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A6Q908 (AROB_SULNB) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:SUN_1010
OrganismSulfurovum sp. (strain NBC37-1) [Complete proteome] [HAMAP]
Taxonomic identifier387093 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Sulfurovum

Protein attributes

Sequence length350 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP MF_00110

NAD By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm By similarity HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3503503-dehydroquinate synthase HAMAP MF_00110
PRO_1000094644

Sequences

Sequence LengthMass (Da)Tools
A6Q908 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 4B42C059F9078D48

FASTA35038,807
        10         20         30         40         50         60 
MIVPIELAHT KNITYDITID ALPQLTFDTK VAVVTNPTVA GYHLQTLLAH IKAPQLEVIT 

        70         80         90        100        110        120 
VPDGEEYKTL ETVETILNEL FEHKFDRKSL LIAFGGGVIG DMTGFTASLY QRGIDFIQIP 

       130        140        150        160        170        180 
TTLLSQVDAS VGGKTGVNNR YGKNLIGAFY QPKAVYIDPA FLKTLPSREF SAGVAEIIKM 

       190        200        210        220        230        240 
AVMFDKDYFE FLVTADLSDE EVLKETIRRS VELKAWVVNQ DEKEAGIRAV LNYGHTFGHV 

       250        260        270        280        290        300 
VENETGYTTY LHGEAVAIGM VMANALAVEL GLLGETEADR IKALLEKASL PTHYTIKDVD 

       310        320        330        340        350 
DFYEHFFLDK KSANNSIKFI LPEGIGGHKI VSDIDESVVK NVLKKFEEEV

« Hide

References

[1]"Deep-sea vent epsilon-proteobacterial genomes provide insights into emergence of pathogens."
Nakagawa S., Takaki Y., Shimamura S., Reysenbach A.-L., Takai K., Horikoshi K.
Proc. Natl. Acad. Sci. U.S.A. 104:12146-12150(2007) [PubMed: 17615243] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NBC37-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP009179 Genomic DNA. Translation: BAF71967.1.
RefSeqYP_001358324.1. NC_009663.1.

3D structure databases

ProteinModelPortalA6Q908.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6Q908.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5362451.
GenomeReviewsGene locus SUN_1010 in contig AP009179_GR.
KEGGsun:SUN_1010.
NMPDRfig|387093.4.peg.968.
PATRIC23774981. VBISulSp49917_1019.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0337.
HOGENOMHBG632303.
OMAGTFTQPD.
ProtClustDBPRK00002.

Enzyme and pathway databases

BioCycSSP387093:SUN_1010-MONOMER.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_SULNB
AccessionPrimary (citable) accession number: A6Q908
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: August 21, 2007
Last modified: December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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