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A6QAX6

- ASSY_SULNB

UniProt

A6QAX6 - ASSY_SULNB

Protein

Argininosuccinate synthase

Gene

argG

Organism
Sulfurovum sp. (strain NBC37-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei39 – 391ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
    Binding sitei92 – 921CitrullineUniRule annotation
    Binding sitei97 – 971CitrullineUniRule annotation
    Binding sitei122 – 1221ATP; via amide nitrogenUniRule annotation
    Binding sitei124 – 1241AspartateUniRule annotation
    Binding sitei128 – 1281AspartateUniRule annotation
    Binding sitei128 – 1281CitrullineUniRule annotation
    Binding sitei129 – 1291AspartateUniRule annotation
    Binding sitei132 – 1321CitrullineUniRule annotation
    Binding sitei182 – 1821CitrullineUniRule annotation
    Binding sitei191 – 1911CitrullineUniRule annotation
    Binding sitei267 – 2671CitrullineUniRule annotation
    Binding sitei279 – 2791CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 209ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSSP387093:GH25-1708-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotation
    Ordered Locus Names:SUN_1685
    OrganismiSulfurovum sp. (strain NBC37-1)
    Taxonomic identifieri387093 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaSulfurovum
    ProteomesiUP000006378: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 447447Argininosuccinate synthasePRO_0000329473Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi387093.SUN_1685.

    Structurei

    3D structure databases

    ProteinModelPortaliA6QAX6.
    SMRiA6QAX6. Positions 8-396.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230093.
    KOiK01940.
    OMAiAPPEEAY.
    OrthoDBiEOG6K9QCV.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6QAX6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKRKISKAV LAYSGGLDTS IILKWLQDEY ECEVVTFTAD LGQGEEVEPA    50
    RQKALDMGIK PENIFILDLR EEFVRDFVFP MFRANAIYEG EYLLGTSIAR 100
    PLISKKQIEI AHQTGADAVS HGATGKGNDQ VRFELGYLAL DPDIAVIAPW 150
    REWDLNSRTK LLAYAQEHGI NIDNKGKPKP YSMDANLLHI SYEGEHLENP 200
    YAEPEEDMWL WSVSPENAPD EPEYITISYK NGDPIAINRE EMSPATILET 250
    LNTYGKKHGI GRIDIVENRM VGMKARGCYE TPGGTIMLKA HRAIESITLD 300
    REEAHMKDEL MPKYAKLIYN GMWWSPERKM LQAAIDATQE NVEGTVKLKL 350
    YKGNVIVVGR KSEVSLYSEE HSTFEADDVY NQKDAEGFIR LNALRFIIEG 400
    KKQPERIKSL IGDYEETEVC RIETGSITIC ERIKRFFGFG KKTDKNA 447
    Length:447
    Mass (Da):50,701
    Last modified:August 21, 2007 - v1
    Checksum:i17C3195D84789EBB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009179 Genomic DNA. Translation: BAF72635.1.
    RefSeqiWP_012083445.1. NC_009663.1.
    YP_001358992.1. NC_009663.1.

    Genome annotation databases

    EnsemblBacteriaiBAF72635; BAF72635; SUN_1685.
    GeneIDi5363374.
    KEGGisun:SUN_1685.
    PATRICi23776379. VBISulSp49917_1710.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009179 Genomic DNA. Translation: BAF72635.1 .
    RefSeqi WP_012083445.1. NC_009663.1.
    YP_001358992.1. NC_009663.1.

    3D structure databases

    ProteinModelPortali A6QAX6.
    SMRi A6QAX6. Positions 8-396.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 387093.SUN_1685.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAF72635 ; BAF72635 ; SUN_1685 .
    GeneIDi 5363374.
    KEGGi sun:SUN_1685.
    PATRICi 23776379. VBISulSp49917_1710.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230093.
    KOi K01940.
    OMAi APPEEAY.
    OrthoDBi EOG6K9QCV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci SSP387093:GH25-1708-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Deep-sea vent epsilon-proteobacterial genomes provide insights into emergence of pathogens."
      Nakagawa S., Takaki Y., Shimamura S., Reysenbach A.-L., Takai K., Horikoshi K.
      Proc. Natl. Acad. Sci. U.S.A. 104:12146-12150(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NBC37-1.

    Entry informationi

    Entry nameiASSY_SULNB
    AccessioniPrimary (citable) accession number: A6QAX6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3