A6QBY0 (FABH_SULNB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3
EC=2.3.1.180

Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III
Beta-ketoacyl-ACP synthase III
Short name=KAS III

Gene names

Name:	fabH
Ordered Locus Names:	SUN_2048

Organism

Sulfurovum sp. (strain NBC37-1) [Complete proteome] [HAMAP]

Taxonomic identifier

387093 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Sulfurovum

Protein attributes

Sequence length	340 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815
Catalytic activity	Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815
Pathway	Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815
Subunit structure	Homodimer By similarity. HAMAP MF_01815
Subcellular location	Cytoplasm By similarity HAMAP MF_01815.
Domain	The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815
Sequence similarities	Belongs to the FabH family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Cytoplasm
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Multifunctional enzyme
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-oxoacyl-[acyl-carrier-protein] synthase activity Inferred from electronic annotation. Source: InterPro beta-ketoacyl-acyl-carrier-protein synthase III activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 340	340	3-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP MF_01815		PRO_1000187907
Regions
	Region	261 – 265	5	ACP-binding By similarity
Sites
	Active site	119	1	By similarity
	Active site	260	1	By similarity
	Active site	290	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6QBY0 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 4BB846934257585F	FASTA	340	36,666
	10 20 30 40 50 60 MSQTKPVYAS FRSIGAYVPS KILSNADLEK MVDTTDEWIV KRTGIKERHI AADDEYTSDM 70 80 90 100 110 120 GAKAAKLAIE RAGIEKEDID LVLCATVTPD YFNMPSTACI ISDKLGIRNV QAFDISAACS 130 140 150 160 170 180 GFVYLLTVAK AFIESGMKKN VLIIGAEKFS SVVDYTDRST CILFGDGAGA AIISATDKKE 190 200 210 220 230 240 EGFIDVHASA DGSYADFLVT PAPGAINPAS QKVIDEGLNF VQMKGNETFK LAVKTLTKDV 250 260 270 280 290 300 KEILAKNKID SGDIPHFIPH QANYRIIKAV GDALKMREDQ VVLTVGKYGN TSAASIPMAI 310 320 330 340 NEIWESGRLK TGDLMLLDTF GGGLTWASAL LPFAGESVQR

References

[1]

"Deep-sea vent epsilon-proteobacterial genomes provide insights into emergence of pathogens." Nakagawa S., Takaki Y., Shimamura S., Reysenbach A.-L., Takai K., Horikoshi K. Proc. Natl. Acad. Sci. U.S.A. 104:12146-12150(2007) [PubMed: 17615243] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NBC37-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009179 Genomic DNA. Translation: BAF72989.1.
RefSeq	YP_001359346.1. NC_009663.1.
3D structure databases
ProteinModelPortal	A6QBY0.
ModBase	Search...
Protein-protein interaction databases
STRING	A6QBY0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5362619.
GenomeReviews	Gene locus SUN_2048 in contig AP009179_GR.
KEGG	sun:SUN_2048.
NMPDR	fig|387093.4.peg.1975.
PATRIC	23777155. VBISulSp49917_2088.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0332.
HOGENOM	HBG649927.
OMA	DAYIRGG.
ProtClustDB	PRK09352.
Enzyme and pathway databases
BioCyc	SSP387093:SUN_2048-MONOMER.
Family and domain databases
HAMAP	MF_01815. FabH. [Tree]
InterPro	IPR013751. ACP_syn_III. IPR013747. ACP_syn_III_C. IPR004655. FabH_synth. IPR016039. Thiolase-like. IPR016038. Thiolase-like_subgr. [Graphical view]
Gene3D	G3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KO	K00648.
Pfam	PF08545. ACP_syn_III. 1 hit. PF08541. ACP_syn_III_C. 1 hit. [Graphical view]
SUPFAM	SSF53901. Thiolase-like. 1 hit.
TIGRFAMs	TIGR00747. FabH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FABH_SULNB

Accession

Primary (citable) accession number: A6QBY0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	August 21, 2007
Last modified:	December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program