100
    ELEFNTLYQV LRTLQTNMKQ NAAGVDVSGK WFFDRYSPTT NIKAVGNADV 150
    TYGLAIDGDK VTRKELTIEA TVTTLCPCSK EISEYSAHNQ RGVVTVKTYI 200
    NKDQDIVDDY KNKILDAMEA NASSILYPIL KRPDEKRVTE RAYENPRFVE 250
    DLIRLIAADL VEFDWLDGFD IECRNEESIH QHDAFAKLKY RK 292
    Length:292
    Mass (Da):33,482
    Last modified:August 21, 2007 - v1
    Checksum:i22E051A090E85536
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009351 Genomic DNA. Translation: BAF66801.1.
    RefSeqiYP_001331563.1. NC_009641.1.

    Genome annotation databases

    EnsemblBacteriaiBAF66801; BAF66801; NWMN_0529.
    GeneIDi5330278.
    KEGGisae:NWMN_0529.
    PATRICi19584500. VBIStaAur133992_0576.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009351 Genomic DNA. Translation: BAF66801.1 .
    RefSeqi YP_001331563.1. NC_009641.1.

    3D structure databases

    ProteinModelPortali A6QEL9.
    SMRi A6QEL9. Positions 47-290.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 426430.NWMN_0529.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAF66801 ; BAF66801 ; NWMN_0529 .
    GeneIDi 5330278.
    KEGGi sae:NWMN_0529.
    PATRICi 19584500. VBIStaAur133992_0576.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000280679.
    KOi K09007.
    OMAi AKWFFDR.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci SAUR426430:GIXC-547-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00294. TIGR00294. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Staphylococcus aureus strain Newman and comparative analysis of staphylococcal genomes: polymorphism and evolution of two major pathogenicity islands."
      Baba T., Bae T., Schneewind O., Takeuchi F., Hiramatsu K.
      J. Bacteriol. 190:300-310(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Newman.

    Entry informationi

    Entry nameiGCH4_STAAE
    AccessioniPrimary (citable) accession number: A6QEL9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3