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A6QA78 (UPPP_SULNB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:SUN_1436
OrganismSulfurovum sp. (strain NBC37-1) [Complete proteome] [HAMAP]
Taxonomic identifier387093 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaSulfurovum

Protein attributes

Sequence length254 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 254254Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000062818

Regions

Transmembrane1 – 2121Helical; Potential
Transmembrane41 – 6121Helical; Potential
Transmembrane70 – 9021Helical; Potential
Transmembrane97 – 11721Helical; Potential
Transmembrane134 – 15421Helical; Potential
Transmembrane175 – 19521Helical; Potential
Transmembrane209 – 22921Helical; Potential
Transmembrane234 – 25421Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A6QA78 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 9074C90482989C76

FASTA25428,689
        10         20         30         40         50         60 
MDIIQAIIIG IIEGFTEFLP ISSTGHMIVA SKFLGVAETD LTKAYEVIIQ FAAILAVMLI 

        70         80         90        100        110        120 
YREKITFKKI DLWMKLLFAF LPLAIVGFIF KDQVKALFNV QVVAWMFIIG GIIFLIVEYY 

       130        140        150        160        170        180 
YKEQAWHVKD VEKVSWTQAW WVGFAQIFSL IPGTSRAGAT IIGGLLAGLD RKTSAEFSFL 

       190        200        210        220        230        240 
LAIPVMAVVS GYDLLKHYQD FADANWGAFL IGFIVAFIVA YATIKLFLVF LQRFTFVAFG 

       250 
IYRIIFGIFL LMIL 

« Hide

References

[1]"Deep-sea vent epsilon-proteobacterial genomes provide insights into emergence of pathogens."
Nakagawa S., Takaki Y., Shimamura S., Reysenbach A.-L., Takai K., Horikoshi K.
Proc. Natl. Acad. Sci. U.S.A. 104:12146-12150(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NBC37-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP009179 Genomic DNA. Translation: BAF72387.1.
RefSeqYP_001358744.1. NC_009663.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING387093.SUN_1436.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAF72387; BAF72387; SUN_1436.
GeneID5362912.
KEGGsun:SUN_1436.
PATRIC23775877. VBISulSp49917_1462.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAFNDAHAK.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycSSP387093:GH25-1456-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_SULNB
AccessionPrimary (citable) accession number: A6QA78
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 21, 2007
Last modified: May 14, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families