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A6Q9D4

- SYE2_SULNB

UniProt

A6Q9D4 - SYE2_SULNB

Protein

Glutamate--tRNA ligase 2

Gene

gltX2

Organism
Sulfurovum sp. (strain NBC37-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).By similarity

    Catalytic activityi

    ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutamate-tRNA ligase activity Source: UniProtKB-EC
    3. tRNA binding Source: InterPro

    GO - Biological processi

    1. glutamyl-tRNA aminoacylation Source: InterPro

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSSP387093:GH25-1153-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate--tRNA ligase 2 (EC:6.1.1.17)
    Alternative name(s):
    Glutamyl-tRNA synthetase 2
    Short name:
    GluRS 2
    Gene namesi
    Name:gltX2
    Ordered Locus Names:SUN_1138
    OrganismiSulfurovum sp. (strain NBC37-1)
    Taxonomic identifieri387093 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaSulfurovum
    ProteomesiUP000006378: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 428428Glutamate--tRNA ligase 2PRO_0000367778Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi387093.SUN_1138.

    Structurei

    3D structure databases

    ProteinModelPortaliA6Q9D4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi6 – 1611"HIGH" regionAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0008.
    HOGENOMiHOG000252720.
    KOiK01885.
    OMAiIFNYICS.
    OrthoDBiEOG6DRPF7.

    Family and domain databases

    Gene3Di1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
    IPR004527. Glu-tRNA-ligase_bac/mito.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR10119. PTHR10119. 1 hit.
    PfamiPF00749. tRNA-synt_1c. 1 hit.
    [Graphical view]
    PRINTSiPR00987. TRNASYNTHGLU.
    SUPFAMiSSF48163. SSF48163. 1 hit.
    TIGRFAMsiTIGR00464. gltX_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A6Q9D4-1 [UniParc]FASTAAdd to Basket

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    MLRFAPSPTG DMRTEQLRIA IFNYIVAKQK EVNFIVRIED TDKERNITGK    50
    DTEILQILEK FAITHDSVFH QSEHLNIHQT LAIRLLEEGK AFVCTCTPEA 100
    PESDKTPSRY NGKCFNVDKE ELKRLKEEKI PFVIRLKKPE HDMIIHDLYK 150
    GETVTSADEV DSFVILRADA TPTENFASAC DDMLSGIDFI IRSEEHLDET 200
    AKQEYVKKQL GYEEETTYAH LPVILNEEGQ KMDEKDDAFT VKWLFEEGYI 250
    PDAIANYLIS LGNTTPTDIF TLPEAIEWFN ITKLSGSPVK FNIEELRLLN 300
    RKHLEKMDDK RLSSLFGFAD ADIGKLAKLY INEAATINEL DARIKAIFSP 350
    KDFDGKWGEQ MRMLEKIIAE APMFATFEAF ESHLMKESGL SGEYFSKPLR 400
    VLLTGAEQGP ELSDIYPYIK SYLLEVAS 428
    Length:428
    Mass (Da):48,962
    Last modified:August 21, 2007 - v1
    Checksum:i57A3F687C6A48033
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009179 Genomic DNA. Translation: BAF72093.1.
    RefSeqiWP_011980826.1. NC_009663.1.
    YP_001358450.1. NC_009663.1.

    Genome annotation databases

    EnsemblBacteriaiBAF72093; BAF72093; SUN_1138.
    GeneIDi5362086.
    KEGGisun:SUN_1138.
    PATRICi23775243. VBISulSp49917_1150.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009179 Genomic DNA. Translation: BAF72093.1 .
    RefSeqi WP_011980826.1. NC_009663.1.
    YP_001358450.1. NC_009663.1.

    3D structure databases

    ProteinModelPortali A6Q9D4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 387093.SUN_1138.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAF72093 ; BAF72093 ; SUN_1138 .
    GeneIDi 5362086.
    KEGGi sun:SUN_1138.
    PATRICi 23775243. VBISulSp49917_1150.

    Phylogenomic databases

    eggNOGi COG0008.
    HOGENOMi HOG000252720.
    KOi K01885.
    OMAi IFNYICS.
    OrthoDBi EOG6DRPF7.

    Enzyme and pathway databases

    BioCyci SSP387093:GH25-1153-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
    IPR004527. Glu-tRNA-ligase_bac/mito.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR10119. PTHR10119. 1 hit.
    Pfami PF00749. tRNA-synt_1c. 1 hit.
    [Graphical view ]
    PRINTSi PR00987. TRNASYNTHGLU.
    SUPFAMi SSF48163. SSF48163. 1 hit.
    TIGRFAMsi TIGR00464. gltX_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Deep-sea vent epsilon-proteobacterial genomes provide insights into emergence of pathogens."
      Nakagawa S., Takaki Y., Shimamura S., Reysenbach A.-L., Takai K., Horikoshi K.
      Proc. Natl. Acad. Sci. U.S.A. 104:12146-12150(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NBC37-1.

    Entry informationi

    Entry nameiSYE2_SULNB
    AccessioniPrimary (citable) accession number: A6Q9D4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3