A6Q675 (CLPP_SULNB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATP-dependent Clp protease proteolytic subunit
EC=3.4.21.92

Alternative name(s):
Endopeptidase Clp

Gene names

Name:	clpP
Ordered Locus Names:	SUN_0012

Organism

Sulfurovum sp. (strain NBC37-1) [Complete proteome] [HAMAP]

Taxonomic identifier

387093 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Sulfurovum

Protein attributes

Sequence length	195 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins By similarity. HAMAP MF_00444
Catalytic activity	Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs). HAMAP MF_00444
Subcellular location	Cytoplasm By similarity HAMAP MF_00444.
Sequence similarities	Belongs to the peptidase S14 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase Protease Serine protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 195	195	ATP-dependent Clp protease proteolytic subunit HAMAP MF_00444		PRO_1000026139
Sites
	Active site	98	1	By similarity
	Active site	123	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6Q675 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: A991712C8BF142E1	FASTA	195	21,657
	10 20 30 40 50 60 MSYIPYVVEQ TGRGERSYDI YSRLLKDRII MLSGEVNDQV ASSIVAQLLF LEAQDPDKDI 70 80 90 100 110 120 YFYINSPGGV ITSGLSMFDT MNYIKPDIVT ICIGQAASMG AFLLASGTKG KRYALPHARI 130 140 150 160 170 180 MIHQPSGGAQ GQSTDIQIQA QEIQRLKDTL NEIMAEKTGK TAKRIEKDTE RDNFMSAKEA 190 VEYGLIDKVL TKSFT

References

[1]

"Deep-sea vent epsilon-proteobacterial genomes provide insights into emergence of pathogens." Nakagawa S., Takaki Y., Shimamura S., Reysenbach A.-L., Takai K., Horikoshi K. Proc. Natl. Acad. Sci. U.S.A. 104:12146-12150(2007) [PubMed: 17615243] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NBC37-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009179 Genomic DNA. Translation: BAF70973.1.
RefSeq	YP_001357330.1. NC_009663.1.
3D structure databases
ProteinModelPortal	A6Q675.
SMR	A6Q675. Positions 4-191.
ModBase	Search...
Protein-protein interaction databases
STRING	A6Q675.
Protein family/group databases
MEROPS	S14.001.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5362878.
GenomeReviews	Gene locus SUN_0012 in contig AP009179_GR.
KEGG	sun:SUN_0012.
NMPDR	fig|387093.4.peg.12.
PATRIC	23772943. VBISulSp49917_0012.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0740.
HOGENOM	HBG558421.
OMA	CTICIGL.
ProtClustDB	PRK00277.
Enzyme and pathway databases
BioCyc	SSP387093:SUN_0012-MONOMER.
Family and domain databases
HAMAP	MF_00444. ClpP. [Tree]
InterPro	IPR023562. Pept_S14/S49. IPR001907. Pept_S14_ClpP. IPR018215. Pept_S14_ClpP_AS. [Graphical view]
KO	K01358.
PANTHER	PTHR10381. Pept_S14_ClpP. 1 hit.
Pfam	PF00574. CLP_protease. 1 hit. [Graphical view]
PRINTS	PR00127. CLPPROTEASEP.
TIGRFAMs	TIGR00493. ClpP. 1 hit.
PROSITE	PS00382. CLP_PROTEASE_HIS. 1 hit. PS00381. CLP_PROTEASE_SER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CLPP_SULNB

Accession

Primary (citable) accession number: A6Q675

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 21, 2007
Last modified:	December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program