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A6QA78

- UPPP_SULNB

UniProt

A6QA78 - UPPP_SULNB

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Sulfurovum sp. (strain NBC37-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciSSP387093:GH25-1456-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:SUN_1436
    OrganismiSulfurovum sp. (strain NBC37-1)
    Taxonomic identifieri387093 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaSulfurovum
    ProteomesiUP000006378: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 254254Undecaprenyl-diphosphatasePRO_1000062818Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi387093.SUN_1436.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121HelicalUniRule annotationAdd
    BLAST
    Transmembranei41 – 6121HelicalUniRule annotationAdd
    BLAST
    Transmembranei70 – 9021HelicalUniRule annotationAdd
    BLAST
    Transmembranei97 – 11721HelicalUniRule annotationAdd
    BLAST
    Transmembranei134 – 15421HelicalUniRule annotationAdd
    BLAST
    Transmembranei175 – 19521HelicalUniRule annotationAdd
    BLAST
    Transmembranei209 – 22921HelicalUniRule annotationAdd
    BLAST
    Transmembranei234 – 25421HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218356.
    KOiK06153.
    OMAiFNDAHAK.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6QA78-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDIIQAIIIG IIEGFTEFLP ISSTGHMIVA SKFLGVAETD LTKAYEVIIQ    50
    FAAILAVMLI YREKITFKKI DLWMKLLFAF LPLAIVGFIF KDQVKALFNV 100
    QVVAWMFIIG GIIFLIVEYY YKEQAWHVKD VEKVSWTQAW WVGFAQIFSL 150
    IPGTSRAGAT IIGGLLAGLD RKTSAEFSFL LAIPVMAVVS GYDLLKHYQD 200
    FADANWGAFL IGFIVAFIVA YATIKLFLVF LQRFTFVAFG IYRIIFGIFL 250
    LMIL 254
    Length:254
    Mass (Da):28,689
    Last modified:August 21, 2007 - v1
    Checksum:i9074C90482989C76
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009179 Genomic DNA. Translation: BAF72387.1.
    RefSeqiWP_011981120.1. NC_009663.1.
    YP_001358744.1. NC_009663.1.

    Genome annotation databases

    EnsemblBacteriaiBAF72387; BAF72387; SUN_1436.
    GeneIDi5362912.
    KEGGisun:SUN_1436.
    PATRICi23775877. VBISulSp49917_1462.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009179 Genomic DNA. Translation: BAF72387.1 .
    RefSeqi WP_011981120.1. NC_009663.1.
    YP_001358744.1. NC_009663.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 387093.SUN_1436.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAF72387 ; BAF72387 ; SUN_1436 .
    GeneIDi 5362912.
    KEGGi sun:SUN_1436.
    PATRICi 23775877. VBISulSp49917_1462.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218356.
    KOi K06153.
    OMAi FNDAHAK.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci SSP387093:GH25-1456-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Deep-sea vent epsilon-proteobacterial genomes provide insights into emergence of pathogens."
      Nakagawa S., Takaki Y., Shimamura S., Reysenbach A.-L., Takai K., Horikoshi K.
      Proc. Natl. Acad. Sci. U.S.A. 104:12146-12150(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NBC37-1.

    Entry informationi

    Entry nameiUPPP_SULNB
    AccessioniPrimary (citable) accession number: A6QA78
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3