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Protein

Glutamate 5-kinase

Gene

proB

Organism
Sulfurovum sp. (strain NBC37-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.UniRule annotation

Catalytic activityi

ATP + L-glutamate = ADP + L-glutamate 5-phosphate.UniRule annotation

Pathwayi: L-proline biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamate 5-kinase (proB)
  2. Gamma-glutamyl phosphate reductase (proA)
This subpathway is part of the pathway L-proline biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei7ATPUniRule annotation1
Binding sitei46SubstrateUniRule annotation1
Binding sitei131SubstrateUniRule annotation1
Binding sitei143Substrate; via amide nitrogenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi163 – 164ATPUniRule annotation2
Nucleotide bindingi205 – 211ATPUniRule annotation7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processAmino-acid biosynthesis, Proline biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSP387093:G1G2P-1843-MONOMER
UniPathwayiUPA00098; UER00359

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate 5-kinaseUniRule annotation (EC:2.7.2.11UniRule annotation)
Alternative name(s):
Gamma-glutamyl kinaseUniRule annotation
Short name:
GKUniRule annotation
Gene namesi
Name:proBUniRule annotation
Ordered Locus Names:SUN_1781
OrganismiSulfurovum sp. (strain NBC37-1)
Taxonomic identifieri387093 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaSulfurovum
Proteomesi
  • UP000006378 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000811161 – 257Glutamate 5-kinaseAdd BLAST257

Interactioni

Protein-protein interaction databases

STRINGi387093.SUN_1781

Structurei

3D structure databases

ProteinModelPortaliA6QB69
SMRiA6QB69
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamate 5-kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CGT Bacteria
COG0263 LUCA
HOGENOMiHOG000246368
KOiK00931
OMAiADDFDSR
OrthoDBiPOG091H00OF

Family and domain databases

Gene3Di3.40.1160.10, 1 hit
HAMAPiMF_00456 ProB, 1 hit
InterProiView protein in InterPro
IPR036393 AceGlu_kinase-like_sf
IPR001048 Asp/Glu/Uridylate_kinase
IPR001057 Glu/AcGlu_kinase
IPR011529 Glu_5kinase
IPR005715 Glu_5kinase/COase_Synthase
IPR019797 Glutamate_5-kinase_CS
PfamiView protein in Pfam
PF00696 AA_kinase, 1 hit
PIRSFiPIRSF000729 GK, 1 hit
PRINTSiPR00474 GLU5KINASE
SUPFAMiSSF53633 SSF53633, 1 hit
TIGRFAMsiTIGR01027 proB, 1 hit
PROSITEiView protein in PROSITE
PS00902 GLUTAMATE_5_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

A6QB69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRIVIKVGS HVLTEDGSIA RERMMALVEL IADLKKHSYE VALVSSGAVA
60 70 80 90 100
AGYTQLPLDR DDIANRQALA AIGQPLLLKM YQEKFARFDL LCSQVLFSAD
110 120 130 140 150
VFESDKHVSH AKVAIDTLLA NNVVPIINEN DTVSIEELVF GDNDRLSAHV
160 170 180 190 200
AHYFDADLLV ILSDIDALYD KDPNCFQDAR RRAVVNEIEE EELAAEHTPN
210 220 230 240 250
NEFATGGIVT KLQAADFLMK HGREMFLASG FELSDVKSFL IEGEHKGGTL

FTSTKRS
Length:257
Mass (Da):28,450
Last modified:August 21, 2007 - v1
Checksum:i23BDF2CBB0E4DDE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009179 Genomic DNA Translation: BAF72728.1
RefSeqiWP_012083538.1, NC_009663.1

Genome annotation databases

EnsemblBacteriaiBAF72728; BAF72728; SUN_1781
KEGGisun:SUN_1781

Similar proteinsi

Entry informationi

Entry nameiPROB_SULNB
AccessioniPrimary (citable) accession number: A6QB69
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 21, 2007
Last modified: March 28, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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