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A6Q6M8

- DDL_SULNB

UniProt

A6Q6M8 - DDL_SULNB

Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Sulfurovum sp. (strain NBC37-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Cell wall formation.UniRule annotation

    Catalytic activityi

    ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotation

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi284 – 2841Magnesium or manganese 1UniRule annotation
    Metal bindingi296 – 2961Magnesium or manganese 1UniRule annotation
    Metal bindingi296 – 2961Magnesium or manganese 2UniRule annotation
    Metal bindingi298 – 2981Magnesium or manganese 2UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi161 – 21252ATPUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. D-alanine-D-alanine ligase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP
    4. manganese ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
    2. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSSP387093:GH25-186-MONOMER.
    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
    Alternative name(s):
    D-Ala-D-Ala ligaseUniRule annotation
    D-alanylalanine synthetaseUniRule annotation
    Gene namesi
    Name:ddlUniRule annotation
    Ordered Locus Names:SUN_0177
    OrganismiSulfurovum sp. (strain NBC37-1)
    Taxonomic identifieri387093 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaSulfurovum
    ProteomesiUP000006378: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 346346D-alanine--D-alanine ligasePRO_1000074801Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi387093.SUN_0177.

    Structurei

    3D structure databases

    ProteinModelPortaliA6Q6M8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini134 – 340207ATP-graspUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the D-alanine--D-alanine ligase family.UniRule annotation
    Contains 1 ATP-grasp domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1181.
    HOGENOMiHOG000102494.
    KOiK01921.
    OMAiHNGLLKN.
    OrthoDBiEOG6ND0KB.

    Family and domain databases

    Gene3Di3.30.1490.20. 1 hit.
    3.30.470.20. 2 hits.
    3.40.50.20. 1 hit.
    HAMAPiMF_00047. Dala_Dala_lig.
    InterProiIPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR000291. D-Ala_lig_Van_CS.
    IPR005905. D_ala_D_ala.
    IPR011095. Dala_Dala_lig_C.
    IPR011127. Dala_Dala_lig_N.
    IPR016185. PreATP-grasp_dom.
    [Graphical view]
    PANTHERiPTHR23132. PTHR23132. 1 hit.
    PfamiPF07478. Dala_Dala_lig_C. 1 hit.
    PF01820. Dala_Dala_lig_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF52440. SSF52440. 1 hit.
    TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
    PROSITEiPS50975. ATP_GRASP. 1 hit.
    PS00843. DALA_DALA_LIGASE_1. 1 hit.
    PS00844. DALA_DALA_LIGASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6Q6M8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNIAILFGGS SFEHEISIVS AITMKKVLKK STLTYIFVSA DRKFYLIDTE    50
    KINSKLFSSG EYKKGKQLVL KNDGFFTKGM FGSKQVAFDV LLNLIHGRDG 100
    EDGKVASMME FFNIPYISPR LEASAMSYNK LYTKFLAESL GVKTVPYEHL 150
    SKNGDRKISM EYPVIIKPVR LGSSIGVSIV KSEAELDYAL DVAFEFDNDV 200
    IVEPFIDGVK EFNQAGCHTG DWELSIVEEP QKEEFLDFEK KYMDFSRDSQ 250
    VLSADISEEL KNNIQVTFKK IYDPLFMGSI IRCDFFVVND EILLNEINPI 300
    PGSMANYLFP DFEGMVWRLS KALPKEKNIS IDYTYIHSIQ SAKGKA 346
    Length:346
    Mass (Da):39,235
    Last modified:August 21, 2007 - v1
    Checksum:iF367FCAD762D3950
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009179 Genomic DNA. Translation: BAF71137.1.
    RefSeqiWP_011979870.1. NC_009663.1.
    YP_001357494.1. NC_009663.1.

    Genome annotation databases

    EnsemblBacteriaiBAF71137; BAF71137; SUN_0177.
    GeneIDi5362644.
    KEGGisun:SUN_0177.
    PATRICi23773289. VBISulSp49917_0178.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009179 Genomic DNA. Translation: BAF71137.1 .
    RefSeqi WP_011979870.1. NC_009663.1.
    YP_001357494.1. NC_009663.1.

    3D structure databases

    ProteinModelPortali A6Q6M8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 387093.SUN_0177.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAF71137 ; BAF71137 ; SUN_0177 .
    GeneIDi 5362644.
    KEGGi sun:SUN_0177.
    PATRICi 23773289. VBISulSp49917_0178.

    Phylogenomic databases

    eggNOGi COG1181.
    HOGENOMi HOG000102494.
    KOi K01921.
    OMAi HNGLLKN.
    OrthoDBi EOG6ND0KB.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .
    BioCyci SSP387093:GH25-186-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1490.20. 1 hit.
    3.30.470.20. 2 hits.
    3.40.50.20. 1 hit.
    HAMAPi MF_00047. Dala_Dala_lig.
    InterProi IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR000291. D-Ala_lig_Van_CS.
    IPR005905. D_ala_D_ala.
    IPR011095. Dala_Dala_lig_C.
    IPR011127. Dala_Dala_lig_N.
    IPR016185. PreATP-grasp_dom.
    [Graphical view ]
    PANTHERi PTHR23132. PTHR23132. 1 hit.
    Pfami PF07478. Dala_Dala_lig_C. 1 hit.
    PF01820. Dala_Dala_lig_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52440. SSF52440. 1 hit.
    TIGRFAMsi TIGR01205. D_ala_D_alaTIGR. 1 hit.
    PROSITEi PS50975. ATP_GRASP. 1 hit.
    PS00843. DALA_DALA_LIGASE_1. 1 hit.
    PS00844. DALA_DALA_LIGASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Deep-sea vent epsilon-proteobacterial genomes provide insights into emergence of pathogens."
      Nakagawa S., Takaki Y., Shimamura S., Reysenbach A.-L., Takai K., Horikoshi K.
      Proc. Natl. Acad. Sci. U.S.A. 104:12146-12150(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NBC37-1.

    Entry informationi

    Entry nameiDDL_SULNB
    AccessioniPrimary (citable) accession number: A6Q6M8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3