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A6Q9P9

- GSA_SULNB

UniProt

A6Q9P9 - GSA_SULNB

Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Sulfurovum sp. (strain NBC37-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: InterPro

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Porphyrin biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciSSP387093:GH25-1269-MONOMER.
    UniPathwayiUPA00251; UER00317.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
    Short name:
    GSAUniRule annotation
    Alternative name(s):
    Glutamate-1-semialdehyde aminotransferaseUniRule annotation
    Short name:
    GSA-ATUniRule annotation
    Gene namesi
    Name:hemLUniRule annotation
    Ordered Locus Names:SUN_1254
    OrganismiSulfurovum sp. (strain NBC37-1)
    Taxonomic identifieri387093 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaSulfurovum
    ProteomesiUP000006378: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 430430Glutamate-1-semialdehyde 2,1-aminomutasePRO_1000060003Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei267 – 2671N6-(pyridoxal phosphate)lysineUniRule annotation

    Proteomic databases

    PRIDEiA6Q9P9.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi387093.SUN_1254.

    Structurei

    3D structure databases

    ProteinModelPortaliA6Q9P9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0001.
    HOGENOMiHOG000020210.
    KOiK01845.
    OMAiRAIKPYP.
    OrthoDBiEOG6QVRHN.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPiMF_00375. HemL_aminotrans_3.
    InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00713. hemL. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6Q9P9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAYDKSIAAF EEAYKVIPGG VDSPVRAFSG VEGTPPFIER GEGAYLFDID    50
    GNRYIDYVQS WGPLIFGHTD ADIEASVIDS VKKGLSFGAP TTVETELAEE 100
    IVLMFESIDK VRFVSSGTEA VMSAIRLARG ATGRDNILKF TGCYHGHSDS 150
    LLVQAGSGLA TFGTPSSPGV PADLTKHTLL GTYNDIESVE KCFADSPEGI 200
    ACVIIEPIAG NMGLVPADET FLQQLRALCD AHGTLLIFDE VMSGFRASLK 250
    GAQGITTVKP DMVTLGKVIG AGMPVGAFGA GAETMAQLSP EGPVYQAGTL 300
    SGNPVAMAAG LTSLRKLKAN PAIYVELGNK AKKLVEGLKR AADSVNVPMV 350
    TDVRGSMFGF FFSDKPVKNF ADAMENDQKL FAKFHKGMLD RGIYLACSSF 400
    ETGFISTAIT DEMIDETVKA AYETLKEIKG 430
    Length:430
    Mass (Da):45,655
    Last modified:August 21, 2007 - v1
    Checksum:i8ED3F48106CAEBC3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009179 Genomic DNA. Translation: BAF72208.1.
    RefSeqiWP_011980941.1. NC_009663.1.
    YP_001358565.1. NC_009663.1.

    Genome annotation databases

    EnsemblBacteriaiBAF72208; BAF72208; SUN_1254.
    GeneIDi5363366.
    KEGGisun:SUN_1254.
    PATRICi23775485. VBISulSp49917_1271.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009179 Genomic DNA. Translation: BAF72208.1 .
    RefSeqi WP_011980941.1. NC_009663.1.
    YP_001358565.1. NC_009663.1.

    3D structure databases

    ProteinModelPortali A6Q9P9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 387093.SUN_1254.

    Proteomic databases

    PRIDEi A6Q9P9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAF72208 ; BAF72208 ; SUN_1254 .
    GeneIDi 5363366.
    KEGGi sun:SUN_1254.
    PATRICi 23775485. VBISulSp49917_1271.

    Phylogenomic databases

    eggNOGi COG0001.
    HOGENOMi HOG000020210.
    KOi K01845.
    OMAi RAIKPYP.
    OrthoDBi EOG6QVRHN.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00317 .
    BioCyci SSP387093:GH25-1269-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPi MF_00375. HemL_aminotrans_3.
    InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00713. hemL. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Deep-sea vent epsilon-proteobacterial genomes provide insights into emergence of pathogens."
      Nakagawa S., Takaki Y., Shimamura S., Reysenbach A.-L., Takai K., Horikoshi K.
      Proc. Natl. Acad. Sci. U.S.A. 104:12146-12150(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NBC37-1.

    Entry informationi

    Entry nameiGSA_SULNB
    AccessioniPrimary (citable) accession number: A6Q9P9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3